Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis

• Published in: Cellular signalling Vol. 23; no. 1; pp. 213 - 221
• Main Authors: Yu, Wanfeng, Ritchie, Benjamin J., Su, Xuefeng, Zhou, Jing, Meigs, Thomas E., Denker, Bradley M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.01.2011
• Subjects: Amino Acid Sequence; Apoptosis; G proteins; GTP-Binding Protein alpha Subunits, G12-G13 - genetics; GTP-Binding Protein alpha Subunits, G12-G13 - metabolism; HEK293 Cells; Humans; Kidney; Molecular Sequence Data; Mutation; Polycystic kidney disease; Protein Binding; Protein Structure, Tertiary; TRPP Cation Channels - metabolism; NAAIRS; ADPKD; GST; MDCK; G proteins; Kidney; PC1; HEK; Polycystic kidney disease; Apoptosis

Most patients with autosomal dominant polycystic kidney disease (ADPKD) harbor mutations in PKD1, the gene for polycystin-1 (PC1), a transmembrane protein with a cytoplasmic C-terminus that interacts with numerous signaling molecules, including Gα12. The functions of PC1 and the mechanisms of cyst d...