LC3/GABARAP family proteins: autophagy-(un)related functions

• Published in: The FASEB journal Vol. 30; no. 12; p. 3961
• Main Authors: Schaaf, Marco B E, Keulers, Tom G, Vooijs, Marc A, Rouschop, Kasper M A
• Format: Journal Article
• Language: English
• Published: United States 01.12.2016
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Animals; Autophagy - physiology; Homeostasis - physiology; Humans; Microtubule-Associated Proteins - metabolism; Protein Transport - physiology; Saccharomyces cerevisiae - metabolism; cancer; ATG7; autophagosome; Atg8 orthologues

From yeast to mammals, autophagy is an important mechanism for sustaining cellular homeostasis through facilitating the degradation and recycling of aged and cytotoxic components. During autophagy, cargo is captured in double-membraned vesicles, the autophagosomes, and degraded through lysosomal fus...