ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder

• Published in: Medical science monitor Vol. 20; pp. 905 - 912
• Main Authors: Talarowska, Monika, Szemraj, Janusz, Zajączkowska, Marlena, Gałecki, Piotr
• Format: Journal Article
• Language: English
• Published: United States International Scientific Literature, Inc 02.06.2014
• Subjects: Acetylserotonin O-Methyltransferase - genetics; Acetylserotonin O-Methyltransferase - metabolism; Adult; Aged; Clinical Research; Cognition Disorders - complications; Cognition Disorders - enzymology; Cognition Disorders - genetics; Depressive Disorder - complications; Depressive Disorder - enzymology; Depressive Disorder - genetics; Female; Gene Expression Regulation, Enzymologic; Humans; Male; Middle Aged; Neuropsychological Tests; Recurrence; Statistics, Nonparametric; Young Adult

Recurrent depressive disorder is a multifactorial disease; one of the typical features is cognitive impairment. The purpose of this study was analysis of ASMT gene expression both on mRNA and protein levels in patients with recurrent depressive disorder (rDD) and assessment of the relationship betwe...