Luteolin-induced coronary arterial relaxation involves activation of the myocyte voltage-gated K+ channels and inward rectifier K+ channels

• Published in: Life sciences (1973) Vol. 221; pp. 233 - 240
• Main Authors: Li, Weiping, Dong, Miaomiao, Guo, Pengmei, Liu, Yu, Jing, Yixin, Chen, Rui, Zhang, Mingsheng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.03.2019; Elsevier BV
• Subjects: Animals; Arginine; Arteries; Barium chloride; Calcium; Calcium (extracellular); Calcium Channel Blockers; Calcium ions; Channels; Coronary artery; Coronary Vessels - drug effects; Depolarization; Endothelium; Food additives; Indomethacin; Inhibitors; Inward rectifier potassium channel; Luteolin; Luteolin - pharmacology; Male; Muscle Cells; Muscle, Smooth, Vascular - metabolism; Muscles; Myocytes, Smooth Muscle - physiology; NG-Nitroarginine methyl ester; Nitric oxide; Organs; Potassium; Potassium - metabolism; Potassium Channel Blockers - metabolism; Potassium channels; Potassium channels (inwardly-rectifying); Potassium channels (voltage-gated); Potassium Channels, Inwardly Rectifying - drug effects; Potassium Channels, Voltage-Gated - drug effects; Potassium chloride; Potassium currents; Prostaglandin endoperoxide synthase; Rats; Rats, Wistar; Rectifiers; Smooth muscle; Thromboxane A2; Vascular Stiffness - drug effects; Vasoconstriction; Vasoconstrictors; Vasodilation; Vasopressin; Vasorelaxation; Voltage-gated potassium channel; Luteolin; Voltage-gated potassium channel; Vasorelaxation; Inward rectifier potassium channel; Coronary artery

Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K+ currents via voltage-gated potassium (Kv) channels and...