Mitochondrial puzzle in muscle: Linking the electron transport system to overweight

• Published in: Obesity reviews Vol. 25; no. 9; pp. e13794 - n/a
• Main Author: Casuso, Rafael A.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2024
• Subjects: beta oxidation; Body weight; Coenzyme Q; Electron transfer; Electron transport; Electron Transport - physiology; Electron transport chain; Energy expenditure; Energy Metabolism - physiology; Fatty acids; Fatty Acids - metabolism; Humans; Lactic acid; Lactic Acid - metabolism; Lipids; low calorie diet; Metabolism; Mitochondria; Mitochondria, Muscle - metabolism; Molecular modelling; Muscle, Skeletal - metabolism; Muscles; Nutrient deficiency; nutrient excess; obesity; Obesity - metabolism; Overweight; Overweight - metabolism; Oxidation; Oxidation-Reduction; respiratory supercomplexes; Skeletal muscle; Substrates; Transportation systems; Ubiquinone - analogs & derivatives; Ubiquinone - metabolism; ubiquinones; respiratory supercomplexes; electron transport chain; metabolism; skeletal muscle; obesity; coenzyme Q

Summary Human skeletal muscle mitochondria regulate energy expenditure. Research has shown that the functionality of muscle mitochondria is altered in subjects with overweight, as well as in response to nutrient excess and calorie restriction. Two metabolic features of obesity and overweight are (1)...