TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13/STAT3 pathway

Regulatory T cells (Tregs) are an important component of the tumor microenvironment; however, the interaction between Tregs and gastric cancer cells is not completely understood. Recent studies have shown that Tregs participate in cancer cell stemness maintenance. In this study, we performed single-...

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Published inFrontiers in oncology Vol. 13; p. 1162938
Main Authors Zhao, Rou, Cao, Guanjie, Zhang, Baogui, Wei, Li, Zhang, Xiaobei, Jin, Meng, He, Baoyu, Zhang, Bin, He, Zhun, Bie, Qingli
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2023
Subjects
cancer stem cell
gastric cancer
IL-13
Oncology
TNF
Tregs
IL-13
cancer stem cell
gastric cancer
TNF
Tregs
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Summary:Regulatory T cells (Tregs) are an important component of the tumor microenvironment; however, the interaction between Tregs and gastric cancer cells is not completely understood. Recent studies have shown that Tregs participate in cancer cell stemness maintenance. In this study, we performed single-cell RNA sequencing of gastric cancer and adjacent tissues and found that Tregs with high TNF expression were recruited to gastric cancer tissues and were significantly correlated with patient survival. TNF+ Tregs significantly contribute to tumor growth and progression. Our studies have further demonstrated that TNF+ Tregs promote the stemness of gastric cancer cells through the IL13/STAT3 pathway. Therefore, blocking the interaction between TNF+ Tregs and gastric cancer cells may be a new approach in the treatment of gastric cancer.
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Edited by: Dunfa Peng, University of Miami, United States
Reviewed by: Zeyu Wang, University of Edinburgh, United Kingdom; Melanie Genoula, University of Miami, United States
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1162938