Transdermal Nicotine for Analgesia After Radical Retropubic Prostatectomy
Previous animal and human studies suggested that nicotine might have an antinociceptive effect. We hypothesized that the preoperative application of a 7 mg nicotine patch would result in reduced postoperative analgesic requirements in patients undergoing radical retropubic prostatectomy (RRP) under...
Saved in:
Published in | Anesthesia and analgesia Vol. 107; no. 3; pp. 999 - 1004 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hagerstown, MD
Lippincott
01.09.2008
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Previous animal and human studies suggested that nicotine might have an antinociceptive effect. We hypothesized that the preoperative application of a 7 mg nicotine patch would result in reduced postoperative analgesic requirements in patients undergoing radical retropubic prostatectomy (RRP) under general anesthesia.
Nonsmokers undergoing RRP under general anesthesia were enrolled in this prospective, double-blind, placebo-controlled study. Patients were randomly assigned to receive a patch of 7 mg nicotine or placebo applied behind the ear 30-60 min before induction of anesthesia. The anesthetic technique was standardized. Postoperative analgesia was provided with a standardized morphine patient-controlled analgesia and 6 hourly ketorolac 15 mg IV. Data were collected in the postanesthesia care unit and at 6, 12, and 24 h after surgery.
Ninety patients were included in the analysis: 44 in the nicotine group and 46 in the placebo group. The groups did not differ significantly with respect to age, height, weight, ASA class, length of surgery, or amounts of intraoperative fentanyl received. The nicotine group showed significantly lower cumulative morphine consumption at 24 h (mean +/- sd): 33.3 +/- 30.8 mg vs 44.7 +/- 26.4 mg (P = 0.0059, time x treatment P = 0.0031). However, the repeated measures tests found no difference in amount of pain reported on coughing or at rest, either as treatment effects or in interaction with time. In post hoc comparisons, there was no significant difference in amount of pain reported on coughing or at rest at any of the times assessed. There were also no significant differences between the groups in the incidence of postoperative nausea and vomiting or the need for rescue antiemetics. However, the maximum nausea verbal rating scale score was higher in the nicotine than in the placebo group (median, 25th to 75th percentiles = 4, 0-6 vs 0, 0-6, P = 0.0158). There was a significant negative correlation between the 24 h plasma nicotine levels and postoperative morphine consumption in the postanesthesia care unit (P = 0.049), as well as at 6, 12, and 24 h (P = 0.002).
The preoperative application of a 7 mg nicotine patch resulted in a significant reduction in opioid consumption in patients undergoing RRP under general anesthesia. Despite this reduction in opioid use, there was no reduction in pain scores or postoperative nausea and vomiting with the use of transdermal nicotine. |
---|---|
AbstractList | Previous animal and human studies suggested that nicotine might have an antinociceptive effect. We hypothesized that the preoperative application of a 7 mg nicotine patch would result in reduced postoperative analgesic requirements in patients undergoing radical retropubic prostatectomy (RRP) under general anesthesia.
Nonsmokers undergoing RRP under general anesthesia were enrolled in this prospective, double-blind, placebo-controlled study. Patients were randomly assigned to receive a patch of 7 mg nicotine or placebo applied behind the ear 30-60 min before induction of anesthesia. The anesthetic technique was standardized. Postoperative analgesia was provided with a standardized morphine patient-controlled analgesia and 6 hourly ketorolac 15 mg IV. Data were collected in the postanesthesia care unit and at 6, 12, and 24 h after surgery.
Ninety patients were included in the analysis: 44 in the nicotine group and 46 in the placebo group. The groups did not differ significantly with respect to age, height, weight, ASA class, length of surgery, or amounts of intraoperative fentanyl received. The nicotine group showed significantly lower cumulative morphine consumption at 24 h (mean +/- sd): 33.3 +/- 30.8 mg vs 44.7 +/- 26.4 mg (P = 0.0059, time x treatment P = 0.0031). However, the repeated measures tests found no difference in amount of pain reported on coughing or at rest, either as treatment effects or in interaction with time. In post hoc comparisons, there was no significant difference in amount of pain reported on coughing or at rest at any of the times assessed. There were also no significant differences between the groups in the incidence of postoperative nausea and vomiting or the need for rescue antiemetics. However, the maximum nausea verbal rating scale score was higher in the nicotine than in the placebo group (median, 25th to 75th percentiles = 4, 0-6 vs 0, 0-6, P = 0.0158). There was a significant negative correlation between the 24 h plasma nicotine levels and postoperative morphine consumption in the postanesthesia care unit (P = 0.049), as well as at 6, 12, and 24 h (P = 0.002).
The preoperative application of a 7 mg nicotine patch resulted in a significant reduction in opioid consumption in patients undergoing RRP under general anesthesia. Despite this reduction in opioid use, there was no reduction in pain scores or postoperative nausea and vomiting with the use of transdermal nicotine. BACKGROUNDPrevious animal and human studies suggested that nicotine might have an antinociceptive effect. We hypothesized that the preoperative application of a 7 mg nicotine patch would result in reduced postoperative analgesic requirements in patients undergoing radical retropubic prostatectomy (RRP) under general anesthesia.METHODSNonsmokers undergoing RRP under general anesthesia were enrolled in this prospective, double-blind, placebo-controlled study. Patients were randomly assigned to receive a patch of 7 mg nicotine or placebo applied behind the ear 30-60 min before induction of anesthesia. The anesthetic technique was standardized. Postoperative analgesia was provided with a standardized morphine patient-controlled analgesia and 6 hourly ketorolac 15 mg IV. Data were collected in the postanesthesia care unit and at 6, 12, and 24 h after surgery.RESULTSNinety patients were included in the analysis: 44 in the nicotine group and 46 in the placebo group. The groups did not differ significantly with respect to age, height, weight, ASA class, length of surgery, or amounts of intraoperative fentanyl received. The nicotine group showed significantly lower cumulative morphine consumption at 24 h (mean +/- sd): 33.3 +/- 30.8 mg vs 44.7 +/- 26.4 mg (P = 0.0059, time x treatment P = 0.0031). However, the repeated measures tests found no difference in amount of pain reported on coughing or at rest, either as treatment effects or in interaction with time. In post hoc comparisons, there was no significant difference in amount of pain reported on coughing or at rest at any of the times assessed. There were also no significant differences between the groups in the incidence of postoperative nausea and vomiting or the need for rescue antiemetics. However, the maximum nausea verbal rating scale score was higher in the nicotine than in the placebo group (median, 25th to 75th percentiles = 4, 0-6 vs 0, 0-6, P = 0.0158). There was a significant negative correlation between the 24 h plasma nicotine levels and postoperative morphine consumption in the postanesthesia care unit (P = 0.049), as well as at 6, 12, and 24 h (P = 0.002).CONCLUSIONThe preoperative application of a 7 mg nicotine patch resulted in a significant reduction in opioid consumption in patients undergoing RRP under general anesthesia. Despite this reduction in opioid use, there was no reduction in pain scores or postoperative nausea and vomiting with the use of transdermal nicotine. |
Author | HABIB, Ashraf S WHITE, William D SALEH, Gamal POLASCIK, Thomas J MOUL, Judd W EL GASIM, Magdi A CAN, Tong J |
Author_xml | – sequence: 1 givenname: Ashraf S surname: HABIB fullname: HABIB, Ashraf S organization: Department of Anesthesiology, Duke University Medical System, Durham, North Carolina, United States – sequence: 2 givenname: William D surname: WHITE fullname: WHITE, William D organization: Department of Anesthesiology, Duke University Medical System, Durham, North Carolina, United States – sequence: 3 givenname: Magdi A surname: EL GASIM fullname: EL GASIM, Magdi A organization: Department of Anesthesiology, Duke University Medical System, Durham, North Carolina, United States – sequence: 4 givenname: Gamal surname: SALEH fullname: SALEH, Gamal organization: Department of Anesthesiology, Duke University Medical System, Durham, North Carolina, United States – sequence: 5 givenname: Thomas J surname: POLASCIK fullname: POLASCIK, Thomas J organization: Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical System, Durham, North Carolina, United States – sequence: 6 givenname: Judd W surname: MOUL fullname: MOUL, Judd W organization: Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical System, Durham, North Carolina, United States – sequence: 7 givenname: Tong J surname: CAN fullname: CAN, Tong J organization: Department of Anesthesiology, Duke University Medical System, Durham, North Carolina, United States |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20606076$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18713920$$D View this record in MEDLINE/PubMed |
BookMark | eNpdkEtLAzEQx4NU7EO_gche9LY1j91scizFR6GolHpesslEVvZRk-yh395IFwWZw8zA7z8MvzmadH0HCF0TvCSUsHvVwRJXmDBgRBBuKSf8DM1ITnla5FJM0AxjzFIqpZyiufefcSVY8As0JaIgTFI8Q5u9U5034FrVJC-17kPdQWJ7l6w61XyAr1WysgFcslOm1hHaQXD9Yahqnby53gcVQIe-PV6ic6saD1djX6D3x4f9-jndvj5t1qttqpkgIc0EKKtlpTgFKpgBSaw1lcZamKxgVUYgJ9IUhamktQzHMQPNcqFpxhhXbIHuTncPrv8awIeyrb2GpolC-sGXXGaZZKyIYHYCdXzTO7DlwdWtcseS4PJHYRkT5X-FMXYz3h-qFsxfaHQWgdsRUD4KsVGgrv0vRzGPVXD2Dac3fXM |
CODEN | AACRAT |
CitedBy_id | crossref_primary_10_1007_s00228_023_03475_7 crossref_primary_10_1016_j_ijom_2019_08_013 crossref_primary_10_1016_j_mehy_2014_06_011 crossref_primary_10_3390_ph16121665 crossref_primary_10_1007_s00384_017_2839_z crossref_primary_10_1016_j_joms_2010_07_025 crossref_primary_10_1097_AJP_0000000000000472 crossref_primary_10_1213_ANE_0000000000000002 crossref_primary_10_1016_j_jep_2021_114243 crossref_primary_10_1016_j_egja_2016_05_002 crossref_primary_10_1002_14651858_CD009634_pub2 crossref_primary_10_1111_j_1399_6576_2009_02140_x crossref_primary_10_1186_s12871_015_0137_2 crossref_primary_10_1016_j_ejphar_2013_04_022 crossref_primary_10_1213_ANE_0b013e3182a8fa7b crossref_primary_10_1016_j_jpain_2011_08_003 crossref_primary_10_1093_bja_aet031 crossref_primary_10_1111_j_1365_2125_2010_03844_x crossref_primary_10_1007_s40122_022_00462_1 crossref_primary_10_1310_hpj4311_937 crossref_primary_10_1124_jpet_117_243972 crossref_primary_10_1007_s11695_014_1431_7 crossref_primary_10_1155_2021_1541748 crossref_primary_10_1213_ANE_0b013e3181bd1612 crossref_primary_10_1586_14737175_2013_859524 crossref_primary_10_1590_0100_6991e_20181756 crossref_primary_10_1016_j_jpain_2012_09_005 crossref_primary_10_1016_j_annfar_2009_01_019 crossref_primary_10_1097_EJA_0b013e328344d998 crossref_primary_10_1016_j_annepidem_2010_03_010 crossref_primary_10_1213_ane_0b013e3181813508 crossref_primary_10_1016_j_pbb_2009_09_017 crossref_primary_10_1093_bja_aeq113 crossref_primary_10_1097_EJA_0b013e328347dfd4 crossref_primary_10_1016_j_ejphar_2013_01_005 crossref_primary_10_1124_jpet_118_249359 crossref_primary_10_1097_ACO_0b013e328330373a crossref_primary_10_34172_ahj_2023_1364 crossref_primary_10_1016_j_pain_2010_01_007 |
Cites_doi | 10.1097/00000542-200412000-00023 10.1007/BF02253538 10.1016/0028-3908(86)90198-X 10.1016/0306-4603(86)90052-3 10.1136/bmj.2.5920.656 10.1016/0024-3205(93)90130-U 10.1037/h0034256 10.1213/01.ANE.0000068822.10113.9E 10.1007/BF02246552 10.1016/S0028-3908(00)00139-8 10.1002/bms.1200200503 10.1037/1064-1297.6.1.96 10.1016/S0165-6147(00)01489-9 10.1016/0306-4603(84)90018-2 10.1016/0091-3057(94)90494-4 10.1016/S0024-3205(03)00178-4 10.1007/s002130100770 10.1097/00000542-200512000-00025 10.1021/jm970377o 10.2165/00002018-199818040-00005 10.1124/jpet.106.112649 10.1093/bja/aeh123 10.1037/0022-3514.42.5.946 10.1097/00000542-200206000-00026 10.1053/rapm.2001.25070 10.1111/j.1467-9450.1984.tb01021.x 10.1016/j.atc.2004.11.007 10.1038/19756 10.1016/S0378-4347(00)81033-6 10.1111/j.1399-6576.2004.00495.x 10.1016/S0952-8180(01)00219-7 |
ContentType | Journal Article |
Copyright | 2008 INIST-CNRS |
Copyright_xml | – notice: 2008 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1213/ane.0b013e31816f2616 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 1526-7598 |
EndPage | 1004 |
ExternalDocumentID | 10_1213_ane_0b013e31816f2616 18713920 20606076 |
Genre | Randomized Controlled Trial Journal Article |
GroupedDBID | --- .-D .55 .GJ .XZ .Z2 01R 026 08R 0R~ 1CY 1J1 23M 2WC 3O- 40H 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 71W 77Y 7O~ AAAXR AAGIX AAHPQ AAJCS AAMOA AAMTA AAPBV AAQKA AAQQT AARTV AASOK AAUGY AAWTL AAXQO ABASU ABBUW ABDIG ABKPX ABOCM ABPPZ ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFO ACGFS ACILI ACLED ACWDW ACWRI ACXNZ ADBBV ADFPA ADGGA ADNKB AE3 AE6 AEBDS AEETU AENEX AFDTB AFFNX AFMFG AFUWQ AGINI AHOMT AHRYX AHVBC AHXIK AIJEX AJIOK AJNWD AJNYG AJRGT AKALU AKULP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BAWUL BOYCO BQLVK BS7 C1A C45 CS3 DIK DIWNM DUNZO E.X E3Z EBS EEVPB EJD EX3 F2K F2L F2M F2N F5P FCALG FL- FRP FW0 GNXGY GQDEL GX1 H0~ HZ~ IKREB IKYAY IN~ IPNFZ IQODW J5H JF9 JG8 JK3 JK8 K8S KD2 KMI L-C L7B M18 MZP N4W N9A N~7 N~B N~M O9- OAG OAH OB4 OCUKA ODA ODMTH OHYEH OJAPA OK1 OL1 OLG OLH OLL OLU OLV OLW OLY OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OVOZU OWBYB OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P PONUX R58 RIG RLZ S4R S4S TEORI TR2 TSPGW TWZ V2I VVN W3M W8F WOQ WOW X3V X3W X7M XXN XYM YFH YOC YQJ ZA5 ZFV ZGI ZXP ZZMQN AAAAV AAIQE AASCR AAUEB ABJNI ABVCZ ACXJB ADHPY AFEXH AFSOK AHQNM AINUH CGR CUY CVF ECM EIF ERAAH HLJTE NPM AAYXX AJZMW CITATION 7X8 |
ID | FETCH-LOGICAL-c381t-48eafc9ba62e283de91ffdbc0c8d473b41e519d77db9ff309d74ec358c24336a3 |
ISSN | 0003-2999 |
IngestDate | Sat Aug 17 01:07:54 EDT 2024 Fri Aug 23 03:42:44 EDT 2024 Thu May 23 23:12:40 EDT 2024 Sun Oct 22 16:07:45 EDT 2023 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Keywords | Analgesia Anesthesia Alkaloid Nicotine |
Language | English |
License | CC BY 4.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c381t-48eafc9ba62e283de91ffdbc0c8d473b41e519d77db9ff309d74ec358c24336a3 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
OpenAccessLink | https://doi.org/10.1213/ane.0b013e31816f2616 |
PMID | 18713920 |
PQID | 69449337 |
PQPubID | 23479 |
PageCount | 6 |
ParticipantIDs | proquest_miscellaneous_69449337 crossref_primary_10_1213_ane_0b013e31816f2616 pubmed_primary_18713920 pascalfrancis_primary_20606076 |
PublicationCentury | 2000 |
PublicationDate | 2008-09-01 |
PublicationDateYYYYMMDD | 2008-09-01 |
PublicationDate_xml | – month: 09 year: 2008 text: 2008-09-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | Hagerstown, MD |
PublicationPlace_xml | – name: Hagerstown, MD – name: United States |
PublicationTitle | Anesthesia and analgesia |
PublicationTitleAlternate | Anesth Analg |
PublicationYear | 2008 |
Publisher | Lippincott |
Publisher_xml | – name: Lippincott |
References | Craft (R21-48-20210902) 2003; 72 Damaj (R28-48-20210902) 2000; 39 Pomerleau (R18-48-20210902) 1986; 22 Marubio (R25-48-20210902) 1999; 398 Caggiula (R26-48-20210902) 1995; 122 Jacob (R14-48-20210902) 1991; 20 Silverstein (R17-48-20210902) 1982; 42 Flood (R11-48-20210902) 2004; 101 Habib (R3-48-20210902) 2005; 23 Jamner (R8-48-20210902) 1998; 6 Gan (R2-48-20210902) 2004; 92 Damaj (R7-48-20210902) 1994; 48 Li (R27-48-20210902) 2002; 96 Greenland (R30-48-20210902) 1998; 18 Pauli (R16-48-20210902) 1993; 111 Gan (R32-48-20210902) 2004; 48 Aceto (R4-48-20210902) 1986; 25 Werner (R20-48-20210902) 2001; 26 Apfelbaum (R1-48-20210902) 2003; 97 Jacob (R13-48-20210902) 1981; 222 Block (R5-48-20210902) 1993; 53 Elia (R31-48-20210902) 2005; 103 Carstens (R6-48-20210902) 2001; 157 Holladay (R22-48-20210902) 1997; 40 Pomerleau (R10-48-20210902) 1984; 9 Mueser (R29-48-20210902) 1984; 25 Ramsay (R12-48-20210902) 1974; 2 Cordero-Erausquin (R23-48-20210902) 2000; 21 Damaj (R24-48-20210902) 2007; 321 Fertig (R9-48-20210902) 1986; 11 Huang (R15-48-20210902) 2001; 13 Nesbitt (R19-48-20210902) 1973; 25 |
References_xml | – volume: 101 start-page: 1417 year: 2004 ident: R11-48-20210902 article-title: Intranasal nicotine for postoperative pain treatment. publication-title: Anesthesiology doi: 10.1097/00000542-200412000-00023 contributor: fullname: Flood – volume: 111 start-page: 472 year: 1993 ident: R16-48-20210902 article-title: Effects of smoking on thermal pain threshold in deprived and minimally-deprived habitual smokers. publication-title: Psychopharmacology (Berl) doi: 10.1007/BF02253538 contributor: fullname: Pauli – volume: 25 start-page: 1031 year: 1986 ident: R4-48-20210902 article-title: The spinal cord as a major site for the antinociceptive action of nicotine in the rat. publication-title: Neuropharmacology doi: 10.1016/0028-3908(86)90198-X contributor: fullname: Aceto – volume: 11 start-page: 239 year: 1986 ident: R9-48-20210902 article-title: Nicotine-produced antinociception in minimally deprived smokers and ex-smokers. publication-title: Addict Behav doi: 10.1016/0306-4603(86)90052-3 contributor: fullname: Fertig – volume: 2 start-page: 656 year: 1974 ident: R12-48-20210902 article-title: Controlled sedation with alphaxalone-alphadolone. publication-title: BMJ doi: 10.1136/bmj.2.5920.656 contributor: fullname: Ramsay – volume: 53 start-page: L195 year: 1993 ident: R5-48-20210902 article-title: Nicotine-induced analgesia in rats: the role of calcium and the diversity of responders and nonresponders. publication-title: Life Sci doi: 10.1016/0024-3205(93)90130-U contributor: fullname: Block – volume: 25 start-page: 137 year: 1973 ident: R19-48-20210902 article-title: Smoking, physiological arousal, and emotional response. publication-title: J Pers Soc Psychol doi: 10.1037/h0034256 contributor: fullname: Nesbitt – volume: 97 start-page: 534 year: 2003 ident: R1-48-20210902 article-title: Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. publication-title: Anesth Analg doi: 10.1213/01.ANE.0000068822.10113.9E contributor: fullname: Apfelbaum – volume: 122 start-page: 301 year: 1995 ident: R26-48-20210902 article-title: Different methods of assessing nicotine-induced antinociception may engage different neural mechanisms. publication-title: Psychopharmacology (Berl) doi: 10.1007/BF02246552 contributor: fullname: Caggiula – volume: 39 start-page: 2785 year: 2000 ident: R28-48-20210902 article-title: The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model. publication-title: Neuropharmacology doi: 10.1016/S0028-3908(00)00139-8 contributor: fullname: Damaj – volume: 20 start-page: 247 year: 1991 ident: R14-48-20210902 article-title: Selected ion monitoring method for determination of nicotine, cotinine and deuterium-labeled analogs: absence of an isotope effect in the clearance of (S)-nicotine-3′,3′-d2 in humans. publication-title: Biol Mass Spectrom doi: 10.1002/bms.1200200503 contributor: fullname: Jacob – volume: 6 start-page: 96 year: 1998 ident: R8-48-20210902 article-title: Pain inhibition, nicotine, and gender. publication-title: Exp Clin Psychopharmacol doi: 10.1037/1064-1297.6.1.96 contributor: fullname: Jamner – volume: 21 start-page: 211 year: 2000 ident: R23-48-20210902 article-title: Nicotinic receptor function: new perspectives from knockout mice. publication-title: Trends Pharmacol Sci doi: 10.1016/S0165-6147(00)01489-9 contributor: fullname: Cordero-Erausquin – volume: 9 start-page: 265 year: 1984 ident: R10-48-20210902 article-title: The effects of cigarette smoking on pain and anxiety. publication-title: Addict Behav doi: 10.1016/0306-4603(84)90018-2 contributor: fullname: Pomerleau – volume: 48 start-page: 37 year: 1994 ident: R7-48-20210902 article-title: Nicotine-induced antinociception in mice: role of G-proteins and adenylate cyclase. publication-title: Pharmacol Biochem Behav doi: 10.1016/0091-3057(94)90494-4 contributor: fullname: Damaj – volume: 72 start-page: 2675 year: 2003 ident: R21-48-20210902 article-title: Sex differences in drug- and non-drug-induced analgesia. publication-title: Life Sci doi: 10.1016/S0024-3205(03)00178-4 contributor: fullname: Craft – volume: 157 start-page: 40 year: 2001 ident: R6-48-20210902 article-title: Analgesia induced by chronic nicotine infusion in rats: differences by gender and pain test. publication-title: Psychopharmacology (Berl) doi: 10.1007/s002130100770 contributor: fullname: Carstens – volume: 103 start-page: 1296 year: 2005 ident: R31-48-20210902 article-title: Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. publication-title: Anesthesiology doi: 10.1097/00000542-200512000-00025 contributor: fullname: Elia – volume: 22 start-page: 865 year: 1986 ident: R18-48-20210902 article-title: Nicotine as a psychoactive drug: anxiety and pain reduction. publication-title: Psychopharmacol Bull contributor: fullname: Pomerleau – volume: 40 start-page: 4169 year: 1997 ident: R22-48-20210902 article-title: Neuronal nicotinic acetylcholine receptors as targets for drug discovery. publication-title: J Med Chem doi: 10.1021/jm970377o contributor: fullname: Holladay – volume: 18 start-page: 297 year: 1998 ident: R30-48-20210902 article-title: A meta-analysis to assess the incidence of adverse effects associated with the transdermal nicotine patch. publication-title: Drug Saf doi: 10.2165/00002018-199818040-00005 contributor: fullname: Greenland – volume: 321 start-page: 1161 year: 2007 ident: R24-48-20210902 article-title: Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice. publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.106.112649 contributor: fullname: Damaj – volume: 92 start-page: 681 year: 2004 ident: R2-48-20210902 article-title: Patient preferences for acute pain treatment. publication-title: Br J Anaesth doi: 10.1093/bja/aeh123 contributor: fullname: Gan – volume: 42 start-page: 946 year: 1982 ident: R17-48-20210902 article-title: Cigarette smoking, nicotine addiction, and relaxation. publication-title: J Pers Soc Psychol doi: 10.1037/0022-3514.42.5.946 contributor: fullname: Silverstein – volume: 96 start-page: 1450 year: 2002 ident: R27-48-20210902 article-title: Nicotinic acetylcholine receptor regulation of spinal norepinephrine release. publication-title: Anesthesiology doi: 10.1097/00000542-200206000-00026 contributor: fullname: Li – volume: 26 start-page: 322 year: 2001 ident: R20-48-20210902 article-title: Effects of gabapentin in acute inflammatory pain in humans. publication-title: Regional Anesth Pain Med doi: 10.1053/rapm.2001.25070 contributor: fullname: Werner – volume: 25 start-page: 289 year: 1984 ident: R29-48-20210902 article-title: Smoking and pain–a method of limits and sensory decision theory analysis. publication-title: Scand J Psychol doi: 10.1111/j.1467-9450.1984.tb01021.x contributor: fullname: Mueser – volume: 23 start-page: 85 year: 2005 ident: R3-48-20210902 article-title: Role of analgesic adjuncts in postoperative pain management. publication-title: Anesthesiol Clin North Am doi: 10.1016/j.atc.2004.11.007 contributor: fullname: Habib – volume: 398 start-page: 805 year: 1999 ident: R25-48-20210902 article-title: Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. publication-title: Nature doi: 10.1038/19756 contributor: fullname: Marubio – volume: 222 start-page: 61 year: 1981 ident: R13-48-20210902 article-title: Improved gas chromatographic method for the determination of nicotine and cotinine in biologic fluids. publication-title: J Chromatogr A doi: 10.1016/S0378-4347(00)81033-6 contributor: fullname: Jacob – volume: 48 start-page: 1194 year: 2004 ident: R32-48-20210902 article-title: Presurgical intravenous parecoxib sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid-related adverse effects. publication-title: Acta Anaesthesiol Scand doi: 10.1111/j.1399-6576.2004.00495.x contributor: fullname: Gan – volume: 13 start-page: 94 year: 2001 ident: R15-48-20210902 article-title: Preoperative oral rofecoxib does not decrease postoperative pain or morphine consumption in patients after radical prostatectomy: a prospective, randomized, double-blinded, placebo-controlled trial. publication-title: J Clin Anesth doi: 10.1016/S0952-8180(01)00219-7 contributor: fullname: Huang |
SSID | ssj0001086 |
Score | 2.1563115 |
Snippet | Previous animal and human studies suggested that nicotine might have an antinociceptive effect. We hypothesized that the preoperative application of a 7 mg... BACKGROUNDPrevious animal and human studies suggested that nicotine might have an antinociceptive effect. We hypothesized that the preoperative application of... |
SourceID | proquest crossref pubmed pascalfrancis |
SourceType | Aggregation Database Index Database |
StartPage | 999 |
SubjectTerms | Administration, Cutaneous Aged Analgesia - methods Anesthesia Anesthesia, General - methods Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Double-Blind Method Humans Male Medical sciences Middle Aged Morphine - therapeutic use Nicotine - administration & dosage Nicotine - therapeutic use Nicotinic Agonists - administration & dosage Nicotinic Agonists - therapeutic use Pain, Postoperative - drug therapy Placebos Prospective Studies Prostatectomy - methods |
Title | Transdermal Nicotine for Analgesia After Radical Retropubic Prostatectomy |
URI | https://www.ncbi.nlm.nih.gov/pubmed/18713920 https://search.proquest.com/docview/69449337 |
Volume | 107 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagXJAQAvHaAsUHbpUhiZ2HjxUqW5DKhVbaWzR-hK7Ubleb9MKvZ_xIvAutBFyiKE5sZebTvDzjIeQ9YgS1oJEMrAEmyswwqVTDlLA4UtpK-Aq502_Vybn4uigXKYndV5cM6oP-eWtdyf9wFZ8hX12V7D9wdpoUH-A98hevyGG8_h2PnaIxTrZeHq6QpYMzGUNapGvf0buCK98DfANhO2ZjB9exSy21S8zyxUR6GIsapiOVUVFchI_9Qa5xqiSr1NJv4hz1FxvoUux06rUXYzgpmfj48nAOfejbfAo_zDJFUL-jgvKRnTlcxd8dYxDNlGSFKiTKzaJidRkaSk-CNfSzjQjiW2JShqZIf4jvIuf-3GKb4rN51aGTV22_jkxYX3mW5ujuoYGXJWU2pRiOQ_fJg6KWpfPL54uU_eMaTMVKSlz0421LuvNk4yQ7RsujNfTIsi40PrnbM_EWytkT8ji6FvQo4OQpuWdXz8iXLYzQESMUMUInxlKPERoxQhNG6A5GnpPzz8dnn05YbJ_BNJphAxONhU5LBVVh0Yg0VuZdZ5TOdGNEzZXILZrvpq6Nkl3HM7wVVvOy0YXgvAL-guytrlf2FaG1ApsXqkDfQAsAg06ywHckaMhAGJgRNtKnXYdTUlrnXSJpWyRt-ztpZ-Rgh4jTR0WGDnVW4wvvRqq2KO_cJhbOc33Tt5UUQnJez8jLQOy0YGTW_p0jr8nDhN43ZG_Y3Ni3aFMO6sCj4xfQ1nfI |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Geneva Foundation for Medical Education and Research |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Transdermal+nicotine+for+analgesia+after+radical+retropubic+prostatectomy&rft.jtitle=Anesthesia+and+analgesia&rft.au=Habib%2C+Ashraf+S&rft.au=White%2C+William+D&rft.au=El+Gasim%2C+Magdi+A&rft.au=Saleh%2C+Gamal&rft.date=2008-09-01&rft.eissn=1526-7598&rft.volume=107&rft.issue=3&rft.spage=999&rft_id=info:doi/10.1213%2Fane.0b013e31816f2616&rft_id=info%3Apmid%2F18713920&rft.externalDocID=18713920 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-2999&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-2999&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-2999&client=summon |