Effect of Nitrous Oxide Anesthesia on Plasma Homocysteine and Endothelial Function

• Published in: Anesthesiology (Philadelphia) Vol. 109; no. 4; pp. 657 - 663
• Main Authors: MYLES, Paul S, CHAN, Matthew T. V, KAYE, David M, MCLLROY, David R, LAU, Chung-Wai, SYMONS, Joel A, SHAOHUI CHEN
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.10.2008
• Subjects: Aged; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Inhalation - adverse effects; Arginine - analogs & derivatives; Arginine - blood; Biological and medical sciences; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Female; Homocysteine - blood; Humans; Male; Medical sciences; Middle Aged; Nitrous Oxide - adverse effects; Oxidative Stress; Prospective Studies; Time Factors; Anesthesia

Endothelial function is impaired with hyperhomocysteinemia. Plasma homocysteine is increased by nitrous oxide anesthesia. The current study was designed to determine whether endothelial function is impaired after surgery and whether this is made worse by exposure to nitrous oxide. The authors studie...