Klotho gene and endothelial function

The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes (e.g. arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, skin atrophy). We have demonstrated that mice deficient for the klotho gene show endothelial dysfunction as manifest...

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Published inNihon Rōnen Igakkai zasshi Vol. 43; no. 3; pp. 342 - 344
Main Authors Nagai, Ryozo, Nakamura, Tetsuya, Saito, Yuichiro, Kurabayashi, Masahiko
Format Journal Article
LanguageJapanese
Published Japan The Japan Geriatrics Society 2006
Subjects
Aging
Aging - genetics
Animals
Arteriosclerosis
Endothelial function
Endothelium, Vascular - physiology
Glucuronidase - deficiency
Glucuronidase - genetics
Humans
Mice
Mice, Transgenic
Nitric oxide
Nitric Oxide - biosynthesis
Oxidative Stress
Phenotype
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ISSN0300-9173
DOI10.3143/geriatrics.43.342

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Summary:The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes (e.g. arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, skin atrophy). We have demonstrated that mice deficient for the klotho gene show endothelial dysfunction as manifested by an attenuated response of aortic relaxation in response to acetylcholine stimulation. Systemic nitric oxide production was also significantly reduced in klotho deficient mice. Oxidative stress was increased in klotho deficient mice. The klotho gene delivery improves multiple aging phenotypes. Our findings establish the basis for the therapeutic potential of klotho gene delivery in age-related diseases.
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ISSN:0300-9173
DOI:10.3143/geriatrics.43.342