A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis

• Published in: Human molecular genetics Vol. 19; no. 3; pp. 553 - 562
• Main Authors: Schaefer, Arne S., Richter, Gesa M., Nothnagel, Michael, Manke, Thomas, Dommisch, Henrik, Jacobs, Gunnar, Arlt, Alexander, Rosenstiel, Philip, Noack, Barbara, Groessner-Schreiber, Birte, Jepsen, Søren, Loos, Bruno G., Schreiber, Stefan
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.02.2010
• Subjects: Adult; Aged; Aggressive Periodontitis - enzymology; Aggressive Periodontitis - genetics; Biological and medical sciences; Case-Control Studies; Cell Line; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Fundamental and applied biological sciences. Psychology; GATA3 Transcription Factor - genetics; GATA3 Transcription Factor - metabolism; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Humans; Male; Medical sciences; Middle Aged; Molecular and cellular biology; Non tumoral diseases; Otorhinolaryngology. Stomatology; Polymorphism, Single Nucleotide; Periodontal disease; Sensitivity; Association; Periodontitis; Stomatology; Susceptibility locus; Genetics; Identification

Periodontitis is a widespread, complex inflammatory disease of the mouth, which results in a loss of gingival tissue and alveolar bone, with aggressive periodontitis (AgP) as its most severe form. To identify genetic risk factors for periodontitis, we conducted a genome-wide association study in Ger...