The effects of programmed ventricular stimulation on plasma procainamide levels: an experimental model

• Published in: Journal of clinical pharmacology Vol. 34; no. 2; p. 184
• Main Authors: Brautigam, R T, Porter, S, Kutalek, S P
• Format: Journal Article
• Language: English
• Published: England 01.02.1994
• Subjects: Animals; Blood Pressure - physiology; Disease Models, Animal; Dogs; Electric Stimulation; Electrocardiography; Myocardial Infarction - blood; Myocardial Infarction - physiopathology; Procainamide - administration & dosage; Procainamide - blood; Tachycardia, Ventricular - etiology; Ventricular Function

To evaluate the effects of programmed ventricular stimulation on resultant plasma concentrations of intravenously administered procainamide, drug dosing was performed with and without ventricular stimulation on two separate days (48 hours apart) in 12 dogs (13 dosing trials) at > or = 14 days aft...