Renal tubular epithelial cell necroptosis promotes tubulointerstitial fibrosis in patients with chronic kidney disease

• Published in: The FASEB journal Vol. 36; no. 12; pp. e22625 - n/a
• Main Authors: Lin, Ziyan, Chen, Ai, Cui, Hongwang, Shang, Ruihua, Su, Tian, Li, Xiaoyan, Wang, Kekun, Yang, Jing, Gao, Keli, Lv, Jie, Shen, Jie, Wang, Shanzhi, Qi, Yonghui, Guo, Minghao, Zhu, Yongjun
• Format: Journal Article
• Language: English
• Published: United States 01.12.2022
• Subjects: Animals; chronic kidney disease; Epithelial Cells - metabolism; Fibroblast Growth Factor 2 - metabolism; Fibrosis; Humans; Interstitial fibroblasts; Kidney - metabolism; Necroptosis; Necrosis - pathology; Rats; Renal Insufficiency, Chronic - metabolism; Transforming growth factor beta 1; Transforming Growth Factor beta1 - metabolism; Tubulointerstitial fibrosis; Vimentin - metabolism; chronic kidney disease; Tubulointerstitial fibrosis; Interstitial fibroblasts; Necroptosis; Transforming growth factor beta 1

Renal fibrosis, a common pathological manifestation of virtually all types of chronic kidney disease (CKD), ultimately predisposes patients to end‐stage renal disease. However, there is no effective therapy for renal fibrosis. Our earlier studies proved that RIP3‐mediated necroptosis might be an imp...