Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4+ T Lymphocytes from Effector Sites in the Gastrointestinal Tract

• Published in: The Journal of experimental medicine Vol. 200; no. 6; pp. 761 - 770
• Main Authors: Mehandru, Saurabh, Poles, Michael A., Tenner-Racz, Klara, Horowitz, Amir, Hurley, Arlene, Hogan, Christine, Boden, Daniel, Racz, Paul, Markowitz, Martin
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 20.09.2004
• Subjects: Acquired Immunodeficiency Syndrome - drug therapy; Acquired Immunodeficiency Syndrome - immunology; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes - immunology; Digestive System - immunology; Digestive System - virology; HIV-1; Humans; Intestinal Mucosa - immunology; Receptors, CCR5 - analysis
• ISSN: 0022-1007; 1540-9538
• DOI: 10.1084/jem.20041196

Given its population of CCR5-expressing, immunologically activated CD4+ T cells, the gastrointestinal (GI) mucosa is uniquely susceptible to human immunodeficiency virus (HIV)-1 infection. We undertook this study to assess whether a preferential depletion of mucosal CD4+ T cells would be observed in...