Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target

• Published in: JNCI : Journal of the National Cancer Institute Vol. 108; no. 5; p. djv371
• Main Authors: Asim, Mohammad, Massie, Charles E, Orafidiya, Folake, Pértega-Gomes, Nelma, Warren, Anne Y, Esmaeili, Mohsen, Selth, Luke A, Zecchini, Heather I, Luko, Katarina, Qureshi, Arham, Baridi, Ajoeb, Menon, Suraj, Madhu, Basetti, Escriu, Carlos, Lyons, Scott, Vowler, Sarah L, Zecchini, Vincent R, Shaw, Greg, Hessenkemper, Wiebke, Russell, Roslin, Mohammed, Hisham, Stefanos, Niki, Lynch, Andy G, Grigorenko, Elena, D'Santos, Clive, Taylor, Chris, Lamb, Alastair, Sriranjan, Rouchelle, Yang, Jiali, Stark, Rory, Dehm, Scott M, Rennie, Paul S, Carroll, Jason S, Griffiths, John R, Tavaré, Simon, Mills, Ian G, McEwan, Iain J, Baniahmad, Aria, Tilley, Wayne D, Neal, David E
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2016
• Subjects: Aged; Animals; Antineoplastic Agents - pharmacology; Biomarkers, Tumor - metabolism; Choline Kinase - antagonists & inhibitors; Choline Kinase - genetics; Choline Kinase - metabolism; Enzyme Inhibitors - pharmacology; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Molecular Chaperones; Molecular Targeted Therapy - methods; Neoplasm Grading; Neoplasm Staging; Proportional Hazards Models; Prostatectomy - methods; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - enzymology; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Receptors, Androgen - metabolism; Sequence Analysis, DNA; Signal Transduction; Xenograft Model Antitumor Assays

The androgen receptor (AR) is a major drug target in prostate cancer (PCa). We profiled the AR-regulated kinome to identify clinically relevant and druggable effectors of AR signaling. Using genome-wide approaches, we interrogated all AR regulated kinases. Among these, choline kinase alpha (CHKA) ex...