Nrf2 in adipocytes

White adipocytes play a key role in maintaining whole body energy homeostasis by forming white adipose tissue (WAT). The impairment of WAT formation or WAT dysfunction is clearly associated with severe metabolic disorders. Mature adipocytes are derived from differentiated preadipocytes and are pivot...

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Published in	Archives of pharmacal research Vol. 43; no. 3; pp. 350 - 360
Main Authors	Wang, Zhendi, Zuo, Zhuo, Li, Lu, Ren, Suping, Gao, Tianchang, Fu, Jingqi, Hou, Yongyong, Chen, Yanyan, Pi, Jingbo
Format	Journal Article
Language	English
Published	Seoul Pharmaceutical Society of Korea 01.03.2020 대한약학회
Subjects	Adipocytes - metabolism Animals Energy Metabolism Humans Insulin - metabolism Medicine NF-E2-Related Factor 2 - metabolism Pharmacology/Toxicology Pharmacy Review Signal Transduction 약학 Adipocytes Nrf2 Adipogenesis Insulin signaling
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Abstract	White adipocytes play a key role in maintaining whole body energy homeostasis by forming white adipose tissue (WAT). The impairment of WAT formation or WAT dysfunction is clearly associated with severe metabolic disorders. Mature adipocytes are derived from differentiated preadipocytes and are pivotal in energy storage and metabolism. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a member of a family of CNC-bZIP proteins which exert their transcriptional control on genes harboring antioxidant response elements (ARE) in partnership with small musculoaponeurotic fibrosarcoma proteins. The activation of Nrf2-ARE coordinated by specific repressor Kelch-like ECH-associated protein 1 (Keap1) regulates networks of genes controlling diverse homeostatic processes involving adaptive antioxidant response and detoxification among many other adaptive responses. Interestingly, accumulating evidence indicates that Nrf2 may act as a transcription factor in regulating the formation and function of adipose tissues, including adipogenesis, lipid metabolism and insulin sensitivity. In this mini-review, an overview on the distinct roles of Nrf2 in adipocytes is provided. While highlighting the regulatory role of Nrf2 in adipogenesis, recent key findings on Nrf2 in insulin signal transduction and energy metabolism of adipocytes are also summarized.
AbstractList	White adipocytes play a key role in maintaining whole body energy homeostasis by forming white adipose tissue (WAT). The impairment of WAT formation or WAT dysfunction is clearly associated with severe metabolic disorders. Mature adipocytes are derived from differentiated preadipocytes and are pivotal in energy storage and metabolism. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a member of a family of CNC-bZIP proteins which exert their transcriptional control on genes harboring antioxidant response elements (ARE) in partnership with small musculoaponeurotic fibrosarcoma proteins. The activation of Nrf2-ARE coordinated by specific repressor Kelch-like ECH-associated protein 1 (Keap1) regulates networks of genes controlling diverse homeostatic processes involving adaptive antioxidant response and detoxification among many other adaptive responses. Interestingly, accumulating evidence indicates that Nrf2 may act as a transcription factor in regulating the formation and function of adipose tissues, including adipogenesis, lipid metabolism and insulin sensitivity. In this mini-review, an overview on the distinct roles of Nrf2 in adipocytes is provided. While highlighting the regulatory role of Nrf2 in adipogenesis, recent key findings on Nrf2 in insulin signal transduction and energy metabolism of adipocytes are also summarized. White adipocytes play a key role in maintainingwhole body energy homeostasis by forming white adiposetissue (WAT). The impairment of WAT formation or WATdysfunction is clearly associated with severe metabolic disorders. Mature adipocytes are derived from differentiatedpreadipocytes and are pivotal in energy storage and metabolism. Nuclear factor erythroid 2-related factor 2 (Nrf2) isa member of a family of CNC-bZIP proteins which exerttheir transcriptional control on genes harboring antioxidantresponse elements (ARE) in partnership with smallmusculoaponeurotic fibrosarcoma proteins. The activationof Nrf2-ARE coordinated by specific repressor Kelch-likeECH-associated protein 1 (Keap1) regulates networks ofgenes controlling diverse homeostatic processes involvingadaptive antioxidant response and detoxification amongmany other adaptive responses. Interestingly, accumulatingevidence indicates that Nrf2 may act as a transcription factorin regulating the formation and function of adipose tissues,including adipogenesis, lipid metabolism and insulin sensitivity. In this mini-review, an overview on the distinct rolesof Nrf2 in adipocytes is provided. While highlighting the regulatory role of Nrf2 in adipogenesis, recent key findingson Nrf2 in insulin signal transduction and energy metabolismof adipocytes are also summarized. KCI Citation Count: 6
Author	Pi, Jingbo Wang, Zhendi Li, Lu Ren, Suping Hou, Yongyong Gao, Tianchang Fu, Jingqi Zuo, Zhuo Chen, Yanyan
Author_xml	– sequence: 1 givenname: Zhendi surname: Wang fullname: Wang, Zhendi organization: Program of Environmental Toxicology, School of Public Health, China Medical University – sequence: 2 givenname: Zhuo surname: Zuo fullname: Zuo, Zhuo organization: Program of Environmental Toxicology, School of Public Health, China Medical University – sequence: 3 givenname: Lu surname: Li fullname: Li, Lu organization: Program of Environmental Toxicology, School of Public Health, China Medical University – sequence: 4 givenname: Suping surname: Ren fullname: Ren, Suping organization: Program of Environmental Toxicology, School of Public Health, China Medical University – sequence: 5 givenname: Tianchang surname: Gao fullname: Gao, Tianchang organization: Program of Environmental Toxicology, School of Public Health, China Medical University – sequence: 6 givenname: Jingqi surname: Fu fullname: Fu, Jingqi organization: Program of Environmental Toxicology, School of Public Health, China Medical University – sequence: 7 givenname: Yongyong surname: Hou fullname: Hou, Yongyong organization: Program of Environmental Toxicology, School of Public Health, China Medical University – sequence: 8 givenname: Yanyan surname: Chen fullname: Chen, Yanyan email: chenyanyan_cmu@163.com organization: The First Affiliated Hospital, China Medical University – sequence: 9 givenname: Jingbo surname: Pi fullname: Pi, Jingbo email: jbpi@cmu.edu.cn, jingbopi@163.com organization: Program of Environmental Toxicology, School of Public Health, China Medical University
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Snippet	White adipocytes play a key role in maintaining whole body energy homeostasis by forming white adipose tissue (WAT). The impairment of WAT formation or WAT... White adipocytes play a key role in maintainingwhole body energy homeostasis by forming white adiposetissue (WAT). The impairment of WAT formation or...
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SubjectTerms	Adipocytes - metabolism Animals Energy Metabolism Humans Insulin - metabolism Medicine NF-E2-Related Factor 2 - metabolism Pharmacology/Toxicology Pharmacy Review Signal Transduction 약학
Title	Nrf2 in adipocytes
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