HIV-1 envelope replication and α4β7 utilization among newly infected subjects and their corresponding heterosexual partners

• Published in: Retrovirology Vol. 10; no. 1; p. 162
• Main Authors: Pena-Cruz, Victor, Etemad, Behzad, Chatziandreou, Nikolaos, Nyein, Phyu Hninn, Stock, Shannon, Reynolds, Steven J, Laeyendecker, Oliver, Gray, Ronald H, Serwadda, David, Lee, Sandra J, Quinn, Thomas C, Sagar, Manish
• Format: Journal Article
• Language: English
• Published: England BioMed Central 26.12.2013
• Subjects: CD4-Positive T-Lymphocytes - virology; CD8-Positive T-Lymphocytes - virology; Cells, Cultured; Coculture Techniques; Cohort Studies; Dendritic Cells - virology; env Gene Products, Human Immunodeficiency Virus - genetics; Family Characteristics; Female; Heterosexuality; HIV Infections - transmission; HIV Infections - virology; HIV-1 - classification; HIV-1 - genetics; HIV-1 - isolation & purification; Humans; Integrins - metabolism; Macrophages - virology; Male; Receptors, HIV - metabolism; Selection, Genetic

Previous studies suggest that active selection limits the number of HIV-1 variants acquired by a newly infected individual from the diverse variants circulating in the transmitting partner. We compared HIV-1 envelopes from 9 newly infected subjects and their linked transmitting partner to explore po...