Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover

• Published in: Critical care medicine Vol. 40; no. 3; p. 919
• Main Authors: Beurskens, Charlotte J P, Aslami, Hamid, Kuipers, Maria T, Horn, Janneke, Vroom, Margreeth B, van Kuilenburg, André B P, Roelofs, Joris J T H, Schultz, Marcus J, Juffermans, Nicole P
• Format: Journal Article
• Language: English
• Published: United States 01.03.2012
• Subjects: Adenosine Triphosphate - metabolism; Animals; Disease Models, Animal; Hypothermia, Induced; Male; Pneumonia, Pneumococcal - metabolism; Pneumonia, Pneumococcal - microbiology; Pneumonia, Pneumococcal - prevention & control; Rats; Rats, Sprague-Dawley
• ISSN: 1530-0293
• DOI: 10.1097/CCM.0b013e3182373174

To determine the effect of induced hypothermia on bacterial growth, lung injury, and mitochondrial function in a rat model of pneumococcal pneumosepsis. Animal study. University research laboratory. Male Sprague-Dawley rats. Subjects were inoculated intratracheally with Streptococcus pneumoniae and...