Tetrahedral framework nucleic acids prevent retina ischemia-reperfusion injury from oxidative stress via activating the Akt/Nrf2 pathway

• Published in: Nanoscale Vol. 11; no. 43; pp. 20667 - 20675
• Main Authors: Qin, Xin, Li, Ni, Zhang, Mei, Lin, Shiyu, Zhu, Junyao, Xiao, Dexuan, Cui, Weitong, Zhang, Tianyi, Lin, Yunfeng, Cai, XiaoXiao
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 21.11.2019
• Subjects: Animals; Antioxidants; Antioxidants - chemistry; Apoptosis; Biocompatibility; Brain damage; Carbocyanines - chemistry; Cell Line; Cell Survival - drug effects; Damage accumulation; Damage prevention; Diabetic retinopathy; DNA, Single-Stranded - chemistry; Eye injuries; Glaucoma; Image transmission; Injury prevention; Ischemia; L-Lactate Dehydrogenase - metabolism; Mice; Microscopy, Fluorescence; Nanomaterials; Nanostructures - chemistry; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacology; NF-E2-Related Factor 2 - metabolism; Nucleic acids; Occlusion; Oxidation; Oxidative stress; Oxidative Stress - drug effects; Proto-Oncogene Proteins c-akt - metabolism; Reactive Oxygen Species - metabolism; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Retinal Ganglion Cells - cytology; Retinal Ganglion Cells - metabolism; Signal Transduction - drug effects; Superoxide Dismutase - metabolism; tert-Butylhydroperoxide - chemistry; tert-Butylhydroperoxide - toxicity; Viability; Visual fields

Retinal ischemia-reperfusion (I/R) injuries are involved in the universal pathological processes of many ophthalmic diseases, including glaucoma, diabetic retinopathy, and retinal arterial occlusion. The reason is that the ischemia-reperfusion injury is accompanied by the abnormal accumulation of re...