Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats

• Published in: Brain research bulletin Vol. 167; pp. 37 - 47
• Main Authors: Aglawe, Manish M., Kale, Mayur B., Rahangdale, Sandip R., Kotagale, Nandkishor R., Umekar, Milind J., Taksande, Brijesh G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2021
• Subjects: Agmatine; Agmatine - pharmacology; Animals; Anxiety; Behavior, Animal - drug effects; Central Nervous System Depressants - toxicity; Cognitive Dysfunction - etiology; Depression; Ethanol - toxicity; Female; Fetal Alcohol Spectrum Disorders; Fetal alcohol syndrome; Hippocampus - drug effects; Maze Learning - drug effects; Memory impairment; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Fetal alcohol syndrome; Memory impairment; Depression; Anxiety; Agmatine

•Prenatal ethanol exposure impaired cognition and neurological symptoms.•Reduced hippocampal agmatine and BDNF were associated with neurocognitive impairments.•Postnatal agmatine administration improved cognition and alleviated anxiety behavior.•Postnatal agmatine treatment increased BDNF and reduce...