Case 42-1979: Systemic Lupus Erythematosus

To the Editor: The case record in the October 18 issue describes a young woman with lupus erythematosus. Dr. Long explains, "Corticosteroid therapy was discontinued after three days because. . .of a steroid-induced psychosis." This was followed two days later by a generalized seizure and c...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 302; no. 9; pp. 520 - 521
Main Authors Hart, R G, Slaughter, J R
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 28.02.1980
Subjects
Adrenal Cortex Hormones - adverse effects
Female
Humans
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - drug therapy
Neurocognitive Disorders - etiology
Psychoses, Substance-Induced - etiology
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Summary:To the Editor: The case record in the October 18 issue describes a young woman with lupus erythematosus. Dr. Long explains, "Corticosteroid therapy was discontinued after three days because. . .of a steroid-induced psychosis." This was followed two days later by a generalized seizure and coma and, finally, death attributed to sepsis. We propose that Central-nervous-system (CNS) lupus is the more likely explanation for the changes in mental status and the seizures. The excellent review by Feinglass et al. describes psychiatric symptoms in 24 of 140 patients with lupus, usually as an early feature of the illness in association with . . . No extract is available for articles shorter than 400 words.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198002283020912