Interplay between miRNAs and host genes and their role in cancer

MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-transcriptionally regulate gene expression. They play essential roles in nearly all biological processes including cell development and differentiation, DNA damage repair, cell death as well as intercellular communication....

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Published inBriefings in functional genomics Vol. 18; no. 4; pp. 255 - 266
Main Authors Liu, Baohong, Shyr, Yu, Cai, Jianping, Liu, Qi
Format Journal Article
LanguageEnglish
Published England Oxford University Press 22.07.2019
Subjects
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
MicroRNAs - metabolism
Neoplasms - genetics
Oncogenes
Review Paper
miRNA
cancer
interplay
host genes
intragenic miRNA biogenesis
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Abstract MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-transcriptionally regulate gene expression. They play essential roles in nearly all biological processes including cell development and differentiation, DNA damage repair, cell death as well as intercellular communication. They are highly involved in cancer, acting as tumor suppressors and/or promoters to modulate cell proliferation, epithelial-mesenchymal transition and tumor invasion and metastasis. Recent studies have shown that more than half of miRNAs are located within protein-coding or non-coding genes. Intragenic miRNAs and their host genes either share the promoter or have independent transcription. Meanwhile, miRNAs work as partners or antagonists of their host genes by fine-tuning their target genes functionally associated with host genes. This review outlined the complicated relationship between intragenic miRNAs and host genes. Focusing on miRNAs known as oncogenes or tumor suppressors in specific cancer types, it studied co-expression relationships between these miRNAs and host genes in the cancer types using TCGA data sets, which validated previous findings and revealed common, tumor-specific and even subtype-specific patterns. These observations will help understand the function of intragenic miRNAs and further develop miRNA therapeutics in cancer.
AbstractList MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-transcriptionally regulate gene expression. They play essential roles in nearly all biological processes including cell development and differentiation, DNA damage repair, cell death as well as intercellular communication. They are highly involved in cancer, acting as tumor suppressors and/or promoters to modulate cell proliferation, epithelial-mesenchymal transition and tumor invasion and metastasis. Recent studies have shown that more than half of miRNAs are located within protein-coding or non-coding genes. Intragenic miRNAs and their host genes either share the promoter or have independent transcription. Meanwhile, miRNAs work as partners or antagonists of their host genes by fine-tuning their target genes functionally associated with host genes. This review outlined the complicated relationship between intragenic miRNAs and host genes. Focusing on miRNAs known as oncogenes or tumor suppressors in specific cancer types, it studied co-expression relationships between these miRNAs and host genes in the cancer types using TCGA data sets, which validated previous findings and revealed common, tumor-specific and even subtype-specific patterns. These observations will help understand the function of intragenic miRNAs and further develop miRNA therapeutics in cancer.
MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-transcriptionally regulate gene expression. They play essential roles in nearly all biological processes including cell development and differentiation, DNA damage repair, cell death as well as intercellular communication. They are highly involved in cancer, acting as tumor suppressors and/or promoters to modulate cell proliferation, epithelial-mesenchymal transition and tumor invasion and metastasis. Recent studies have shown that more than half of miRNAs are located within protein-coding or non-coding genes. Intragenic miRNAs and their host genes either share the promoter or have independent transcription. Meanwhile, miRNAs work as partners or antagonists of their host genes by fine-tuning their target genes functionally associated with host genes. This review outlined the complicated relationship between intragenic miRNAs and host genes. Focusing on miRNAs known as oncogenes or tumor suppressors in specific cancer types, it studied co-expression relationships between these miRNAs and host genes in the cancer types using TCGA data sets, which validated previous findings and revealed common, tumor-specific and even subtype-specific patterns. These observations will help understand the function of intragenic miRNAs and further develop miRNA therapeutics in cancer.MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-transcriptionally regulate gene expression. They play essential roles in nearly all biological processes including cell development and differentiation, DNA damage repair, cell death as well as intercellular communication. They are highly involved in cancer, acting as tumor suppressors and/or promoters to modulate cell proliferation, epithelial-mesenchymal transition and tumor invasion and metastasis. Recent studies have shown that more than half of miRNAs are located within protein-coding or non-coding genes. Intragenic miRNAs and their host genes either share the promoter or have independent transcription. Meanwhile, miRNAs work as partners or antagonists of their host genes by fine-tuning their target genes functionally associated with host genes. This review outlined the complicated relationship between intragenic miRNAs and host genes. Focusing on miRNAs known as oncogenes or tumor suppressors in specific cancer types, it studied co-expression relationships between these miRNAs and host genes in the cancer types using TCGA data sets, which validated previous findings and revealed common, tumor-specific and even subtype-specific patterns. These observations will help understand the function of intragenic miRNAs and further develop miRNA therapeutics in cancer.
Author Shyr, Yu
Liu, Baohong
Cai, Jianping
Liu, Qi
AuthorAffiliation 3 Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA
4 Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China
1 State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, China
2 Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
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  surname: Liu
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  organization: Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA, Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA
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Cites_doi 10.1089/dna.2006.0558
10.3892/or.2017.5566
10.7150/jca.16723
10.1016/j.gendis.2014.06.004
10.1093/gbe/evs002
10.1038/s41598-017-08502-z
10.3892/ol.2017.6163
10.1158/1078-0432.CCR-12-2952
10.3892/etm.2016.3783
10.1016/j.molcel.2010.05.027
10.1073/pnas.1502068112
10.3390/ijms19010065
10.1038/onc.2011.380
10.3892/ijo.2012.1724
10.1016/j.mce.2010.11.027
10.1093/database/bau099
10.1158/0008-5472.CAN-08-1768
10.1002/iub.1079
10.1093/nar/gks308
10.3324/haematol.2013.099515
10.1186/s12935-018-0545-8
10.1126/science.1162253
10.1016/S0092-8674(04)00045-5
10.4103/0019-509X.186576
10.1016/j.molonc.2013.10.001
10.1038/s41598-017-06137-8
10.1016/j.ydbio.2006.08.028
10.1016/j.biopha.2018.04.101
10.1007/978-1-62703-083-0_5
10.3892/or.2015.3952
10.1016/j.cell.2009.01.002
10.1038/onc.2013.291
10.1038/ncb2024
10.1093/abbs/gmx132
10.1261/rna.7240905
10.1038/sj.onc.1209913
10.7150/ijbs.20836
10.3892/ijo.2015.3114
10.4161/cc.8.16.9305
10.1016/j.bbrc.2008.12.098
10.1016/j.molcel.2013.05.007
10.1038/sj.emboj.7601512
10.1016/j.juro.2009.09.086
10.1158/0008-5472.CAN-07-5194
10.1007/s13238-014-0093-5
10.1038/nm.2940
10.1093/nar/gkx318
10.3892/ijo.2016.3503
10.1016/j.biopha.2017.08.088
10.1093/carcin/bgx134
10.18632/oncotarget.19521
10.1186/1471-2164-11-533
10.1016/j.ygeno.2010.10.005
10.1158/0008-5472.CAN-11-0364
10.1002/cncr.25860
10.2741/2865
10.1093/nar/gkq1027
10.1186/s13148-017-0413-8
10.1073/pnas.0808830105
10.1186/s12885-016-2109-4
10.1093/nar/gkt1181
10.1038/srep34034
10.1073/pnas.242606799
10.1038/boneres.2015.33
10.1155/2015/326042
10.1158/1078-0432.CCR-13-2642
10.1101/gad.1974211
10.18632/oncotarget.7071
10.1101/gad.177774.111
10.4161/cbt.10.12.14252
10.3892/or.2015.4240
10.1186/1471-2490-12-14
10.1074/jbc.M611393200
10.1155/2016/9513037
10.18632/oncotarget.14184
10.1038/cddis.2017.281
10.1038/onc.2008.10
10.1073/pnas.0902636106
10.3892/ijo.2014.2349
10.4331/wjbc.v8.i1.45
10.1038/cr.2016.32
10.1016/j.canlet.2016.01.051
10.1093/hmg/ddx138
10.3892/or.2013.2482
10.1093/nar/gki200
10.3892/or.2016.4749
10.1002/ijc.25143
10.3390/jcm4081651
10.1186/s12885-016-2231-3
10.1053/j.gastro.2007.05.022
10.1038/ncomms6700
10.1042/BJ20101585
10.1007/s13402-015-0247-3
10.1002/ijc.28091
10.1172/JCI64946
10.1038/nature13992
10.18632/oncotarget.2294
10.1210/jc.2011-0345
10.18632/oncotarget.16310
10.1186/s12943-017-0688-6
10.1038/nature11890
10.1101/gad.1706508
10.4049/jimmunol.179.8.5082
10.1093/nar/gkt1413
10.1186/s12935-017-0387-9
10.1158/0008-5472.CAN-10-0141
10.1093/nar/gkr1312
10.1158/1541-7786.MCR-11-0272
10.1007/s10529-010-0415-5
10.3892/ol.2017.5673
10.1371/journal.pone.0062589
10.1371/journal.pone.0031022
10.1371/journal.pone.0005279
10.1007/s13277-015-4645-y
10.1158/1535-7163.MCT-16-0096
10.1186/1471-2164-11-224
10.1038/nrd3179
10.2174/138920210793175895
10.18632/oncotarget.18060
10.1186/s13027-015-0037-6
10.1158/0008-5472.CAN-08-0325
10.3892/ijo.2017.3948
10.1158/0008-5472.CAN-13-3319
10.1007/s13277-015-3317-2
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Issue 4
Keywords miRNA
cancer
interplay
host genes
intragenic miRNA biogenesis
Language English
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The Author(s) 2019. Published by Oxford University Press.
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References Bartel (2019091011553984800_ref5) 2004; 116
Reis (2019091011553984800_ref65) 2012; 12
Yan (2019091011553984800_ref49) 2017; 37
Ohtsuka (2019091011553984800_ref3) 2015; 4
Nguyen (2019091011553984800_ref126) 2017; 19
Bischoff (2019091011553984800_ref86) 2014; 74
Kim (2019091011553984800_ref27) 2007; 26
Zhou (2019091011553984800_ref87) 2015; 34
Riquelme (2019091011553984800_ref75) 2016; 39
Grady (2019091011553984800_ref107) 2008; 27
Liu (2019091011553984800_ref84) 2018; 18
Li (2019091011553984800_ref109) 2018; 103
Jing (2019091011553984800_ref9) 2015; 2015
Palma Flores (2019091011553984800_ref48) 2017; 50
Zhang (2019091011553984800_ref120) 2017; 17
Agranat-Tamir (2019091011553984800_ref36) 2014; 42
Kim (2019091011553984800_ref41) 2008; 105
Huo (2019091011553984800_ref10) 2017; 8
Guo (2019091011553984800_ref124) 2015; 34
Campos-Viguri (2019091011553984800_ref66) 2015; 10
Daniunaite (2019091011553984800_ref127) 2017; 26
Cui (2019091011553984800_ref128) 2015; 112
Frixa (2019091011553984800_ref45) 2018; 39
Hamada (2019091011553984800_ref78) 2012; 10
Goto (2019091011553984800_ref70) 2014; 5
Letelier (2019091011553984800_ref53) 2014; 7
O'Connell (2019091011553984800_ref91) 2009; 106
Ren (2019091011553984800_ref97) 2017; 16
Leone (2019091011553984800_ref52) 2011; 96
Kozomara (2019091011553984800_ref21) 2014; 42
Ye (2019091011553984800_ref74) 2016; 6
Wu (2019091011553984800_ref106) 2011; 117
Nozawa (2019091011553984800_ref2) 2012; 4
Hinske (2019091011553984800_ref15) 2010; 11
Meng (2019091011553984800_ref60) 2007; 133
Budd (2019091011553984800_ref110) 2012
Kozaki (2019091011553984800_ref82) 2008; 68
Patel (2019091011553984800_ref123) 2011; 434
Zhang (2019091011553984800_ref8) 2017; 7
Pan (2019091011553984800_ref61) 2010; 10
Petrocca (2019091011553984800_ref121) 2008; 68
Li (2019091011553984800_ref132) 2016; 15
Imamura (2019091011553984800_ref77) 2017; 7
Gao (2019091011553984800_ref12) 2012; 64
Ma (2019091011553984800_ref55) 2010; 12
Meng (2019091011553984800_ref56) 2017; 8
Mets (2019091011553984800_ref79) 2014; 99
Li (2019091011553984800_ref69) 2017; 8
Liu (2019091011553984800_ref76) 2017; 45
Bartel (2019091011553984800_ref1) 2009; 136
Zhang (2019091011553984800_ref113) 2016; 6
He (2019091011553984800_ref11) 2012; 40
Scarola (2019091011553984800_ref101) 2010; 70
Schmitt (2019091011553984800_ref44) 2014; 3
Papagiannakopoulos (2019091011553984800_ref81) 2012; 31
Baskerville (2019091011553984800_ref26) 2005; 11
Kasar (2019091011553984800_ref129) 2014; 33
Chow (2019091011553984800_ref59) 2010; 183
Cao (2019091011553984800_ref102) 2013; 30
Tan (2019091011553984800_ref68) 2015; 3
Macfarlane (2019091011553984800_ref57) 2010; 11
Zhang (2019091011553984800_ref47) 2007; 302
Ozsolak (2019091011553984800_ref35) 2008; 22
Majid (2019091011553984800_ref73) 2013; 19
Leivonen (2019091011553984800_ref118) 2014; 8
Hui (2019091011553984800_ref95) 2016; 9
Due (2019091011553984800_ref89) 2016; 2016
Griffiths-Jones (2019091011553984800_ref24) 2006; 342
Hu (2019091011553984800_ref115) 2010; 38
Price (2019091011553984800_ref133) 2014; 1
Hashimoto (2019091011553984800_ref99) 2013; 8
Dill (2019091011553984800_ref43) 2012; 26
Yang (2019091011553984800_ref88) 2017; 95
Gambari (2019091011553984800_ref125) 2016; 49
Kristensen (2019091011553984800_ref122) 2014; 20
Perron (2019091011553984800_ref4) 2008; 13
Zhu (2019091011553984800_ref62) 2007; 282
Calin (2019091011553984800_ref6) 2002; 99
Dong-Xu (2019091011553984800_ref94) 2015; 52
Liu (2019091011553984800_ref98) 2016; 35
Kos (2019091011553984800_ref42) 2012; 7
Taylor (2019091011553984800_ref93) 2013; 123
Sandoval-Borquez (2019091011553984800_ref103) 2017; 9
Jin (2019091011553984800_ref105) 2015; 47
Althoff (2019091011553984800_ref83) 2013; 133
Sun (2019091011553984800_ref100) 2016; 7
Tsuruta (2019091011553984800_ref67) 2011; 71
Cui (2019091011553984800_ref117) 2016; 374
Oliveto (2019091011553984800_ref7) 2017; 8
Li (2019091011553984800_ref32) 2007; 26
Sundaram (2019091011553984800_ref37) 2013; 495
Chen (2019091011553984800_ref54) 2012; 18
Song (2019091011553984800_ref85) 2014; 5
Schanen (2019091011553984800_ref33) 2011; 97
Corcoran (2019091011553984800_ref28) 2009; 4
Dohi (2019091011553984800_ref29) 2013; 42
Kim (2019091011553984800_ref34) 2017; 8
Hu (2019091011553984800_ref96) 2017; 13
Yi (2019091011553984800_ref111) 2016; 12
Georgakilas (2019091011553984800_ref16) 2014; 5
Griffiths-Jones (2019091011553984800_ref23) 2010
Li (2019091011553984800_ref14) 2016; 26
Peralta-Zaragoza (2019091011553984800_ref63) 2016; 16
Zhang (2019091011553984800_ref71) 2017; 14
Hinske (2019091011553984800_ref51) 2013; 936
Saito (2019091011553984800_ref130) 2009; 379
Melamed (2019091011553984800_ref39) 2013; 50
Ma (2019091011553984800_ref13) 2011; 333
Griffiths-Jones (2019091011553984800_ref25) 2008; 36
Lutter (2019091011553984800_ref20) 2010; 11
Karatas (2019091011553984800_ref72) 2017; 8
Sun (2019091011553984800_ref31) 2017; 13
Toyota (2019091011553984800_ref40) 2008; 68
Kent (2019091011553984800_ref58) 2006; 25
Png (2019091011553984800_ref119) 2011; 25
Yue (2019091011553984800_ref92) 2014; 515
Bi (2019091011553984800_ref46) 2018; 15
Zhang (2019091011553984800_ref64) 2016; 16
Tili (2019091011553984800_ref90) 2007; 179
Kozomara (2019091011553984800_ref22) 2011; 39
Cheng (2019091011553984800_ref50) 2005; 33
Garzon (2019091011553984800_ref131) 2010; 9
Liu (2019091011553984800_ref104) 2015; 36
Seila (2019091011553984800_ref17) 2008; 322
Seila (2019091011553984800_ref18) 2009; 8
Zhao (2019091011553984800_ref112) 2016; 37
Barron (2019091011553984800_ref30) 2011; 33
Ribas (2019091011553984800_ref38) 2012; 40
Zhu (2019091011553984800_ref108) 2017; 8
Nakano (2019091011553984800_ref114) 2010; 127
Hinske (2019091011553984800_ref19) 2014; 2014
Zhao (2019091011553984800_ref80) 2018; 50
Kikkawa (2019091011553984800_ref116) 2014; 44
References_xml – volume: 26
  start-page: 195
  issue: 4
  year: 2007
  ident: 2019091011553984800_ref32
  article-title: Intronic microRNA: discovery and biological implications
  publication-title: DNA Cell Biol
  doi: 10.1089/dna.2006.0558
– volume: 37
  start-page: 3146
  issue: 5
  year: 2017
  ident: 2019091011553984800_ref49
  article-title: MicroRNA-30a-5p suppresses epithelial-mesenchymal transition by targeting profilin-2 in high invasive non-small cell lung cancer cell lines
  publication-title: Oncol Rep
  doi: 10.3892/or.2017.5566
– volume: 8
  start-page: 57
  issue: 1
  year: 2017
  ident: 2019091011553984800_ref10
  article-title: Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells
  publication-title: J Cancer
  doi: 10.7150/jca.16723
– volume: 1
  start-page: 53
  issue: 1
  year: 2014
  ident: 2019091011553984800_ref133
  article-title: MicroRNAs in cancer biology and therapy: current status and perspectives
  publication-title: Genes Dis
  doi: 10.1016/j.gendis.2014.06.004
– volume: 4
  start-page: 230
  issue: 3
  year: 2012
  ident: 2019091011553984800_ref2
  article-title: Origins and evolution of microRNA genes in plant species
  publication-title: Genome Biol Evol
  doi: 10.1093/gbe/evs002
– volume: 7
  start-page: 8171
  issue: 1
  year: 2017
  ident: 2019091011553984800_ref8
  article-title: Evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-08502-z
– volume: 14
  start-page: 363
  issue: 1
  year: 2017
  ident: 2019091011553984800_ref71
  article-title: Low expression of microRNA-30c promotes prostate cancer cells invasion involved in downregulation of KRAS protein
  publication-title: Oncol Lett
  doi: 10.3892/ol.2017.6163
– volume: 19
  start-page: 73
  issue: 1
  year: 2013
  ident: 2019091011553984800_ref73
  article-title: miRNA-34b inhibits prostate cancer through demethylation, active chromatin modifications, and AKT pathways
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-12-2952
– volume: 12
  start-page: 3411
  issue: 5
  year: 2016
  ident: 2019091011553984800_ref111
  article-title: Downregulated miR-486-5p acts as a tumor suppressor in esophageal squamous cell carcinoma
  publication-title: Exp Ther Med
  doi: 10.3892/etm.2016.3783
– volume: 38
  start-page: 689
  issue: 5
  year: 2010
  ident: 2019091011553984800_ref115
  article-title: Negative regulation of tumor suppressor p53 by microRNA miR-504
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2010.05.027
– volume: 112
  start-page: E4288
  issue: 31
  year: 2015
  ident: 2019091011553984800_ref128
  article-title: MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1502068112
– volume: 19
  start-page: 1
  issue: 1
  year: 2017
  ident: 2019091011553984800_ref126
  article-title: Development of novel therapeutic agents by inhibition of oncogenic microRNAs
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms19010065
– volume: 31
  start-page: 1884
  issue: 15
  year: 2012
  ident: 2019091011553984800_ref81
  article-title: Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases
  publication-title: Oncogene
  doi: 10.1038/onc.2011.380
– volume: 42
  start-page: 411
  issue: 2
  year: 2013
  ident: 2019091011553984800_ref29
  article-title: Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2012.1724
– volume: 333
  start-page: 96
  issue: 1
  year: 2011
  ident: 2019091011553984800_ref13
  article-title: Coexpression of an intronic microRNA and its host gene reveals a potential role for miR-483-5p as an IGF2 partner
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2010.11.027
– volume: 2014
  start-page: 1
  year: 2014
  ident: 2019091011553984800_ref19
  article-title: miRIAD-integrating microRNA inter- and intragenic data
  publication-title: Database (Oxford)
  doi: 10.1093/database/bau099
– volume: 68
  start-page: 8191
  issue: 20
  year: 2008
  ident: 2019091011553984800_ref121
  article-title: Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-08-1768
– volume: 64
  start-page: 835
  issue: 10
  year: 2012
  ident: 2019091011553984800_ref12
  article-title: Enemy or partner: relationship between intronic micrornas and their host genes
  publication-title: IUBMB Life
  doi: 10.1002/iub.1079
– volume: 40
  start-page: 6821
  issue: 14
  year: 2012
  ident: 2019091011553984800_ref38
  article-title: A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gks308
– volume: 99
  start-page: 1326
  issue: 8
  year: 2014
  ident: 2019091011553984800_ref79
  article-title: MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia
  publication-title: Haematologica
  doi: 10.3324/haematol.2013.099515
– volume: 18
  start-page: 51
  year: 2018
  ident: 2019091011553984800_ref84
  article-title: Tumor-suppressor role of miR-139-5p in endometrial cancer
  publication-title: Cancer Cell Int
  doi: 10.1186/s12935-018-0545-8
– volume: 322
  start-page: 1849
  issue: 5909
  year: 2008
  ident: 2019091011553984800_ref17
  article-title: Divergent transcription from active promoters
  publication-title: Science
  doi: 10.1126/science.1162253
– volume: 116
  start-page: 281
  issue: 2
  year: 2004
  ident: 2019091011553984800_ref5
  article-title: MicroRNAs: genomics, biogenesis, mechanism, and function
  publication-title: Cell
  doi: 10.1016/S0092-8674(04)00045-5
– volume: 52
  start-page: E182
  issue: Suppl 3
  year: 2015
  ident: 2019091011553984800_ref94
  article-title: MicroRNA-185 is a novel tumor suppressor by negatively modulating the Wnt/beta-catenin pathway in human colorectal cancer
  publication-title: Indian J Cancer
  doi: 10.4103/0019-509X.186576
– volume: 8
  start-page: 93
  issue: 1
  year: 2014
  ident: 2019091011553984800_ref118
  article-title: High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth
  publication-title: Mol Oncol
  doi: 10.1016/j.molonc.2013.10.001
– volume: 7
  start-page: 5708
  issue: 1
  year: 2017
  ident: 2019091011553984800_ref77
  article-title: Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-06137-8
– volume: 15
  start-page: 5611
  issue: 4
  year: 2018
  ident: 2019091011553984800_ref46
  article-title: MicroRNA-10a/b are regulators of myeloid differentiation and acute myeloid leukemia
  publication-title: Oncol Lett
– volume: 302
  start-page: 1
  issue: 1
  year: 2007
  ident: 2019091011553984800_ref47
  article-title: microRNAs as oncogenes and tumor suppressors
  publication-title: Dev Biol
  doi: 10.1016/j.ydbio.2006.08.028
– volume: 103
  start-page: 782
  year: 2018
  ident: 2019091011553984800_ref109
  article-title: MicroRNA-449a functions as a tumor suppressor in pancreatic cancer by the epigenetic regulation of ATDC expression
  publication-title: Biomed Pharmacother
  doi: 10.1016/j.biopha.2018.04.101
– volume: 936
  start-page: 69
  year: 2013
  ident: 2019091011553984800_ref51
  article-title: Setting up an intronic miRNA database
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-62703-083-0_5
– volume: 34
  start-page: 111
  issue: 1
  year: 2015
  ident: 2019091011553984800_ref87
  article-title: MicroRNA-153 functions as a tumor suppressor by targeting SET7 and ZEB2 in ovarian cancer cells
  publication-title: Oncol Rep
  doi: 10.3892/or.2015.3952
– volume: 136
  start-page: 215
  issue: 2
  year: 2009
  ident: 2019091011553984800_ref1
  article-title: MicroRNAs: target recognition and regulatory functions
  publication-title: Cell
  doi: 10.1016/j.cell.2009.01.002
– volume: 36
  start-page: D154
  issue: Database issue
  year: 2008
  ident: 2019091011553984800_ref25
  article-title: miRBase: tools for microRNA genomics
  publication-title: Nucleic Acids Res
– volume: 33
  start-page: 3307
  issue: 25
  year: 2014
  ident: 2019091011553984800_ref129
  article-title: Therapeutic implications of activation of the host gene (Dleu2) promoter for miR-15a/16-1 in chronic lymphocytic leukemia
  publication-title: Oncogene
  doi: 10.1038/onc.2013.291
– volume: 12
  start-page: 247
  issue: 3
  year: 2010
  ident: 2019091011553984800_ref55
  article-title: miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb2024
– volume: 50
  start-page: 171
  issue: 2
  year: 2018
  ident: 2019091011553984800_ref80
  article-title: Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer
  publication-title: Acta Biochim Biophys Sin (Shanghai)
  doi: 10.1093/abbs/gmx132
– volume: 11
  start-page: 241
  issue: 3
  year: 2005
  ident: 2019091011553984800_ref26
  article-title: Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes
  publication-title: RNA
  doi: 10.1261/rna.7240905
– volume: 25
  start-page: 6188
  issue: 46
  year: 2006
  ident: 2019091011553984800_ref58
  article-title: A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209913
– volume: 13
  start-page: 1438
  issue: 11
  year: 2017
  ident: 2019091011553984800_ref31
  article-title: Transcriptome integration analysis in hepatocellular carcinoma reveals discordant intronic miRNA-host gene pairs in expression
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.20836
– volume: 47
  start-page: 1594
  issue: 4
  year: 2015
  ident: 2019091011553984800_ref105
  article-title: MicroRNA-338-3p functions as tumor suppressor in breast cancer by targeting SOX4
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2015.3114
– volume: 8
  start-page: 2557
  issue: 16
  year: 2009
  ident: 2019091011553984800_ref18
  article-title: Divergent transcription: a new feature of active promoters
  publication-title: Cell Cycle
  doi: 10.4161/cc.8.16.9305
– volume: 379
  start-page: 726
  issue: 3
  year: 2009
  ident: 2019091011553984800_ref130
  article-title: Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2008.12.098
– volume: 50
  start-page: 869
  issue: 6
  year: 2013
  ident: 2019091011553984800_ref39
  article-title: Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2013.05.007
– volume: 26
  start-page: 775
  issue: 3
  year: 2007
  ident: 2019091011553984800_ref27
  article-title: Processing of intronic microRNAs
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7601512
– volume: 183
  start-page: 743
  issue: 2
  year: 2010
  ident: 2019091011553984800_ref59
  article-title: The miR-17-92 cluster is over expressed in and has an oncogenic effect on renal cell carcinoma
  publication-title: J Urol
  doi: 10.1016/j.juro.2009.09.086
– volume: 3
  start-page: 1
  issue: e126
  year: 2014
  ident: 2019091011553984800_ref44
  article-title: The enemy within: regulation of host genes by intronic microRNAs
  publication-title: Chemotherapy
– volume: 68
  start-page: 2094
  issue: 7
  year: 2008
  ident: 2019091011553984800_ref82
  article-title: Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-5194
– volume: 5
  start-page: 851
  issue: 11
  year: 2014
  ident: 2019091011553984800_ref85
  article-title: MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1
  publication-title: Protein Cell
  doi: 10.1007/s13238-014-0093-5
– volume: 9
  start-page: 9706
  issue: 9
  year: 2016
  ident: 2019091011553984800_ref95
  article-title: MiR-186 acts as a tumor suppressor by targeting TWIST1/2 and regulating the epithelial-mesenchymal transition in glioblastoma multiforme
  publication-title: Int J Clin Exp Pathol
– volume: 18
  start-page: 1511
  issue: 10
  year: 2012
  ident: 2019091011553984800_ref54
  article-title: LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker
  publication-title: Nat Med
  doi: 10.1038/nm.2940
– volume: 45
  start-page: e121
  issue: 13
  year: 2017
  ident: 2019091011553984800_ref76
  article-title: Identification of active miRNA promoters from nuclear run-on RNA sequencing
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkx318
– volume: 49
  start-page: 5
  issue: 1
  year: 2016
  ident: 2019091011553984800_ref125
  article-title: Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: new trends in the development of miRNA therapeutic strategies in oncology (Review)
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2016.3503
– volume: 95
  start-page: 1759
  year: 2017
  ident: 2019091011553984800_ref88
  article-title: MiRNA-155 promotes proliferation by targeting caudal-type homeobox 1 (CDX1) in glioma cells
  publication-title: Biomed Pharmacother
  doi: 10.1016/j.biopha.2017.08.088
– volume: 39
  start-page: 293
  issue: 2
  year: 2018
  ident: 2019091011553984800_ref45
  article-title: MicroRNA-128-3p-mediated depletion of Drosha promotes lung cancer cell migration
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgx134
– volume: 8
  start-page: 60243
  issue: 36
  year: 2017
  ident: 2019091011553984800_ref72
  article-title: miR-33a is a tumor suppressor microRNA that is decreased in prostate cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.19521
– volume: 11
  start-page: 533
  year: 2010
  ident: 2019091011553984800_ref15
  article-title: A potential role for intragenic miRNAs on their hosts' interactome
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-11-533
– volume: 97
  start-page: 1
  issue: 1
  year: 2011
  ident: 2019091011553984800_ref33
  article-title: Transcriptional regulation of mammalian miRNA genes
  publication-title: Genomics
  doi: 10.1016/j.ygeno.2010.10.005
– volume: 71
  start-page: 6450
  issue: 20
  year: 2011
  ident: 2019091011553984800_ref67
  article-title: miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-11-0364
– volume: 117
  start-page: 2842
  issue: 13
  year: 2011
  ident: 2019091011553984800_ref106
  article-title: miR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met
  publication-title: Cancer
  doi: 10.1002/cncr.25860
– volume: 13
  start-page: 2537
  year: 2008
  ident: 2019091011553984800_ref4
  article-title: Protein interactions and complexes in human microRNA biogenesis and function
  publication-title: Front Biosci
  doi: 10.2741/2865
– volume: 39
  start-page: D152
  issue: Database issue
  year: 2011
  ident: 2019091011553984800_ref22
  article-title: miRBase: integrating microRNA annotation and deep-sequencing data
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkq1027
– volume: 9
  start-page: 114
  year: 2017
  ident: 2019091011553984800_ref103
  article-title: MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
  publication-title: Clin Epigenetics
  doi: 10.1186/s13148-017-0413-8
– volume: 105
  start-page: 16230
  issue: 42
  year: 2008
  ident: 2019091011553984800_ref41
  article-title: MicroRNA-directed transcriptional gene silencing in mammalian cells
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0808830105
– volume: 16
  start-page: 86
  year: 2016
  ident: 2019091011553984800_ref64
  article-title: Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers
  publication-title: BMC Cancer
  doi: 10.1186/s12885-016-2109-4
– volume: 42
  start-page: D68
  issue: Database issue
  year: 2014
  ident: 2019091011553984800_ref21
  article-title: miRBase: annotating high confidence microRNAs using deep sequencing data
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt1181
– volume: 6
  start-page: 1
  year: 2016
  ident: 2019091011553984800_ref74
  article-title: Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by targeting p21 expression
  publication-title: Sci Rep
  doi: 10.1038/srep34034
– volume: 99
  start-page: 15524
  issue: 24
  year: 2002
  ident: 2019091011553984800_ref6
  article-title: Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.242606799
– volume: 3
  start-page: 15033
  year: 2015
  ident: 2019091011553984800_ref68
  article-title: MicroRNA-26a inhibits osteosarcoma cell proliferation by targeting IGF-1
  publication-title: Bone Res
  doi: 10.1038/boneres.2015.33
– volume: 2015
  start-page: 1
  year: 2015
  ident: 2019091011553984800_ref9
  article-title: CRISPR/CAS9-mediated genome editing of miRNA-155 inhibits proinflammatory cytokine production by RAW264.7 cells
  publication-title: Biomed Res Int
  doi: 10.1155/2015/326042
– volume: 6
  start-page: 2021
  issue: 9
  year: 2016
  ident: 2019091011553984800_ref113
  article-title: miR-489 acts as a tumor suppressor in human gastric cancer by targeting PROX1
  publication-title: Am J Cancer Res
– volume: 20
  start-page: 2169
  issue: 8
  year: 2014
  ident: 2019091011553984800_ref122
  article-title: Hypermethylation of the GABRE~miR-452~miR-224 promoter in prostate cancer predicts biochemical recurrence after radical prostatectomy
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-13-2642
– volume: 25
  start-page: 226
  issue: 3
  year: 2011
  ident: 2019091011553984800_ref119
  article-title: MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer
  publication-title: Genes Dev
  doi: 10.1101/gad.1974211
– volume: 7
  start-page: 8341
  issue: 7
  year: 2016
  ident: 2019091011553984800_ref100
  article-title: miR-326 targets CCND1 and inhibits non-small cell lung cancer development
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.7071
– volume: 26
  start-page: 25
  issue: 1
  year: 2012
  ident: 2019091011553984800_ref43
  article-title: Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2
  publication-title: Genes Dev
  doi: 10.1101/gad.177774.111
– volume: 10
  start-page: 1224
  issue: 12
  year: 2010
  ident: 2019091011553984800_ref61
  article-title: MicroRNA-21: a novel therapeutic target in human cancer
  publication-title: Cancer Biol Ther
  doi: 10.4161/cbt.10.12.14252
– volume: 34
  start-page: 2557
  issue: 5
  year: 2015
  ident: 2019091011553984800_ref124
  article-title: Downregulation of VMP1 confers aggressive properties to colorectal cancer
  publication-title: Oncol Rep
  doi: 10.3892/or.2015.4240
– start-page: 1
  year: 2010
  ident: 2019091011553984800_ref23
  article-title: miRBase: microRNA sequences and annotation
  publication-title: Curr Protoc Bioinformatics
– volume: 12
  start-page: 14
  year: 2012
  ident: 2019091011553984800_ref65
  article-title: miR-21 may acts as an oncomir by targeting RECK, a matrix metalloproteinase regulator, in prostate cancer
  publication-title: BMC Urol
  doi: 10.1186/1471-2490-12-14
– volume: 282
  start-page: 14328
  issue: 19
  year: 2007
  ident: 2019091011553984800_ref62
  article-title: MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M611393200
– volume: 2016
  start-page: 1
  year: 2016
  ident: 2019091011553984800_ref89
  article-title: miR-155 as a biomarker in B-cell malignancies
  publication-title: Biomed Res Int
  doi: 10.1155/2016/9513037
– volume: 8
  start-page: 8342
  issue: 5
  year: 2017
  ident: 2019091011553984800_ref34
  article-title: MicroRNA-1908-5p contributes to the oncogenic function of the splicing factor SRSF3
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.14184
– volume: 8
  start-page: 1
  issue: 6
  year: 2017
  ident: 2019091011553984800_ref69
  article-title: Tumor-suppressive miR-26a and miR-26b inhibit cell aggressiveness by regulating FUT4 in colorectal cancer
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2017.281
– volume: 27
  start-page: 3880
  issue: 27
  year: 2008
  ident: 2019091011553984800_ref107
  article-title: Epigenetic silencing of the intronic microRNA miR-342 and its host gene EVL in colorectal cancer
  publication-title: Oncogene
  doi: 10.1038/onc.2008.10
– volume: 106
  start-page: 7113
  issue: 17
  year: 2009
  ident: 2019091011553984800_ref91
  article-title: Inositol phosphatase SHIP1 is a primary target of miR-155
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0902636106
– volume: 44
  start-page: 2085
  issue: 6
  year: 2014
  ident: 2019091011553984800_ref116
  article-title: microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2014.2349
– volume: 8
  start-page: 45
  issue: 1
  year: 2017
  ident: 2019091011553984800_ref7
  article-title: Role of microRNAs in translation regulation and cancer
  publication-title: World J Biol Chem
  doi: 10.4331/wjbc.v8.i1.45
– year: 2012
  ident: 2019091011553984800_ref110
  article-title: Combinatorial analysis of tumorigenic microRNAs driving prostate cancer
– volume: 26
  start-page: 655
  issue: 6
  year: 2016
  ident: 2019091011553984800_ref14
  article-title: CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance
  publication-title: Cell Res
  doi: 10.1038/cr.2016.32
– volume: 374
  start-page: 1
  issue: 1
  year: 2016
  ident: 2019091011553984800_ref117
  article-title: A tumor-suppressive microRNA, miR-504, inhibits cell proliferation and promotes apoptosis by targeting FOXP1 in human glioma
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2016.01.051
– volume: 26
  start-page: 2451
  issue: 13
  year: 2017
  ident: 2019091011553984800_ref127
  article-title: Clinical significance of miRNA host gene promoter methylation in prostate cancer
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddx138
– volume: 30
  start-page: 701
  issue: 2
  year: 2013
  ident: 2019091011553984800_ref102
  article-title: miR-335 represents an invasion suppressor gene in ovarian cancer by targeting Bcl-w
  publication-title: Oncol Rep
  doi: 10.3892/or.2013.2482
– volume: 33
  start-page: 1290
  issue: 4
  year: 2005
  ident: 2019091011553984800_ref50
  article-title: Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gki200
– volume: 35
  start-page: 3178
  issue: 6
  year: 2016
  ident: 2019091011553984800_ref98
  article-title: Tumor-suppressing roles of miR-214 and miR-218 in breast cancer
  publication-title: Oncol Rep
  doi: 10.3892/or.2016.4749
– volume: 127
  start-page: 1072
  issue: 5
  year: 2010
  ident: 2019091011553984800_ref114
  article-title: Functional screening identifies a microRNA, miR-491 that induces apoptosis by targeting Bcl-X(L) in colorectal cancer cells
  publication-title: Int J Cancer
  doi: 10.1002/ijc.25143
– volume: 4
  start-page: 1651
  issue: 8
  year: 2015
  ident: 2019091011553984800_ref3
  article-title: MicroRNA processing and human cancer
  publication-title: J Clin Med
  doi: 10.3390/jcm4081651
– volume: 16
  start-page: 215
  year: 2016
  ident: 2019091011553984800_ref63
  article-title: Relevance of miR-21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells
  publication-title: BMC Cancer
  doi: 10.1186/s12885-016-2231-3
– volume: 133
  start-page: 647
  issue: 2
  year: 2007
  ident: 2019091011553984800_ref60
  article-title: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2007.05.022
– volume: 5
  start-page: 5700
  year: 2014
  ident: 2019091011553984800_ref16
  article-title: microTSS: accurate microRNA transcription start site identification reveals a significant number of divergent pri-miRNAs
  publication-title: Nat Commun
  doi: 10.1038/ncomms6700
– volume: 434
  start-page: 473
  issue: 3
  year: 2011
  ident: 2019091011553984800_ref123
  article-title: Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells
  publication-title: Biochem J
  doi: 10.1042/BJ20101585
– volume: 39
  start-page: 23
  issue: 1
  year: 2016
  ident: 2019091011553984800_ref75
  article-title: miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway
  publication-title: Cell Oncol (Dordr)
  doi: 10.1007/s13402-015-0247-3
– volume: 133
  start-page: 1064
  issue: 5
  year: 2013
  ident: 2019091011553984800_ref83
  article-title: MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A
  publication-title: Int J Cancer
  doi: 10.1002/ijc.28091
– volume: 123
  start-page: 150
  issue: 1
  year: 2013
  ident: 2019091011553984800_ref93
  article-title: TGF-beta upregulates miR-181a expression to promote breast cancer metastasis
  publication-title: J Clin Invest
  doi: 10.1172/JCI64946
– volume: 515
  start-page: 355
  issue: 7527
  year: 2014
  ident: 2019091011553984800_ref92
  article-title: A comparative encyclopedia of DNA elements in the mouse genome
  publication-title: Nature
  doi: 10.1038/nature13992
– volume: 5
  start-page: 7748
  issue: 17
  year: 2014
  ident: 2019091011553984800_ref70
  article-title: The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.2294
– volume: 96
  start-page: E1388
  issue: 9
  year: 2011
  ident: 2019091011553984800_ref52
  article-title: MiR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1alpha
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2011-0345
– volume: 342
  start-page: 129
  year: 2006
  ident: 2019091011553984800_ref24
  article-title: miRBase: the microRNA sequence database
  publication-title: Methods Mol Biol
– volume: 8
  start-page: 37321
  issue: 23
  year: 2017
  ident: 2019091011553984800_ref56
  article-title: Transcriptome profiling reveals miR-9-3p as a novel tumor suppressor in gastric cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.16310
– volume: 16
  start-page: 117
  issue: 1
  year: 2017
  ident: 2019091011553984800_ref97
  article-title: Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-kappaB signaling pathway
  publication-title: Mol Cancer
  doi: 10.1186/s12943-017-0688-6
– volume: 495
  start-page: 103
  issue: 7439
  year: 2013
  ident: 2019091011553984800_ref37
  article-title: ‘See-saw’ expression of microRNA-198 and FSTL1 from a single transcript in wound healing
  publication-title: Nature
  doi: 10.1038/nature11890
– volume: 22
  start-page: 3172
  issue: 22
  year: 2008
  ident: 2019091011553984800_ref35
  article-title: Chromatin structure analyses identify miRNA promoters
  publication-title: Genes Dev
  doi: 10.1101/gad.1706508
– volume: 7
  start-page: 1849
  issue: 5
  year: 2014
  ident: 2019091011553984800_ref53
  article-title: miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer
  publication-title: Int J Clin Exp Pathol
– volume: 179
  start-page: 5082
  issue: 8
  year: 2007
  ident: 2019091011553984800_ref90
  article-title: Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.8.5082
– volume: 42
  start-page: 4640
  issue: 7
  year: 2014
  ident: 2019091011553984800_ref36
  article-title: Interplay between pre-mRNA splicing and microRNA biogenesis within the supraspliceosome
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt1413
– volume: 17
  start-page: 28
  year: 2017
  ident: 2019091011553984800_ref120
  article-title: Up-regulation of CRKL by microRNA-335 methylation is associated with poor prognosis in gastric cancer
  publication-title: Cancer Cell Int
  doi: 10.1186/s12935-017-0387-9
– volume: 70
  start-page: 6925
  issue: 17
  year: 2010
  ident: 2019091011553984800_ref101
  article-title: miR-335 directly targets Rb1 (pRb/p105) in a proximal connection to p53-dependent stress response
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-0141
– volume: 40
  start-page: 4002
  issue: 9
  year: 2012
  ident: 2019091011553984800_ref11
  article-title: Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkr1312
– volume: 10
  start-page: 3
  issue: 1
  year: 2012
  ident: 2019091011553984800_ref78
  article-title: MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-11-0272
– volume: 33
  start-page: 11
  issue: 1
  year: 2011
  ident: 2019091011553984800_ref30
  article-title: MicroRNAs: tiny targets for engineering CHO cell phenotypes?
  publication-title: Biotechnol Lett
  doi: 10.1007/s10529-010-0415-5
– volume: 13
  start-page: 1753
  issue: 3
  year: 2017
  ident: 2019091011553984800_ref96
  article-title: miR-198 functions as a tumor suppressor in breast cancer by targeting CUB domain-containing protein 1
  publication-title: Oncol Lett
  doi: 10.3892/ol.2017.5673
– volume: 8
  start-page: 1
  issue: 5
  year: 2013
  ident: 2019091011553984800_ref99
  article-title: Multiple-to-multiple relationships between microRNAs and target genes in gastric cancer
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0062589
– volume: 7
  issue: 2
  year: 2012
  ident: 2019091011553984800_ref42
  article-title: A potential regulatory role for intronic microRNA-338-3p for its host gene encoding apoptosis-associated tyrosine kinase
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0031022
– volume: 4
  start-page: 1
  issue: 4
  year: 2009
  ident: 2019091011553984800_ref28
  article-title: Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0005279
– volume: 37
  start-page: 8691
  issue: 7
  year: 2016
  ident: 2019091011553984800_ref112
  article-title: miR-488 acts as a tumor suppressor gene in gastric cancer
  publication-title: Tumour Biol
  doi: 10.1007/s13277-015-4645-y
– volume: 15
  start-page: 1436
  issue: 7
  year: 2016
  ident: 2019091011553984800_ref132
  article-title: An artificially designed interfering lncRNA expressed by oncolytic adenovirus competitively consumes oncomiRs to exert antitumor efficacy in hepatocellular carcinoma
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-16-0096
– volume: 11
  start-page: 224
  year: 2010
  ident: 2019091011553984800_ref20
  article-title: Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-11-224
– volume: 9
  start-page: 775
  issue: 10
  year: 2010
  ident: 2019091011553984800_ref131
  article-title: Targeting microRNAs in cancer: rationale, strategies and challenges
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd3179
– volume: 11
  start-page: 537
  issue: 7
  year: 2010
  ident: 2019091011553984800_ref57
  article-title: MicroRNA: biogenesis, function and role in cancer
  publication-title: Curr Genomics
  doi: 10.2174/138920210793175895
– volume: 8
  start-page: 65218
  issue: 39
  year: 2017
  ident: 2019091011553984800_ref108
  article-title: MiR-346 suppresses cell proliferation through SMYD3 dependent approach in hepatocellular carcinoma
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.18060
– volume: 10
  start-page: 42
  year: 2015
  ident: 2019091011553984800_ref66
  article-title: miR-23b as a potential tumor suppressor and its regulation by DNA methylation in cervical cancer
  publication-title: Infect Agent Cancer
  doi: 10.1186/s13027-015-0037-6
– volume: 68
  start-page: 4123
  issue: 11
  year: 2008
  ident: 2019091011553984800_ref40
  article-title: Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-08-0325
– volume: 50
  start-page: 1461
  issue: 5
  year: 2017
  ident: 2019091011553984800_ref48
  article-title: MicroRNAs driving invasion and metastasis in ovarian cancer: opportunities for translational medicine (Review)
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2017.3948
– volume: 74
  start-page: 5256
  issue: 18
  year: 2014
  ident: 2019091011553984800_ref86
  article-title: miR149 functions as a tumor suppressor by controlling breast epithelial cell migration and invasion
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-13-3319
– volume: 36
  start-page: 6313
  issue: 8
  year: 2015
  ident: 2019091011553984800_ref104
  article-title: MiR-335 acts as a potential tumor suppressor miRNA via downregulating ROCK1 expression in hepatocellular carcinoma
  publication-title: Tumour Biol
  doi: 10.1007/s13277-015-3317-2
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Snippet MicroRNAs (miRNAs) are small endogenous non-coding functional RNAs that post-transcriptionally regulate gene expression. They play essential roles in nearly...
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SubjectTerms Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
MicroRNAs - metabolism
Neoplasms - genetics
Oncogenes
Review Paper
Title Interplay between miRNAs and host genes and their role in cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/30785618
https://www.proquest.com/docview/2184145171
https://pubmed.ncbi.nlm.nih.gov/PMC6609535
Volume 18
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