Discovery of novel 6-(piperidin-1-ylsulfonyl)-2H-chromenes targeting α-glucosidase, α-amylase, and PPAR-γ: Design, synthesis, virtual screening, and anti-diabetic activity for type 2 diabetes mellitus

• Published in: Computational biology and chemistry Vol. 111; p. 108097
• Main Authors: Thabet, Hamdy Khamees, Abusaif, Moustafa S., Imran, Mohd, Helal, Mohamed Hamdy, Alaqel, Saleh Ibrahim, Alshehri, Ahmed, Mohd, Abida Ash, Ammar, Yousry A., Ragab, Ahmed
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2024
• Subjects: 6-sulfonamide-2H-chromenes; ADME prediction; Diabetes mellitus; Molecular docking simulation; Structural activity relationship (SAR); 6-sulfonamide-2H-chromenes; ADME prediction; Molecular docking simulation; Diabetes mellitus; Structural activity relationship (SAR)

A new series of 2H-chromene-based sulfonamide derivatives 3-12 has been synthesized and characterized using different spectroscopic techniques. The synthesized 2H-chromenes were synthesized by reacting activated methylene with 5-(piperidin-1-ylsulfonyl)salicylaldehyde through one-step condensation f...