The challenge to further improvements in survival of patients with T-ALL: Current treatments and new insights from disease pathogenesis

• Published in: Seminars in hematology Vol. 57; no. 3; p. 149
• Main Author: O'Dwyer, Kristen M
• Format: Journal Article
• Language: English
• Published: United States 01.07.2020
• Subjects: Adolescent; Adult; Humans; Immunotherapy - methods; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality; Survival Rate; Young Adult; Pediatric inspired treatment; Survival pathways; Immunotherapy for T-cell ALL; T-cell acute lymphoblastic leukemia

Survival rates for children and adult patients with T-cell acute lymphoblastic leukemia (T-ALL) have improved during the past decade due to optimization of frontline multiagent chemotherapy regimens. The outcome for relapsed T-ALL after initial intensive chemotherapy is frequently fatal, however, be...