eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells

Increasing studies have revealed that a subset of circular RNAs (circRNAs) harbor an open reading frame and can act as protein-coding templates to generate functional proteins that are closely associated with multiple physiological and disease-relevant processes, and thus proper regulation of synthe...

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Published inNucleic acids research Vol. 50; no. 20; pp. 11529 - 11549
Main Authors Song, Zhenxing, Lin, Jiamei, Su, Rui, Ji, Yu, Jia, Ruirui, Li, Shi, Shan, Ge, Huang, Chuan
Format Journal Article
LanguageEnglish
Published England Oxford University Press 11.11.2022
Subjects
Animals
Cytoplasm - metabolism
Drosophila
Drosophila Proteins - metabolism
Eukaryotic Initiation Factor-3 - metabolism
Gene regulation, Chromatin and Epigenetics
Protein Biosynthesis
RNA, Circular - genetics
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Abstract Increasing studies have revealed that a subset of circular RNAs (circRNAs) harbor an open reading frame and can act as protein-coding templates to generate functional proteins that are closely associated with multiple physiological and disease-relevant processes, and thus proper regulation of synthesis of these circRNA-derived proteins is a fundamental cellular process required for homeostasis maintenance. However, how circRNA translation initiation is coordinated by different trans-acting factors remains poorly understood. In particular, the impact of different eukaryotic translation initiation factors (eIFs) on circRNA translation and the physiological relevance of this distinct regulation have not yet been characterized. In this study, we screened all 43 Drosophila eIFs and revealed the conflicting functions of eIF3 subunits in the translational control of the translatable circRNA circSfl: eIF3 is indispensable for circSfl translation, while the eIF3-associated factor eIF3j is the most potent inhibitor. Mechanistically, the binding of eIF3j to circSfl promotes the disassociation of eIF3. The C-terminus of eIF3j and an RNA regulon within the circSfl untranslated region (UTR) are essential for the inhibitory effect of eIF3j. Moreover, we revealed the physiological relevance of eIF3j-mediated circSfl translation repression in response to heat shock. Finally, additional translatable circRNAs were identified to be similarly regulated in an eIF3j-dependent manner. Altogether, our study provides a significant insight into the field of cap-independent translational regulation and undiscovered functions of eIF3.
AbstractList Increasing studies have revealed that a subset of circular RNAs (circRNAs) harbor an open reading frame and can act as protein-coding templates to generate functional proteins that are closely associated with multiple physiological and disease-relevant processes, and thus proper regulation of synthesis of these circRNA-derived proteins is a fundamental cellular process required for homeostasis maintenance. However, how circRNA translation initiation is coordinated by different trans-acting factors remains poorly understood. In particular, the impact of different eukaryotic translation initiation factors (eIFs) on circRNA translation and the physiological relevance of this distinct regulation have not yet been characterized. In this study, we screened all 43 Drosophila eIFs and revealed the conflicting functions of eIF3 subunits in the translational control of the translatable circRNA circSfl: eIF3 is indispensable for circSfl translation, while the eIF3-associated factor eIF3j is the most potent inhibitor. Mechanistically, the binding of eIF3j to circSfl promotes the disassociation of eIF3. The C-terminus of eIF3j and an RNA regulon within the circSfl untranslated region (UTR) are essential for the inhibitory effect of eIF3j. Moreover, we revealed the physiological relevance of eIF3j-mediated circSfl translation repression in response to heat shock. Finally, additional translatable circRNAs were identified to be similarly regulated in an eIF3j-dependent manner. Altogether, our study provides a significant insight into the field of cap-independent translational regulation and undiscovered functions of eIF3.
Abstract Increasing studies have revealed that a subset of circular RNAs (circRNAs) harbor an open reading frame and can act as protein-coding templates to generate functional proteins that are closely associated with multiple physiological and disease-relevant processes, and thus proper regulation of synthesis of these circRNA-derived proteins is a fundamental cellular process required for homeostasis maintenance. However, how circRNA translation initiation is coordinated by different trans-acting factors remains poorly understood. In particular, the impact of different eukaryotic translation initiation factors (eIFs) on circRNA translation and the physiological relevance of this distinct regulation have not yet been characterized. In this study, we screened all 43 Drosophila eIFs and revealed the conflicting functions of eIF3 subunits in the translational control of the translatable circRNA circSfl: eIF3 is indispensable for circSfl translation, while the eIF3-associated factor eIF3j is the most potent inhibitor. Mechanistically, the binding of eIF3j to circSfl promotes the disassociation of eIF3. The C-terminus of eIF3j and an RNA regulon within the circSfl untranslated region (UTR) are essential for the inhibitory effect of eIF3j. Moreover, we revealed the physiological relevance of eIF3j-mediated circSfl translation repression in response to heat shock. Finally, additional translatable circRNAs were identified to be similarly regulated in an eIF3j-dependent manner. Altogether, our study provides a significant insight into the field of cap-independent translational regulation and undiscovered functions of eIF3.
Increasing studies have revealed that a subset of circular RNAs (circRNAs) harbor an open reading frame and can act as protein-coding templates to generate functional proteins that are closely associated with multiple physiological and disease-relevant processes, and thus proper regulation of synthesis of these circRNA-derived proteins is a fundamental cellular process required for homeostasis maintenance. However, how circRNA translation initiation is coordinated by different trans -acting factors remains poorly understood. In particular, the impact of different eukaryotic translation initiation factors (eIFs) on circRNA translation and the physiological relevance of this distinct regulation have not yet been characterized. In this study, we screened all 43 Drosophila eIFs and revealed the conflicting functions of eIF3 subunits in the translational control of the translatable circRNA circSfl : eIF3 is indispensable for circSfl translation, while the eIF3-associated factor eIF3j is the most potent inhibitor. Mechanistically, the binding of eIF3j to circSfl promotes the disassociation of eIF3. The C-terminus of eIF3j and an RNA regulon within the circSfl untranslated region (UTR) are essential for the inhibitory effect of eIF3j. Moreover, we revealed the physiological relevance of eIF3j-mediated circSfl translation repression in response to heat shock. Finally, additional translatable circRNAs were identified to be similarly regulated in an eIF3j-dependent manner. Altogether, our study provides a significant insight into the field of cap-independent translational regulation and undiscovered functions of eIF3.
Author Li, Shi
Huang, Chuan
Jia, Ruirui
Shan, Ge
Lin, Jiamei
Su, Rui
Song, Zhenxing
Ji, Yu
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Cites_doi 10.1080/15476286.2017.1391437
10.1038/s41421-019-0113-y
10.1186/s12943-020-01246-x
10.1074/jbc.M114.602870
10.1093/nar/gkn188
10.1038/s41467-018-06862-2
10.1093/emboj/20.4.891
10.1007/s11427-020-1743-8
10.1093/nar/gkt1369
10.1016/j.molcel.2021.07.042
10.1038/nrm2255
10.1002/wrna.1723
10.1016/j.molcel.2014.08.019
10.1016/j.tibs.2021.11.004
10.1080/15476286.2020.1766179
10.1371/journal.pgen.1006326
10.1073/pnas.0801313105
10.1002/advs.202001701
10.1093/jmcb/mjaa018
10.1016/j.tibs.2017.03.004
10.1186/s13059-020-02250-6
10.3389/fonc.2015.00264
10.1101/gad.251926.114
10.1093/emboj/20.11.2954
10.1038/nsmb.1838
10.1016/S0021-9258(17)40805-2
10.1038/s41467-022-31327-y
10.1146/annurev-biochem-060713-035802
10.1186/s12943-018-0911-0
10.1016/j.molcel.2017.02.017
10.1038/nsmb.1445
10.1016/j.molcel.2017.10.034
10.1038/emboj.2008.49
10.1038/nmeth.1611
10.1038/sj.onc.1203601
10.1038/s41467-018-05096-6
10.1523/JNEUROSCI.0299-19.2019
10.1038/nsmb.2959
10.1016/j.tcb.2019.12.004
10.1016/j.tibs.2020.08.006
10.1038/nrm.2017.103
10.1186/s12943-020-1135-7
10.1016/j.molcel.2013.08.017
10.1074/jbc.M109.029462
10.1093/nar/gkz1185
10.1038/s41467-019-12651-2
10.1016/j.celrep.2020.108534
10.1038/celldisc.2015.29
10.1016/j.jmb.2009.12.047
10.1038/nplants.2017.53
10.1038/s41421-021-00297-8
10.1261/rna.052944.115
10.1080/15476286.2020.1853977
10.1093/nar/gkaa823
10.4093/dmj.2014.38.2.100
10.1093/nar/gkw1117
10.1038/s41467-022-33356-z
10.1016/j.molcel.2016.05.033
10.1101/gad.1255704
10.1101/gad.1957510
10.1038/cr.2017.31
10.1007/s12094-020-02371-1
10.1038/nature18954
10.1080/10409238.2016.1276882
10.1093/nar/gkab474
10.1101/gad.305250.117
10.1101/gad.314856.118
10.1074/jbc.M312745200
10.7554/eLife.48193
10.1016/j.celrep.2014.10.062
10.1186/s12943-020-01183-9
10.1126/sciadv.abc0221
10.1093/emboj/cdf563
10.1016/j.molcel.2007.05.019
10.1038/nature14891
10.1016/j.cell.2014.09.001
10.1093/nar/gkac684
10.1002/wrna.1685
10.1261/rna.5230104
10.1080/19336934.2016.1220464
10.1038/nsmb.2963
10.1016/j.molcel.2020.06.011
10.1016/j.trecan.2020.01.012
10.1038/s41580-020-0243-y
10.1093/nar/gkw972
10.1038/nature14267
10.1101/gad.270421.115
10.1038/s41419-021-04339-7
10.1111/imr.12240
10.1016/j.molcel.2017.02.021
10.1038/nature14010
10.1080/15384047.2017.1345383
10.1126/sciadv.abb7426
10.1038/s41556-021-00639-4
10.1038/s41576-019-0158-7
10.1242/jcs.041236
10.1074/jbc.M110.119693
10.1093/nar/gkx805
10.1186/1748-7188-6-26
10.1128/MCB.00663-14
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References Cattie (2022120608445782700_B87) 2016; 12
Gruber (2022120608445782700_B77) 2008; 36
Aylett (2022120608445782700_B85) 2015; 22
Gomes-Duarte (2022120608445782700_B36) 2018; 15
Zhou (2022120608445782700_B66) 2008; 105
Chen (2022120608445782700_B15) 2022; 13
Simonetti (2022120608445782700_B63) 2016; 63
Benne (2022120608445782700_B83) 1978; 253
Chen (2022120608445782700_B24) 2019; 10
Hinnebusch (2022120608445782700_B53) 2017; 42
Li (2022120608445782700_B17) 2020; 6
Kwon (2022120608445782700_B89) 2017; 45
Wolf (2022120608445782700_B38) 2020; 12
Leppek (2022120608445782700_B75) 2018; 19
Chen (2022120608445782700_B20) 2022
Li (2022120608445782700_B82) 2021; 8
Unbehaun (2022120608445782700_B84) 2004; 18
Hinnebusch (2022120608445782700_B52) 2014; 83
Wesselhoeft (2022120608445782700_B98) 2018; 9
Konig (2022120608445782700_B48) 2010; 17
Kearse (2022120608445782700_B54) 2017; 31
Wang (2022120608445782700_B93) 2018; 17
Gao (2022120608445782700_B35) 2021; 23
Carmody (2022120608445782700_B13) 2009; 122
Chen (2022120608445782700_B16) 2022; 47
Wagner (2022120608445782700_B59) 2016; 44
Lu (2022120608445782700_B8) 2015; 21
Liang (2022120608445782700_B10) 2017; 68
Westholm (2022120608445782700_B79) 2014; 9
Lorenz (2022120608445782700_B78) 2011; 6
Pamudurti (2022120608445782700_B28) 2017; 66
Valasek (2022120608445782700_B60) 2002; 21
Sehgal (2022120608445782700_B76) 2000; 19
Fraser (2022120608445782700_B73) 2004; 279
Li (2022120608445782700_B5) 2015; 22
Shi (2022120608445782700_B33) 2020; 22
Feng (2022120608445782700_B92) 2021; 12
Fischer (2022120608445782700_B19) 2017; 52
Borden (2022120608445782700_B51) 2020; 17
Wu (2022120608445782700_B81) 2021; 22
Song (2022120608445782700_B45) 2021; 64
Legnini (2022120608445782700_B27) 2017; 66
Bronisz (2022120608445782700_B22) 2020; 6
Conn (2022120608445782700_B23) 2017; 3
Huang (2022120608445782700_B30) 2021; 49
Zhang (2022120608445782700_B7) 2018; 9
Yan (2022120608445782700_B18) 2020; 45
Osborne (2022120608445782700_B96) 2015; 263
Dmitriev (2022120608445782700_B91) 2010; 285
Chen (2022120608445782700_B1) 2020; 21
Phan (2022120608445782700_B62) 2001; 20
Lee (2022120608445782700_B39) 2015; 522
Fan (2022120608445782700_B100) 2022; 13
Kohler (2022120608445782700_B14) 2007; 8
Pulos-Holmes (2022120608445782700_B40) 2019; 8
Zhang (2022120608445782700_B12) 2014; 159
Pestova (2022120608445782700_B57) 2008; 27
Bellucci (2022120608445782700_B71) 2011; 8
Herrmannova (2022120608445782700_B88) 2020; 48
Sokabe (2022120608445782700_B86) 2014; 289
Terenin (2022120608445782700_B56) 2008; 15
Holcik (2022120608445782700_B58) 2015; 5
Ashwal-Fluss (2022120608445782700_B9) 2014; 56
des Georges (2022120608445782700_B65) 2015; 525
Kristensen (2022120608445782700_B2) 2019; 20
Bochler (2022120608445782700_B64) 2020; 33
You (2022120608445782700_B47) 2021; 7
Kondo (2022120608445782700_B80) 2014; 38
Wagner (2022120608445782700_B67) 2014; 34
Weigelt (2022120608445782700_B34) 2020; 79
Xue (2022120608445782700_B74) 2015; 517
Huang (2022120608445782700_B49) 2015; 1
Zheng (2022120608445782700_B94) 2020; 19
Chen (2022120608445782700_B99) 2021; 81
Jia (2022120608445782700_B44) 2021; 49
Xiao (2022120608445782700_B3) 2020; 30
Jia (2022120608445782700_B46) 2019; 5
Zhou (2022120608445782700_B4) 2021; 18
Yang (2022120608445782700_B29) 2017; 27
Allam (2022120608445782700_B55) 2010; 285
Khoshnevis (2022120608445782700_B61) 2014; 42
Liang (2022120608445782700_B11) 2014; 28
Fraser (2022120608445782700_B69) 2007; 26
Xu (2022120608445782700_B26) 2020; 19
Marygold (2022120608445782700_B50) 2017; 11
Valasek (2022120608445782700_B37) 2017; 45
Elantak (2022120608445782700_B72) 2010; 396
Huang (2022120608445782700_B43) 2018; 32
Skabkin (2022120608445782700_B90) 2010; 24
Lee (2022120608445782700_B41) 2016; 536
Chan (2022120608445782700_B97) 2004; 10
Lei (2022120608445782700_B31) 2020; 19
Jia (2022120608445782700_B70) 2022; 50
Kramer (2022120608445782700_B42) 2015; 29
Valasek (2022120608445782700_B68) 2001; 20
Sinha (2022120608445782700_B32) 2021; 13
Zhang (2022120608445782700_B6) 2013; 51
Gao (2022120608445782700_B21) 2020; 6
Wu (2022120608445782700_B25) 2019; 39
Salton (2022120608445782700_B95) 2017; 18
References_xml – volume: 15
  start-page: 26
  year: 2018
  ident: 2022120608445782700_B36
  article-title: eIF3: a factor for human health and disease
  publication-title: RNA Biol
  doi: 10.1080/15476286.2017.1391437
  contributor:
    fullname: Gomes-Duarte
– volume: 5
  start-page: 45
  year: 2019
  ident: 2022120608445782700_B46
  article-title: Defining an evolutionarily conserved role of GW182 in circular RNA degradation
  publication-title: Cell Discov.
  doi: 10.1038/s41421-019-0113-y
  contributor:
    fullname: Jia
– volume: 19
  start-page: 128
  year: 2020
  ident: 2022120608445782700_B26
  article-title: CircRNA inhibits DNA damage repair by interacting with host gene
  publication-title: Mol. Cancer
  doi: 10.1186/s12943-020-01246-x
  contributor:
    fullname: Xu
– volume: 289
  start-page: 31827
  year: 2014
  ident: 2022120608445782700_B86
  article-title: Human eukaryotic initiation factor 2 (eIF2)-GTP-Met-tRNAi ternary complex and eIF3 stabilize the 43 s preinitiation complex
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.602870
  contributor:
    fullname: Sokabe
– volume: 36
  start-page: W70
  year: 2008
  ident: 2022120608445782700_B77
  article-title: The vienna RNA websuite
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkn188
  contributor:
    fullname: Gruber
– volume: 9
  start-page: 4475
  year: 2018
  ident: 2022120608445782700_B7
  article-title: A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-06862-2
  contributor:
    fullname: Zhang
– volume: 20
  start-page: 891
  year: 2001
  ident: 2022120608445782700_B68
  article-title: Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding
  publication-title: EMBO J.
  doi: 10.1093/emboj/20.4.891
  contributor:
    fullname: Valasek
– volume: 64
  start-page: 784
  year: 2021
  ident: 2022120608445782700_B45
  article-title: Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus
  publication-title: Sci. China Life Sci.
  doi: 10.1007/s11427-020-1743-8
  contributor:
    fullname: Song
– volume: 42
  start-page: 4123
  year: 2014
  ident: 2022120608445782700_B61
  article-title: Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt1369
  contributor:
    fullname: Khoshnevis
– volume: 81
  start-page: 4300
  year: 2021
  ident: 2022120608445782700_B99
  article-title: Structured elements drive extensive circular RNA translation
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2021.07.042
  contributor:
    fullname: Chen
– volume: 8
  start-page: 761
  year: 2007
  ident: 2022120608445782700_B14
  article-title: Exporting RNA from the nucleus to the cytoplasm
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2255
  contributor:
    fullname: Kohler
– start-page: e1723
  year: 2022
  ident: 2022120608445782700_B20
  article-title: Circular RNA in disease: basic properties and biomedical relevance
  publication-title: Wiley Interdiscip. Rev. RNA
  doi: 10.1002/wrna.1723
  contributor:
    fullname: Chen
– volume: 56
  start-page: 55
  year: 2014
  ident: 2022120608445782700_B9
  article-title: circRNA biogenesis competes with pre-mRNA splicing
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2014.08.019
  contributor:
    fullname: Ashwal-Fluss
– volume: 47
  start-page: 250
  year: 2022
  ident: 2022120608445782700_B16
  article-title: Circular RNAs in physiology and non-immunological diseases
  publication-title: Trends Biochem. Sci
  doi: 10.1016/j.tibs.2021.11.004
  contributor:
    fullname: Chen
– volume: 17
  start-page: 1239
  year: 2020
  ident: 2022120608445782700_B51
  article-title: The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery
  publication-title: RNA Biol.
  doi: 10.1080/15476286.2020.1766179
  contributor:
    fullname: Borden
– volume: 12
  start-page: e1006326
  year: 2016
  ident: 2022120608445782700_B87
  article-title: Mutations in nonessential eIF3k and eIF3l genes confer lifespan extension and enhanced resistance to ER stress in caenorhabditis elegans
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1006326
  contributor:
    fullname: Cattie
– volume: 105
  start-page: 18139
  year: 2008
  ident: 2022120608445782700_B66
  article-title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.0801313105
  contributor:
    fullname: Zhou
– volume: 8
  start-page: 2001701
  year: 2021
  ident: 2022120608445782700_B82
  article-title: HNRNPL circularizes ARHGAP35 to produce an oncogenic protein
  publication-title: Adv. Sci. (Weinh)
  doi: 10.1002/advs.202001701
  contributor:
    fullname: Li
– volume: 12
  start-page: 403
  year: 2020
  ident: 2022120608445782700_B38
  article-title: eIF-Three to Tango: emerging functions of translation initiation factor eIF3 in protein synthesis and disease
  publication-title: J. Mol. Cell Biol.
  doi: 10.1093/jmcb/mjaa018
  contributor:
    fullname: Wolf
– volume: 42
  start-page: 589
  year: 2017
  ident: 2022120608445782700_B53
  article-title: Structural insights into the mechanism of scanning and start codon recognition in eukaryotic translation initiation
  publication-title: Trends Biochem. Sci
  doi: 10.1016/j.tibs.2017.03.004
  contributor:
    fullname: Hinnebusch
– volume: 22
  start-page: 33
  year: 2021
  ident: 2022120608445782700_B81
  article-title: A novel protein encoded by circular SMO RNA is essential for hedgehog signaling activation and glioblastoma tumorigenicity
  publication-title: Genome Biol.
  doi: 10.1186/s13059-020-02250-6
  contributor:
    fullname: Wu
– volume: 5
  start-page: 264
  year: 2015
  ident: 2022120608445782700_B58
  article-title: Could the eIF2alpha-Independent translation be the achilles heel of cancer?
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2015.00264
  contributor:
    fullname: Holcik
– volume: 28
  start-page: 2233
  year: 2014
  ident: 2022120608445782700_B11
  article-title: Short intronic repeat sequences facilitate circular RNA production
  publication-title: Genes Dev.
  doi: 10.1101/gad.251926.114
  contributor:
    fullname: Liang
– volume: 20
  start-page: 2954
  year: 2001
  ident: 2022120608445782700_B62
  article-title: A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met
  publication-title: EMBO J.
  doi: 10.1093/emboj/20.11.2954
  contributor:
    fullname: Phan
– volume: 17
  start-page: 909
  year: 2010
  ident: 2022120608445782700_B48
  article-title: iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1838
  contributor:
    fullname: Konig
– volume: 253
  start-page: 3078
  year: 1978
  ident: 2022120608445782700_B83
  article-title: The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)40805-2
  contributor:
    fullname: Benne
– volume: 13
  start-page: 3751
  year: 2022
  ident: 2022120608445782700_B100
  article-title: Pervasive translation of circular RNAs driven by short IRES-like elements
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-31327-y
  contributor:
    fullname: Fan
– volume: 83
  start-page: 779
  year: 2014
  ident: 2022120608445782700_B52
  article-title: The scanning mechanism of eukaryotic translation initiation
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev-biochem-060713-035802
  contributor:
    fullname: Hinnebusch
– volume: 17
  start-page: 166
  year: 2018
  ident: 2022120608445782700_B93
  article-title: EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis
  publication-title: Mol. Cancer
  doi: 10.1186/s12943-018-0911-0
  contributor:
    fullname: Wang
– volume: 66
  start-page: 22
  year: 2017
  ident: 2022120608445782700_B27
  article-title: Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.02.017
  contributor:
    fullname: Legnini
– volume: 15
  start-page: 836
  year: 2008
  ident: 2022120608445782700_B56
  article-title: Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1445
  contributor:
    fullname: Terenin
– volume: 68
  start-page: 940
  year: 2017
  ident: 2022120608445782700_B10
  article-title: The output of protein-coding genes shifts to circular RNAs when the Pre-mRNA processing machinery is limiting
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.10.034
  contributor:
    fullname: Liang
– volume: 27
  start-page: 1060
  year: 2008
  ident: 2022120608445782700_B57
  article-title: eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain iI
  publication-title: EMBO J.
  doi: 10.1038/emboj.2008.49
  contributor:
    fullname: Pestova
– volume: 8
  start-page: 444
  year: 2011
  ident: 2022120608445782700_B71
  article-title: Predicting protein associations with long noncoding RNAs
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1611
  contributor:
    fullname: Bellucci
– volume: 19
  start-page: 2836
  year: 2000
  ident: 2022120608445782700_B76
  article-title: The chicken c-Jun 5' untranslated region directs translation by internal initiation
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1203601
  contributor:
    fullname: Sehgal
– volume: 9
  start-page: 2629
  year: 2018
  ident: 2022120608445782700_B98
  article-title: Engineering circular RNA for potent and stable translation in eukaryotic cells
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05096-6
  contributor:
    fullname: Wesselhoeft
– volume: 39
  start-page: 7369
  year: 2019
  ident: 2022120608445782700_B25
  article-title: Circular RNA TLK1 aggravates neuronal injury and neurological deficits after ischemic stroke via miR-335-3p/TIPARP
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0299-19.2019
  contributor:
    fullname: Wu
– volume: 22
  start-page: 256
  year: 2015
  ident: 2022120608445782700_B5
  article-title: Exon-intron circular RNAs regulate transcription in the nucleus
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2959
  contributor:
    fullname: Li
– volume: 30
  start-page: 226
  year: 2020
  ident: 2022120608445782700_B3
  article-title: Biogenesis and functions of circular RNAs come into focus
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2019.12.004
  contributor:
    fullname: Xiao
– volume: 45
  start-page: 1022
  year: 2020
  ident: 2022120608445782700_B18
  article-title: Circular RNAs in immune response and viral infection
  publication-title: Trends Biochem. Sci
  doi: 10.1016/j.tibs.2020.08.006
  contributor:
    fullname: Yan
– volume: 19
  start-page: 158
  year: 2018
  ident: 2022120608445782700_B75
  article-title: Functional 5' UTR mRNA structures in eukaryotic translation regulation and how to find them
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm.2017.103
  contributor:
    fullname: Leppek
– volume: 19
  start-page: 30
  year: 2020
  ident: 2022120608445782700_B31
  article-title: Translation and functional roles of circular RNAs in human cancer
  publication-title: Mol. Cancer
  doi: 10.1186/s12943-020-1135-7
  contributor:
    fullname: Lei
– volume: 51
  start-page: 792
  year: 2013
  ident: 2022120608445782700_B6
  article-title: Circular intronic long noncoding RNAs
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2013.08.017
  contributor:
    fullname: Zhang
– volume: 285
  start-page: 5713
  year: 2010
  ident: 2022120608445782700_B55
  article-title: Initiation factor eIF2-independent mode of c-Src mRNA translation occurs via an internal ribosome entry site
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.029462
  contributor:
    fullname: Allam
– volume: 48
  start-page: 1969
  year: 2020
  ident: 2022120608445782700_B88
  article-title: Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively
  publication-title: Nucleic. Acids. Res.
  doi: 10.1093/nar/gkz1185
  contributor:
    fullname: Herrmannova
– volume: 10
  start-page: 4695
  year: 2019
  ident: 2022120608445782700_B24
  article-title: N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12651-2
  contributor:
    fullname: Chen
– volume: 33
  start-page: 108534
  year: 2020
  ident: 2022120608445782700_B64
  article-title: Structural differences in translation initiation between pathogenic trypanosomatids and their mammalian hosts
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.108534
  contributor:
    fullname: Bochler
– volume: 1
  start-page: 15029
  year: 2015
  ident: 2022120608445782700_B49
  article-title: RNAi pathway participates in chromosome segregation in mammalian cells
  publication-title: Cell Discov.
  doi: 10.1038/celldisc.2015.29
  contributor:
    fullname: Huang
– volume: 396
  start-page: 1097
  year: 2010
  ident: 2022120608445782700_B72
  article-title: The indispensable N-terminal half of eIF3j/HCR1 cooperates with its structurally conserved binding partner eIF3b/PRT1-RRM and with eIF1A in stringent AUG selection
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2009.12.047
  contributor:
    fullname: Elantak
– volume: 3
  start-page: 17053
  year: 2017
  ident: 2022120608445782700_B23
  article-title: A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation
  publication-title: Nat Plants
  doi: 10.1038/nplants.2017.53
  contributor:
    fullname: Conn
– volume: 7
  start-page: 79
  year: 2021
  ident: 2022120608445782700_B47
  article-title: RNAi-directed knockdown induces nascent transcript degradation and premature transcription termination in the nucleus
  publication-title: Cell Discov.
  doi: 10.1038/s41421-021-00297-8
  contributor:
    fullname: You
– volume: 21
  start-page: 1554
  year: 2015
  ident: 2022120608445782700_B8
  article-title: Metazoan tRNA introns generate stable circular RNAs in vivo
  publication-title: RNA
  doi: 10.1261/rna.052944.115
  contributor:
    fullname: Lu
– volume: 18
  start-page: 1365
  year: 2021
  ident: 2022120608445782700_B4
  article-title: New progresses of circular RNA biology: from nuclear export to degradation
  publication-title: RNA Biol
  doi: 10.1080/15476286.2020.1853977
  contributor:
    fullname: Zhou
– volume: 49
  start-page: D236
  year: 2021
  ident: 2022120608445782700_B30
  article-title: TransCirc: an interactive database for translatable circular RNAs based on multi-omics evidence
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa823
  contributor:
    fullname: Huang
– volume: 38
  start-page: 100
  year: 2014
  ident: 2022120608445782700_B80
  article-title: The role of heat shock response in insulin resistance and diabetes
  publication-title: Diabetes Metab J
  doi: 10.4093/dmj.2014.38.2.100
  contributor:
    fullname: Kondo
– volume: 45
  start-page: 296
  year: 2017
  ident: 2022120608445782700_B89
  article-title: An mRNA-specific tRNAi carrier eIF2A plays a pivotal role in cell proliferation under stress conditions: stress-resistant translation of c-Src mRNA is mediated by eIF2A
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw1117
  contributor:
    fullname: Kwon
– volume: 13
  start-page: 5769
  year: 2022
  ident: 2022120608445782700_B15
  article-title: Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-33356-z
  contributor:
    fullname: Chen
– volume: 63
  start-page: 206
  year: 2016
  ident: 2022120608445782700_B63
  article-title: eIF3 peripheral subunits rearrangement after mRNA binding and start-codon recognition
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2016.05.033
  contributor:
    fullname: Simonetti
– volume: 18
  start-page: 3078
  year: 2004
  ident: 2022120608445782700_B84
  article-title: Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP
  publication-title: Genes Dev.
  doi: 10.1101/gad.1255704
  contributor:
    fullname: Unbehaun
– volume: 24
  start-page: 1787
  year: 2010
  ident: 2022120608445782700_B90
  article-title: Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling
  publication-title: Genes Dev.
  doi: 10.1101/gad.1957510
  contributor:
    fullname: Skabkin
– volume: 27
  start-page: 626
  year: 2017
  ident: 2022120608445782700_B29
  article-title: Extensive translation of circular RNAs driven by N(6)-methyladenosine
  publication-title: Cell Res.
  doi: 10.1038/cr.2017.31
  contributor:
    fullname: Yang
– volume: 22
  start-page: 2162
  year: 2020
  ident: 2022120608445782700_B33
  article-title: The new function of circRNA: translation
  publication-title: Clin. Transl. Oncol.
  doi: 10.1007/s12094-020-02371-1
  contributor:
    fullname: Shi
– volume: 536
  start-page: 96
  year: 2016
  ident: 2022120608445782700_B41
  article-title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
  publication-title: Nature
  doi: 10.1038/nature18954
  contributor:
    fullname: Lee
– volume: 52
  start-page: 220
  year: 2017
  ident: 2022120608445782700_B19
  article-title: CircRNAs: a regulator of cellular stress
  publication-title: Crit. Rev. Biochem. Mol. Biol.
  doi: 10.1080/10409238.2016.1276882
  contributor:
    fullname: Fischer
– volume: 49
  start-page: 6296
  year: 2021
  ident: 2022120608445782700_B44
  article-title: Gawky modulates MTF-1-mediated transcription activation and metal discrimination
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkab474
  contributor:
    fullname: Jia
– volume: 31
  start-page: 1717
  year: 2017
  ident: 2022120608445782700_B54
  article-title: Non-AUG translation: a new start for protein synthesis in eukaryotes
  publication-title: Genes Dev.
  doi: 10.1101/gad.305250.117
  contributor:
    fullname: Kearse
– volume: 32
  start-page: 639
  year: 2018
  ident: 2022120608445782700_B43
  article-title: A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs
  publication-title: Genes Dev.
  doi: 10.1101/gad.314856.118
  contributor:
    fullname: Huang
– volume: 279
  start-page: 8946
  year: 2004
  ident: 2022120608445782700_B73
  article-title: The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M312745200
  contributor:
    fullname: Fraser
– volume: 8
  start-page: e48193
  year: 2019
  ident: 2022120608445782700_B40
  article-title: Repression of ferritin light chain translation by human eIF3
  publication-title: Elife
  doi: 10.7554/eLife.48193
  contributor:
    fullname: Pulos-Holmes
– volume: 9
  start-page: 1966
  year: 2014
  ident: 2022120608445782700_B79
  article-title: Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.10.062
  contributor:
    fullname: Westholm
– volume: 19
  start-page: 73
  year: 2020
  ident: 2022120608445782700_B94
  article-title: The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer
  publication-title: Mol. Cancer
  doi: 10.1186/s12943-020-01183-9
  contributor:
    fullname: Zheng
– volume: 6
  start-page: eabc0221
  year: 2020
  ident: 2022120608445782700_B22
  article-title: The nuclear DICER-circular RNA complex drives the deregulation of the glioblastoma cell microRNAome
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abc0221
  contributor:
    fullname: Bronisz
– volume: 21
  start-page: 5886
  year: 2002
  ident: 2022120608445782700_B60
  article-title: Direct eIF2-eIF3 contact in the multifactor complex is important for translation initiation in vivo
  publication-title: EMBO J.
  doi: 10.1093/emboj/cdf563
  contributor:
    fullname: Valasek
– volume: 26
  start-page: 811
  year: 2007
  ident: 2022120608445782700_B69
  article-title: eIF3j is located in the decoding center of the human 40S ribosomal subunit
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2007.05.019
  contributor:
    fullname: Fraser
– volume: 525
  start-page: 491
  year: 2015
  ident: 2022120608445782700_B65
  article-title: Structure of mammalian eIF3 in the context of the 43S preinitiation complex
  publication-title: Nature
  doi: 10.1038/nature14891
  contributor:
    fullname: des Georges
– volume: 159
  start-page: 134
  year: 2014
  ident: 2022120608445782700_B12
  article-title: Complementary sequence-mediated exon circularization
  publication-title: Cell
  doi: 10.1016/j.cell.2014.09.001
  contributor:
    fullname: Zhang
– volume: 50
  start-page: 9175
  year: 2022
  ident: 2022120608445782700_B70
  article-title: The DEAD-box helicase Hlc regulates basal transcription and chromatin opening of stress-responsive genes
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkac684
  contributor:
    fullname: Jia
– volume: 13
  start-page: e1685
  year: 2021
  ident: 2022120608445782700_B32
  article-title: Circular RNA translation, a path to hidden proteome
  publication-title: Wiley Interdiscip. Rev. RNA
  doi: 10.1002/wrna.1685
  contributor:
    fullname: Sinha
– volume: 10
  start-page: 200
  year: 2004
  ident: 2022120608445782700_B97
  article-title: eIF4A3 is a novel component of the exon junction complex
  publication-title: RNA
  doi: 10.1261/rna.5230104
  contributor:
    fullname: Chan
– volume: 11
  start-page: 65
  year: 2017
  ident: 2022120608445782700_B50
  article-title: The translation factors of drosophila melanogaster
  publication-title: Fly (Austin)
  doi: 10.1080/19336934.2016.1220464
  contributor:
    fullname: Marygold
– volume: 22
  start-page: 269
  year: 2015
  ident: 2022120608445782700_B85
  article-title: Structure of a yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2963
  contributor:
    fullname: Aylett
– volume: 79
  start-page: 268
  year: 2020
  ident: 2022120608445782700_B34
  article-title: An insulin-sensitive circular RNA that regulates lifespan in drosophila
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2020.06.011
  contributor:
    fullname: Weigelt
– volume: 6
  start-page: 319
  year: 2020
  ident: 2022120608445782700_B17
  article-title: Circular RNAs in cancer: biogenesis, function, and clinical significance
  publication-title: Trends Cancer
  doi: 10.1016/j.trecan.2020.01.012
  contributor:
    fullname: Li
– volume: 21
  start-page: 475
  year: 2020
  ident: 2022120608445782700_B1
  article-title: The expanding regulatory mechanisms and cellular functions of circular RNAs
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-020-0243-y
  contributor:
    fullname: Chen
– volume: 44
  start-page: 10772
  year: 2016
  ident: 2022120608445782700_B59
  article-title: Human eIF3b and eIF3a serve as the nucleation core for the assembly of eIF3 into two interconnected modules: the yeast-like core and the octamer
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw972
  contributor:
    fullname: Wagner
– volume: 522
  start-page: 111
  year: 2015
  ident: 2022120608445782700_B39
  article-title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression
  publication-title: Nature
  doi: 10.1038/nature14267
  contributor:
    fullname: Lee
– volume: 29
  start-page: 2168
  year: 2015
  ident: 2022120608445782700_B42
  article-title: Combinatorial control of drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteins
  publication-title: Genes Dev.
  doi: 10.1101/gad.270421.115
  contributor:
    fullname: Kramer
– volume: 12
  start-page: 1025
  year: 2021
  ident: 2022120608445782700_B92
  article-title: EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression
  publication-title: Cell Death. Dis.
  doi: 10.1038/s41419-021-04339-7
  contributor:
    fullname: Feng
– volume: 263
  start-page: 210
  year: 2015
  ident: 2022120608445782700_B96
  article-title: The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12240
  contributor:
    fullname: Osborne
– volume: 66
  start-page: 9
  year: 2017
  ident: 2022120608445782700_B28
  article-title: Translation of CircRNAs
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.02.021
  contributor:
    fullname: Pamudurti
– volume: 517
  start-page: 33
  year: 2015
  ident: 2022120608445782700_B74
  article-title: RNA regulons in hox 5' UTRs confer ribosome specificity to gene regulation
  publication-title: Nature
  doi: 10.1038/nature14010
  contributor:
    fullname: Xue
– volume: 18
  start-page: 560
  year: 2017
  ident: 2022120608445782700_B95
  article-title: Deletion of eIF2beta lysine stretches creates a dominant negative that affects the translation and proliferation in human cell line: a tool for arresting the cell growth
  publication-title: Cancer Biol. Ther.
  doi: 10.1080/15384047.2017.1345383
  contributor:
    fullname: Salton
– volume: 6
  start-page: eabb7426
  year: 2020
  ident: 2022120608445782700_B21
  article-title: Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abb7426
  contributor:
    fullname: Gao
– volume: 23
  start-page: 278
  year: 2021
  ident: 2022120608445782700_B35
  article-title: Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-021-00639-4
  contributor:
    fullname: Gao
– volume: 20
  start-page: 675
  year: 2019
  ident: 2022120608445782700_B2
  article-title: The biogenesis, biology and characterization of circular RNAs
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-019-0158-7
  contributor:
    fullname: Kristensen
– volume: 122
  start-page: 1933
  year: 2009
  ident: 2022120608445782700_B13
  article-title: mRNA nuclear export at a glance
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.041236
  contributor:
    fullname: Carmody
– volume: 285
  start-page: 26779
  year: 2010
  ident: 2022120608445782700_B91
  article-title: GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.119693
  contributor:
    fullname: Dmitriev
– volume: 45
  start-page: 10948
  year: 2017
  ident: 2022120608445782700_B37
  article-title: Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle
  publication-title: Nucleic. Acids. Res.
  doi: 10.1093/nar/gkx805
  contributor:
    fullname: Valasek
– volume: 6
  start-page: 26
  year: 2011
  ident: 2022120608445782700_B78
  article-title: ViennaRNA package 2.0
  publication-title: Algorithms Mol. Biol.
  doi: 10.1186/1748-7188-6-26
  contributor:
    fullname: Lorenz
– volume: 34
  start-page: 3041
  year: 2014
  ident: 2022120608445782700_B67
  article-title: Functional and biochemical characterization of human eukaryotic translation initiation factor 3 in living cells
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00663-14
  contributor:
    fullname: Wagner
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Snippet Increasing studies have revealed that a subset of circular RNAs (circRNAs) harbor an open reading frame and can act as protein-coding templates to generate...
Abstract Increasing studies have revealed that a subset of circular RNAs (circRNAs) harbor an open reading frame and can act as protein-coding templates to...
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pubmed
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StartPage 11529
SubjectTerms Animals
Cytoplasm - metabolism
Drosophila
Drosophila Proteins - metabolism
Eukaryotic Initiation Factor-3 - metabolism
Gene regulation, Chromatin and Epigenetics
Protein Biosynthesis
RNA, Circular - genetics
Title eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells
URI https://www.ncbi.nlm.nih.gov/pubmed/36330957
https://search.proquest.com/docview/2732538789
https://pubmed.ncbi.nlm.nih.gov/PMC9723666
Volume 50
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