Contributions of the gut microbiota to Gulf War Illness susceptibility: Findings from a mouse model

• Published in: Life sciences (1973) Vol. 359; p. 123244
• Main Authors: Chaudhari, Diptaraj S., Francescutti, Dina M., Winters, Andrew D., Koka, Orena, Kracht, David J., Greenberg, Jonathan M., Theis, Kevin R., Angoa-Perez, Mariana
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.12.2024
• Subjects: Animals; cognition; community structure; Disease Models, Animal; Disease Susceptibility; emotions; Gastrointestinal Microbiome - drug effects; gastrointestinal system; genes; Gulf War Illness; Gut microbiome; intestinal microorganisms; Kansas; Male; males; metabolites; Metabolomics; Mice; Mice, Inbred C57BL; microbial communities; pain; Persian Gulf Syndrome - metabolism; Persian Gulf Syndrome - microbiology; Pyridostigmine bromide; Pyridostigmine Bromide - pharmacology; RNA, Ribosomal, 16S - genetics; Susceptibility; Kansas; Metabolomics; Gulf War Illness; Susceptibility; Gut microbiome; Pyridostigmine bromide
• ISSN: 0024-3205; 1879-0631; 1879-0631
• DOI: 10.1016/j.lfs.2024.123244

In light of the evidence supporting a significant role of the gut microbiome in Gulf War Illness (GWI) pathology, we sought to examine its contribution to GWI susceptibility in a mouse model. We also aimed to identify bacterial taxa and microbially-derived metabolites associated with disease suscept...