HPV16 induces a wasting syndrome in transgenic mice: Amelioration by dietary polyphenols via NF-κB inhibition

• Published in: Life sciences (1973) Vol. 169; pp. 11 - 19
• Main Authors: Gil da Costa, Rui M., Aragão, Sofia, Moutinho, Magda, Alvarado, Antonieta, Carmo, Diogo, Casaca, Fátima, Silva, Sandra, Ribeiro, Joana, Sousa, Hugo, Ferreira, Rita, Nogueira-Ferreira, Rita, Pires, Maria João, Colaço, Bruno, Medeiros, Rui, Venâncio, Carlos, Oliveira, Maria Manuel, Bastos, Margarida M.S.M., Lopes, Carlos, Oliveira, Paula A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.01.2017
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Cachexia; Cachexia - complications; Cachexia - drug therapy; Cachexia - pathology; Cachexia - virology; Cancer; Curcumin; Curcumin - therapeutic use; Female; HPV; Human papillomavirus 16 - immunology; Humans; Inflammation - complications; Inflammation - drug therapy; Inflammation - pathology; Inflammation - virology; Mice, Transgenic; Muscle, Skeletal - drug effects; Muscle, Skeletal - pathology; Muscle, Skeletal - virology; NF-kappa B - antagonists & inhibitors; NF-kappa B - immunology; NF-κB; Rutin; Rutin - therapeutic use; Skin - drug effects; Skin - pathology; Skin - virology; Skin Neoplasms - complications; Skin Neoplasms - drug therapy; Skin Neoplasms - pathology; Skin Neoplasms - virology; Wasting Syndrome - complications; Wasting Syndrome - drug therapy; Wasting Syndrome - pathology; Wasting Syndrome - virology; NF-κB; Curcumin; Cachexia; Rutin; Cancer; HPV

Cancer patients often show a wasting syndrome for which there are little therapeutic options. Dietary polyphenols have been proposed for treating this syndrome, but their usefulness in cases associated with human papillomavirus (HPV)-induced cancers is unknown. We characterized HPV16-transgenic mice...