Evaluation of local instillation of antibiotics in infected walled-off pancreatic necrosis

• Published in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 18; no. 6; pp. 642 - 646
• Main Authors: Werge, Mikkel, Novovic, Srdan, Roug, Stine, Knudsen, Jenny Dahl, Feldager, Erik, Gluud, Lise Lotte, Schmidt, Palle Nordblad
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 01.09.2018; Elsevier Limited
• Subjects: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Amphotericin B; Amphotericin B - therapeutic use; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antifungal Agents - therapeutic use; Bacterial Infections - drug therapy; Cohort Studies; Drainage; Endoscopy; Etiology; Female; Fungi; Gangrene; Humans; Infection; Intravenous administration; Lavage; Male; Middle Aged; Morbidity; Mortality; Mycoses - drug therapy; Necrosis; Necrotizing pancreatitis; Pancreas; Pancreatic collection; Pancreatitis; Pancreatitis, Acute Necrotizing - drug therapy; Pancreatitis, Acute Necrotizing - microbiology; Pancreatitis, Acute Necrotizing - mortality; Patients; Retrospective Studies; Treatment; Infection; Pancreatic collection; Treatment; Necrotizing pancreatitis

Infected walled-off pancreatic necrosis (WON) is associated with increased morbidity and mortality. Systemic antibiotics are the main treatment, but are associated with adverse reactions and risk of superinfections. This study evaluates the efficacy of local instillation of antibiotics into WON. We...