Protein kinase inhibitors’ classification using K-Nearest neighbor algorithm

• Published in: Computational biology and chemistry Vol. 86; p. 107269
• Main Authors: Arian, Roya, Hariri, Amirali, Mehridehnavi, Alireza, Fassihi, Afshin, Ghasemi, Fahimeh
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2020
• Subjects: Algorithms; Antineoplastic Agents - chemistry; Antineoplastic Agents - classification; Bayes Theorem; Classification model; Genetic algorithm; K-nearest neighbor; Protein kinase; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - classification; QSAR; Quantitative Structure-Activity Relationship; Classification model; Protein kinase; QSAR; Genetic algorithm; K-nearest neighbor

[Display omitted] •Protein kinases are enzymes acting as a source of phosphate through ATP to regulate protein biological activities.•Inhibiting protein kinases with an active small molecule plays a significant role in cancer treatment.•To achieve this aim, QSAR model, is one of the best economical...