Latrunculin Analogues with Improved Biological Profiles by "Diverted Total Synthesis": Preparation, Evaluation, and Computational Analysis - Fürstner, Alois; Kirk, Douglas; Fenster, Michaël D. B.; Aïssa, Christophe; De Souza, Dominic; Nevado, Cristina; Tuttle, Tell; Thiel, Walter; Müller, Oliver (Chemistry : a European journal, 2007)
Keywords: actin; Actins - chemistry; Animals; Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis; Bridged Bicyclo Compounds, Heterocyclic - chemistry; Catalysis; chemical biology; Chemistry; Chemistry, Multidisciplinary; computational chemistry; Computer Simulation; Crystallography, X-Ray; Hydrogen Bonding; macrolides; metathesis; Mice; Models, Molecular; Molecular Structure; NIH 3T3 Cells; Physical Sciences; Science & Technology; Thermodynamics; Thiazolidines - chemical synthesis; Thiazolidines - chemistry; total synthesis; CLOSING ALKYNE METATHESIS; SMALL-MOLECULE; CRYSTAL-STRUCTURE; computational chemistry; DISRUPT MICROFILAMENT ORGANIZATION; NUCLEIC-ACIDS; actin; macrolides; CROSS-COUPLING REACTIONS; chemical biology; metathesis; NEGOMBATA-MAGNIFICA DEMOSPONGIAE; EMPIRICAL FORCE-FIELD; total synthesis; STEREOSELECTIVE-SYNTHESIS; GRIGNARD-REAGENTS