Studying signal compartmentation in adult cardiomyocytes

• Published in: Biochemical Society transactions Vol. 48; no. 1; p. 61
• Main Authors: Judina, Aleksandra, Gorelik, Julia, Wright, Peter T
• Format: Journal Article
• Language: English
• Published: England 28.02.2020
• Subjects: Animals; Calcium Signaling; Caveolae - metabolism; Cell Compartmentation - physiology; Cyclic AMP - metabolism; Fluorescence Resonance Energy Transfer - methods; Heart Failure - metabolism; Myocytes, Cardiac - metabolism; Signal Transduction - physiology; compartmentation; t-tubules; calcium; cAMP; cardiovascular; caveolae

Multiple intra-cellular signalling pathways rely on calcium and 3'-5' cyclic adenosine monophosphate (cAMP) to act as secondary messengers. This is especially true in cardiomyocytes which act as the force-producing units of the cardiac muscle and are required to react rapidly to environmen...