Fibroblast Growth Factor (FGF) Signaling Protects Against Acute Pancreatitis-Induced Damage by Modulating Inflammatory Responses

• Published in: Medical science monitor Vol. 26; pp. e920684 - e920684-10
• Main Authors: Tu, Hai-Jian, Zhao, Cheng-Fei, Chen, Zhi-wei, Lin, Wei, Jiang, Yu-Cai
• Format: Journal Article
• Language: English
• Published: United States International Scientific Literature, Inc 13.04.2020
• Subjects: Acute Disease; Adult; Amylases - metabolism; Animals; C-Reactive Protein - analysis; Case-Control Studies; Dinoprostone - blood; Female; Fibroblast Growth Factor 1 - blood; Fibroblast Growth Factor 1 - metabolism; Fibroblast Growth Factor 2 - blood; Fibroblast Growth Factor 2 - metabolism; Humans; Inflammation - metabolism; Inflammation - pathology; Lab/In Vitro Research; Lipase - metabolism; Male; Middle Aged; NF-KappaB Inhibitor alpha - blood; Nitriles - pharmacology; Pancreatitis - pathology; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfones - pharmacology; Tumor Necrosis Factor-alpha - blood

BACKGROUND Acute pancreatitis (AP) is a symptom of sudden pancreas inflammation, which causes patients severe suffering. In general, fibroblast growth factor (FGF) levels are increased and amylase and lipase activities are elevated during AP pathogenesis, but protein concentration are low. However,...