Structure and Anti-HIV Activity of Betulinic Acid Analogues

• Published in: Current medical science Vol. 38; no. 3; pp. 387 - 397
• Main Authors: Huang, Qiu-xia, Chen, Hong-fei, Luo, Xing-rui, Zhang, Yin-xiang, Yao, Xu, Zheng, Xing
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.06.2018; University of South China, Hengyang 421001, China; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang 421001, China
• Subjects: Medicine; Medicine & Public Health; structure activity relationship; HIV; structural modification; betulinic acid analogues

Summary Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especi...