Impaired Trafficking of Connexins in Androgen-independent Human Prostate Cancer Cell Lines and Its Mitigation by α-Catenin

• Published in: The Journal of biological chemistry Vol. 277; no. 51; pp. 50087 - 50097
• Main Authors: Govindarajan, Rajgopal, Zhao, Sumin, Song, Xiao-Hong, Guo, Rong-Jun, Wheelock, Margaret, Johnson, Keith R., Mehta, Parmender P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.12.2002
• Subjects: alpha Catenin; Biotinylation; Blotting, Western; Cell Membrane - metabolism; Connexin 43 - metabolism; Connexins - metabolism; Cysteine Endopeptidases - metabolism; Cytoskeletal Proteins - metabolism; DNA, Complementary - metabolism; Epithelial Cells - metabolism; Gap Junction beta-1 Protein; Gap Junctions - metabolism; Humans; Lysosomes - metabolism; Male; Multienzyme Complexes - metabolism; Octoxynol - pharmacology; Plasmids - metabolism; Prostatic Neoplasms - metabolism; Proteasome Endopeptidase Complex; Protein Binding; Protein Transport; Retroviridae - genetics; Transfection; Tumor Cells, Cultured

Gap junctions, composed of connexins, provide a pathway of direct intercellular communication for the diffusion of small molecules between cells. Evidence suggests that connexins act as tumor suppressors. We showed previously that expression of connexin-43 and connexin-32 in an indolent prostate can...