Somatostatin analogues and the risk of post-operative pancreatic fistulas after pancreatic resection - A systematic review & meta-analysis

• Published in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 20; no. 2; pp. 158 - 168
• Main Authors: Li, Tianpei, D’Cruz, Reuban Toby, Lim, Sheng Yang, Shelat, Vishal G.
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 01.03.2020; Elsevier Limited
• Subjects: Abdomen; Bias; Clinical trials; Distal pancreatectomy; Fistula; Humans; Incidence; Literature reviews; Meta-analysis; Morbidity; Mortality; Octreotide; Pancreas; Pancreas - surgery; Pancreatic fistula; Pancreatic Fistula - epidemiology; Pancreatic Fistula - etiology; Pancreatic Fistula - prevention & control; Pancreatic resection; Pancreaticoduodenectomy; Pancreatitis; Pasireotide; Post-operative; Postoperative Complications - epidemiology; Postoperative Complications - prevention & control; Prophylaxis; Risk Assessment; Somatostatin; Somatostatin - analogs & derivatives; Somatostatin - therapeutic use; Somatostatin analogues; Studies; Surgery; Systematic review; Tumors; Whipple’s procedure; Somatostatin analogues; Pancreatic resection; Octreotide; Distal pancreatectomy; Post-operative; Pancreaticoduodenectomy; Pasireotide; Pancreatic fistula; Whipple’s procedure

Post-operative pancreatic fistula (POPF) is a common complication of pancreatic resection. Somatostatin analogues (SA) have been used as prophylaxis to reduce its incidence. The aim of this study is to appraise the current literature on the effects of SA prophylaxis on the prevention of POPF followi...