Differential Reversible and Irreversible Interactions between Benzbromarone and Human Cytochrome P450s 3A4 and 3A5

• Published in: Molecular pharmacology Vol. 100; no. 3; pp. 224 - 236
• Main Authors: Tang, Lloyd Wei Tat, Verma, Ravi Kumar, Yong, Ren Ping, Li, Xin, Wang, Lili, Lin, Qingsong, Fan, Hao, Chan, Eric Chun Yong
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.09.2021
• Subjects: G6P; OBS; Km; BF; LC/MS/MS; MS; G6PDH; RMSD; MUT; PDB; BBR; DBP; MBI; KB; MD; rCYP3A4; rCYP3A5; P450; SASA; WT; PBP

Mounting evidence has revealed that despite the high degree of sequence homology between cytochrome P450 3A isoforms (i.e., CYP3A4 and CYP3A5), they have the propensities to exhibit vastly different irreversible and reversible interactions with a single substrate. We have previously established that...