Interleukin-9 Enhances Resistance to the Intestinal Nematode Trichuris muris

Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the...

Full description

Saved in:
Bibliographic Details
Published inInfection and Immunity Vol. 66; no. 8; pp. 3832 - 3840
Main Authors FAULKNER, H, RENAULD, J.-C, VAN SNICK, J, GRENCIS, R. K
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.08.1998
Subjects
AIDS/HIV
Analysis of the immune response. Humoral and cellular immunity
Animals
Biological and medical sciences
Cell Line
Experimental helminthic diseases. Models
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Fungal and Parasitic Infections
Gene Expression
Helminthic diseases
Immunity, Innate - immunology
Immunobiology
Infectious diseases
Interleukin-9 - genetics
Interleukin-9 - immunology
Lymphokines, interleukins ( function, expression)
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Transgenic
Parasitic diseases
Regulatory factors and their cellular receptors
Th2 Cells - immunology
Trichuriasis - immunology
Trichuriasis - metabolism
Trichuris - immunology
Animal model
Host parasite relation
Immune response
Pathogenesis
Cytokine
Rodentia
Cellular immunity
Parasitosis
Helminthiasis
Infection
Vertebrata
Experimental disease
Mammalia
Sensitivity resistance
Mouse
Nematode disease
Helmintha
Digestive diseases
Intestinal disease
Nemathelminthia
Invertebrata
Nematoda
Interleukin 9
Online AccessGet full text

Cover

Abstract Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy Connect to IAI IAI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0019-9567 Online ISSN: 1098-5522 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to IAI .asm.org, visit: IAI       
AbstractList Upon infection with the cecum-dwelling nematode Trichuris muris, the majority of inbred strains of mice launch a Th2-type immune response and in doing so expel the parasite before patency. In contrast, there are a few mouse strains which develop a nonprotective Th1-type response resulting in a chronic infection and the presence of adult worms. Of the Th2 cytokines known to be associated with the resistant phenotype (interleukin-4 [IL-4], IL-5, IL-9, and IL-13), comparatively little is known about the contribution that IL-9 makes towards the protective immune response. In this study we demonstrate that IL-9 is expressed early during the Th2-type response and that its elevation in vivo results in the enhancement of intestinal mastocytosis and the production of both the immunoglobulin E (IgE) and IgG1 isotypes. In addition, elevated IL-9 levels in vivo facilitated the loss of T. muris from the intestine. That IL-9 is important in promoting worm expulsion was also seen following infection of IL-9-transgenic mice, which constitutively overexpress the cytokine. These animals displayed an extremely rapid, but immune mediated, expulsion of the parasite. Also evident in these animals was a pronounced intestinal mastocytosis, which was previously shown by us to be responsible for the expulsion of the related nematode Trichinella spiralis from these animals. Taken together with observations of IL-9 production following infection with other helminths, the results imply that IL-9 contributes to the general mast cell and IgE response characteristic of these infections and, more specifically, enhances resistance to T. muris.
Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy Connect to IAI IAI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0019-9567 Online ISSN: 1098-5522 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to IAI .asm.org, visit: IAI       
ABSTRACT Upon infection with the cecum-dwelling nematode Trichuris muris , the majority of inbred strains of mice launch a Th2-type immune response and in doing so expel the parasite before patency. In contrast, there are a few mouse strains which develop a nonprotective Th1-type response resulting in a chronic infection and the presence of adult worms. Of the Th2 cytokines known to be associated with the resistant phenotype (interleukin-4 [IL-4], IL-5, IL-9, and IL-13), comparatively little is known about the contribution that IL-9 makes towards the protective immune response. In this study we demonstrate that IL-9 is expressed early during the Th2-type response and that its elevation in vivo results in the enhancement of intestinal mastocytosis and the production of both the immunoglobulin E (IgE) and IgG1 isotypes. In addition, elevated IL-9 levels in vivo facilitated the loss of T. muris from the intestine. That IL-9 is important in promoting worm expulsion was also seen following infection of IL-9-transgenic mice, which constitutively overexpress the cytokine. These animals displayed an extremely rapid, but immune mediated, expulsion of the parasite. Also evident in these animals was a pronounced intestinal mastocytosis, which was previously shown by us to be responsible for the expulsion of the related nematode Trichinella spiralis from these animals. Taken together with observations of IL-9 production following infection with other helminths, the results imply that IL-9 contributes to the general mast cell and IgE response characteristic of these infections and, more specifically, enhances resistance to T. muris .
Upon infection with the cecum-dwelling nematode Trichuris muris , the majority of inbred strains of mice launch a Th2-type immune response and in doing so expel the parasite before patency. In contrast, there are a few mouse strains which develop a nonprotective Th1-type response resulting in a chronic infection and the presence of adult worms. Of the Th2 cytokines known to be associated with the resistant phenotype (interleukin-4 [IL-4], IL-5, IL-9, and IL-13), comparatively little is known about the contribution that IL-9 makes towards the protective immune response. In this study we demonstrate that IL-9 is expressed early during the Th2-type response and that its elevation in vivo results in the enhancement of intestinal mastocytosis and the production of both the immunoglobulin E (IgE) and IgG1 isotypes. In addition, elevated IL-9 levels in vivo facilitated the loss of T. muris from the intestine. That IL-9 is important in promoting worm expulsion was also seen following infection of IL-9-transgenic mice, which constitutively overexpress the cytokine. These animals displayed an extremely rapid, but immune mediated, expulsion of the parasite. Also evident in these animals was a pronounced intestinal mastocytosis, which was previously shown by us to be responsible for the expulsion of the related nematode Trichinella spiralis from these animals. Taken together with observations of IL-9 production following infection with other helminths, the results imply that IL-9 contributes to the general mast cell and IgE response characteristic of these infections and, more specifically, enhances resistance to T. muris .
Author J. Van Snick
R. K. Grencis
J.-C. Renauld
Helen Faulkner
AuthorAffiliation School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom, 1 and Brussels Branch, Ludwig Institute for Cancer Research, and Experimental Medicine Unit, Catholic University of Louvain, Brussels, Belgium 2
AuthorAffiliation_xml – name: School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom, 1 and Brussels Branch, Ludwig Institute for Cancer Research, and Experimental Medicine Unit, Catholic University of Louvain, Brussels, Belgium 2
Author_xml – sequence: 1
  givenname: H
  surname: FAULKNER
  fullname: FAULKNER, H
  organization: School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
– sequence: 2
  givenname: J.-C
  surname: RENAULD
  fullname: RENAULD, J.-C
  organization: Brussels Branch, Ludwig Institute for Cancer Research, and Experimental Medicine Unit, Catholic University of Louvain, Brussels, Belgium
– sequence: 3
  givenname: J
  surname: VAN SNICK
  fullname: VAN SNICK, J
  organization: Brussels Branch, Ludwig Institute for Cancer Research, and Experimental Medicine Unit, Catholic University of Louvain, Brussels, Belgium
– sequence: 4
  givenname: R. K
  surname: GRENCIS
  fullname: GRENCIS, R. K
  organization: School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2393543$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/9673269$$D View this record in MEDLINE/PubMed
BookMark eNqFkcFu3CAQhlGVKtkkfYQqrhTl5i0wGMOhhyhK05VWrVQlZ8Sy45jGxgnYqfL2xdrVqj31AgPz_QMz_yk5CkNAQi4YXTLG1efV9Wop5VItQQEvQYl8r7V6RxaMalVWFedHZEEp06WuZH1CTlP6lY9CCHVMjrWsgUu9IOtVGDF2OD35UOriNrQ2OEzFT0w-jXNcjEMxtljMYBp9sF3xHXs7Dlss7qN37RR9Kvp5PSfvG9sl_LDfz8jD19v7m2_l-sfd6uZ6XTpQdCydbKDiANbSSm61whxjY2um6w2jUuNGMZAgK9gIDVRQpRFc5ZiSjNYNwhn5sqv7PG163DoMY7SdeY6-t_HNDNabfzPBt-ZxeDWMKsF11l_t9XF4mXJXpvfJYdfZgMOUjMqDqiXU_wWZFJozJTJY70AXh5QiNofPMGpmw0w2zEhplJkNM7NhZjYsKz_-3ctBt3co5y_3eZuc7ZqYPfHpgHHQUAnI2Kcd1vrH9rePaGzqjc-TODwKfwDU4KuQ
CODEN INFIBR
CitedBy_id crossref_primary_10_1016_j_immuni_2013_07_020
crossref_primary_10_1517_14712598_1_4_641
crossref_primary_10_1371_journal_pntd_0006481
crossref_primary_10_1111_j_1749_6632_2011_06351_x
crossref_primary_10_1016_j_jaci_2015_01_021
crossref_primary_10_1111_j_1365_2567_2009_03114_x
crossref_primary_10_1186_s13567_022_01055_8
crossref_primary_10_1038_s41598_018_26907_2
crossref_primary_10_1046_j_1365_3024_2003_00630_x
crossref_primary_10_4049_jimmunol_164_8_4229
crossref_primary_10_4049_jimmunol_168_5_2383
crossref_primary_10_3390_pathogens10080925
crossref_primary_10_1111_j_0141_9838_2004_00730_x
crossref_primary_10_3390_ijms21010236
crossref_primary_10_4049_jimmunol_1900310
crossref_primary_10_3389_fimmu_2020_01286
crossref_primary_10_1007_s00281_016_0606_9
crossref_primary_10_1038_ni_1659
crossref_primary_10_1371_journal_ppat_1003913
crossref_primary_10_1007_s11908_002_0068_1
crossref_primary_10_1038_nri1460
crossref_primary_10_1038_nri1183
crossref_primary_10_1002_eji_200425452
crossref_primary_10_1067_mai_2001_114989
crossref_primary_10_1038_s41598_018_26194_x
crossref_primary_10_4049_jimmunol_164_8_4197
crossref_primary_10_1111_j_0105_2896_2004_00192_x
crossref_primary_10_4049_jimmunol_165_1_344
crossref_primary_10_1093_cvr_cvv110
crossref_primary_10_4049_jimmunol_166_7_4391
crossref_primary_10_1016_j_cyto_2004_01_006
crossref_primary_10_1371_journal_ppat_1003905
crossref_primary_10_1038_s41598_024_51616_4
crossref_primary_10_1111_pim_12094
crossref_primary_10_4049_jimmunol_2300094
crossref_primary_10_1002_eji_200324364
crossref_primary_10_1111_pim_12090
crossref_primary_10_1016_j_aller_2018_02_003
crossref_primary_10_1051_medsci_20163204017
crossref_primary_10_1155_2010_562356
crossref_primary_10_4049_jimmunol_174_4_2205
crossref_primary_10_1084_jem_190_7_953
crossref_primary_10_1007_s10875_013_9936_8
crossref_primary_10_1111_pim_12895
crossref_primary_10_1111_j_1365_2567_2008_03010_x
crossref_primary_10_1196_annals_1443_023
crossref_primary_10_1046_j_1365_3024_2002_00452_x
crossref_primary_10_1371_journal_pntd_0004317
crossref_primary_10_1369_0022155414545334
crossref_primary_10_3390_biom10010116
crossref_primary_10_1073_pnas_97_2_767
crossref_primary_10_1038_ni_2133
crossref_primary_10_4049_jimmunol_0801941
crossref_primary_10_1006_cimm_1999_1474
crossref_primary_10_1007_s00281_012_0348_2
crossref_primary_10_1042_CS20140608
crossref_primary_10_1016_j_cyto_2015_12_020
crossref_primary_10_1189_jlb_3VMA1015_476R
crossref_primary_10_3389_fimmu_2022_932090
crossref_primary_10_4049_jimmunol_164_11_5549
crossref_primary_10_1038_ni_1867
crossref_primary_10_1128_IAI_68_10_6005_6011_2000
crossref_primary_10_3390_ijms222413310
crossref_primary_10_1002_eji_201646842
crossref_primary_10_1111_j_1365_3024_2009_01147_x
crossref_primary_10_1002_eji_200324264
crossref_primary_10_1128_IAI_00646_13
crossref_primary_10_1038_nri3824
crossref_primary_10_4049_jimmunol_176_4_2505
crossref_primary_10_1038_ni_2303
crossref_primary_10_1086_317537
crossref_primary_10_1038_nm_2731
crossref_primary_10_1007_s00281_016_0605_x
crossref_primary_10_1017_S0031182011000084
crossref_primary_10_3389_fimmu_2014_00487
crossref_primary_10_1128_IAI_73_7_4025_4033_2005
crossref_primary_10_4049_jimmunol_164_11_5556
crossref_primary_10_1080_08830180213278
crossref_primary_10_1126_scitranslmed_3007828
crossref_primary_10_1371_journal_pntd_0008218
crossref_primary_10_1002_bem_22219
crossref_primary_10_1128_IAI_00469_19
crossref_primary_10_1111_j_1365_2567_2008_02893_x
crossref_primary_10_1111_pim_12566
crossref_primary_10_2332_allergolint_55_105
crossref_primary_10_1111_j_1365_3024_2006_00923_x
crossref_primary_10_1128_IAI_71_5_2430_2438_2003
crossref_primary_10_1002_gepi_0187
crossref_primary_10_1038_nrdp_2017_98
crossref_primary_10_3892_etm_2016_3870
crossref_primary_10_1146_annurev_immunol_032713_120218
crossref_primary_10_4049_jimmunol_1003049
crossref_primary_10_4049_jimmunol_175_10_6713
crossref_primary_10_1007_s00508_007_0914_0
crossref_primary_10_4049_jimmunol_170_9_4693
crossref_primary_10_1371_journal_ppat_1009768
crossref_primary_10_3390_immuno3020015
crossref_primary_10_3347_kjp_2000_38_4_209
crossref_primary_10_3390_ani10112137
crossref_primary_10_1038_ncomms5575
crossref_primary_10_1016_j_vetpar_2021_109398
crossref_primary_10_1111_imr_12634
crossref_primary_10_1155_2015_519638
crossref_primary_10_1186_s12865_020_00394_5
crossref_primary_10_1016_S1074_7613_00_00056_X
crossref_primary_10_1111_j_0105_2896_2004_00193_x
Cites_doi 10.1002/eji.1830191130
10.1017/S0031182000080173
10.1146/annurev.immunol.15.1.505
10.1084/jem.173.2.507
10.1016/0022-1759(93)90386-L
10.1128/iai.64.8.2950-2954.1996
10.1016/S0171-2985(11)80414-6
10.1084/jem.184.5.1651
10.1002/eji.1830271011
10.1073/pnas.83.6.1857
10.4049/jimmunol.142.10.3440
10.4049/jimmunol.147.2.554
10.4049/jimmunol.160.7.3453
10.4049/jimmunol.151.8.4266
10.1084/jem.173.2.519
10.1182/blood.V75.12.2271.2271
10.1046/j.1365-3024.1996.d01-115.x
10.4049/jimmunol.150.8.3434
10.4049/jimmunol.134.2.910
10.1017/S0031182000072395
10.4049/jimmunol.153.9.3989
10.1073/pnas.85.18.6934
10.1002/eji.1830230743
10.4049/jimmunol.144.11.4235
10.1006/expr.1996.0090
10.1016/0167-5699(93)90318-F
10.1111/pim.1993.15.10.595
10.1111/j.1365-3024.1992.tb00018.x
10.4049/jimmunol.160.8.3989
10.4049/jimmunol.159.6.2616
10.4049/jimmunol.151.3.1235
10.1038/383787a0
10.1111/j.1365-3024.1990.tb00938.x
ContentType Journal Article
Copyright 1998 INIST-CNRS
Copyright © 1998, American Society for Microbiology 1998
Copyright_xml – notice: 1998 INIST-CNRS
– notice: Copyright © 1998, American Society for Microbiology 1998
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7T5
H94
7X8
5PM
DOI 10.1128/IAI.66.8.3832-3840.1998
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Immunology Abstracts
AIDS and Cancer Research Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
AIDS and Cancer Research Abstracts
Immunology Abstracts
MEDLINE - Academic
DatabaseTitleList AIDS and Cancer Research Abstracts

MEDLINE
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1098-5522
EndPage 3840
ExternalDocumentID 10_1128_IAI_66_8_3832_3840_1998
9673269
2393543
iai_66_8_3832
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-DZ
-~X
.55
.GJ
08R
0R~
18M
29I
2WC
39C
3O-
4.4
41~
53G
5GY
5RE
5VS
85S
AAPBV
AAUGY
ABOCM
ACGFO
ADBBV
AENEX
AFMIJ
AGCDD
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CS3
D0S
DIK
DU5
E3Z
EBS
EJD
F5P
FRP
GX1
H13
HYE
HZ~
H~9
IH2
IQODW
J5H
KQ8
L7B
MVM
NEJ
O9-
OHT
OK1
P2P
RHF
RHI
RNS
RPM
RSF
SJN
TR2
TWZ
UCJ
UPT
VH1
VQA
W2D
W8F
WH7
WHG
WOQ
X7M
XFK
Y6R
ZA5
ZGI
ZXP
~KM
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
AGVNZ
CITATION
7T5
H94
7X8
5PM
ID FETCH-LOGICAL-c380t-c6f35233aa056d98e233efa7197b1069eb81363653b49304089e3c5c186107fe3
IEDL.DBID RPM
ISSN 0019-9567
IngestDate Tue Sep 17 21:22:52 EDT 2024
Fri Aug 16 23:18:47 EDT 2024
Fri Aug 16 01:18:39 EDT 2024
Thu Sep 12 20:09:03 EDT 2024
Thu May 23 23:01:06 EDT 2024
Sun Oct 29 17:09:20 EDT 2023
Wed May 18 15:27:12 EDT 2016
IsPeerReviewed true
IsScholarly true
Issue 8
Keywords Animal model
Host parasite relation
Immune response
Pathogenesis
Cytokine
Rodentia
Cellular immunity
Parasitosis
Helminthiasis
Infection
Vertebrata
Experimental disease
Mammalia
Sensitivity resistance
Mouse
Nematode disease
Helmintha
Digestive diseases
Intestinal disease
Nemathelminthia
Invertebrata
Nematoda
Interleukin 9
Language English
License CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c380t-c6f35233aa056d98e233efa7197b1069eb81363653b49304089e3c5c186107fe3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Editor: S. H. E. Kaufmann
Corresponding author. Present address: Department of Biological Sciences, University of Salford, Peel Building, The Crescent, Salford M5 4WT, United Kingdom. Phone: 44 161 295 4069. Fax: 44 161 295 5210. E-mail: H.Faulkner@biosci.salfcrd.ac.uk.
PMID 9673269
PQID 16492184
PQPubID 23462
PageCount 9
ParticipantIDs proquest_miscellaneous_80017637
crossref_primary_10_1128_IAI_66_8_3832_3840_1998
proquest_miscellaneous_16492184
pascalfrancis_primary_2393543
pubmedcentral_primary_oai_pubmedcentral_nih_gov_108429
pubmed_primary_9673269
highwire_asm_iai_66_8_3832
PublicationCentury 1900
PublicationDate 1998-08-01
PublicationDateYYYYMMDD 1998-08-01
PublicationDate_xml – month: 08
  year: 1998
  text: 1998-08-01
  day: 01
PublicationDecade 1990
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
– name: United States
PublicationTitle Infection and Immunity
PublicationTitleAlternate Infect Immun
PublicationYear 1998
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References 3137580 - Proc Natl Acad Sci U S A. 1988 Sep;85(18):6934-8
7686199 - J Immunol Methods. 1993 Jun 18;162(2):211-23
1532377 - Immunology. 1992 Feb;75(2):232-7
8893001 - Nature. 1996 Oct 31;383(6603):787-93
9368607 - Eur J Immunol. 1997 Oct;27(10):2536-40
2937061 - Proc Natl Acad Sci U S A. 1986 Mar;83(6):1857-61
8468481 - J Immunol. 1993 Apr 15;150(8 Pt 1):3434-41
7686859 - Eur J Immunol. 1993 Jul;23(7):1687-92
1899107 - J Exp Med. 1991 Feb 1;173(2):519-22
8509135 - Immunology. 1993 May;79(1):146-51
3065218 - Immunology. 1988 Dec;65(4):559-66
2179829 - Parasite Immunol. 1990 Jan;12(1):85-95
8920855 - J Exp Med. 1996 Nov 1;184(5):1651-61
3136419 - Parasitology. 1988 Jun;96 ( Pt 3):543-50
8393043 - J Immunol. 1993 Aug 1;151(3):1235-44
7691943 - J Immunol. 1993 Oct 15;151(8):4266-73
7930607 - J Immunol. 1994 Nov 1;153(9):3989-96
7508174 - Adv Immunol. 1994;55:1-96
3323034 - Immunology. 1987 Dec;62(4):629-34
6048569 - Parasitology. 1967 Aug;57(3):515-24
9300680 - J Immunol. 1997 Sep 15;159(6):2616-23
8125519 - Immunobiology. 1993 Dec;189(5):419-35
8442856 - Immunol Today. 1993 Jan;14(1):15-7
9229389 - Parasite Immunol. 1996 Jul;18(7):359-69
1437236 - Parasite Immunol. 1992 Jul;14(4):441-9
2856931 - J Immunol. 1985 Feb;134(2):910-4
8152793 - Oncogene. 1994 May;9(5):1327-32
9531306 - J Immunol. 1998 Apr 1;160(7):3453-61
8888733 - Exp Parasitol. 1996 Oct;84(1):65-73
9558107 - J Immunol. 1998 Apr 15;160(8):3989-96
1971295 - J Immunol. 1990 Jun 1;144(11):4235-41
1649220 - J Immunol. 1991 Jul 15;147(2):554-60
9143698 - Annu Rev Immunol. 1997;15:505-33
1693525 - Blood. 1990 Jun 15;75(12):2271-5
7877836 - Parasite Immunol. 1993 Oct;15(10):595-600
1903765 - Immunology. 1991 Apr;72(4):508-13
2574683 - Eur J Immunol. 1989 Nov;19(11):2167-70
8757819 - Infect Immun. 1996 Aug;64(8):2950-4
2785556 - J Immunol. 1989 May 15;142(10):3440-6
1899106 - J Exp Med. 1991 Feb 1;173(2):507-10
1836201 - Immunology. 1991 Oct;74(2):329-32
e_1_3_2_27_2
Petit-Frère C. (e_1_3_2_30_2) 1993; 79
e_1_3_2_28_2
e_1_3_2_41_2
e_1_3_2_40_2
e_1_3_2_43_2
e_1_3_2_42_2
Hültner L. (e_1_3_2_21_2) 1989; 142
e_1_3_2_22_2
Eklund K. K. (e_1_3_2_7_2) 1993; 151
e_1_3_2_23_2
Galli S. J. (e_1_3_2_17_2) 1994; 55
Finkelman F. D. (e_1_3_2_15_2) 1993; 151
Grencis R. K. (e_1_3_2_20_2) 1991; 74
Newlands G. F. J. (e_1_3_2_29_2) 1987; 62
Svetic A. (e_1_3_2_39_2) 1993; 150
Monteyne P. (e_1_3_2_25_2) 1997; 159
e_1_3_2_9_2
e_1_3_2_38_2
e_1_3_2_16_2
e_1_3_2_37_2
Renauld J.-C. (e_1_3_2_32_2) 1994; 9
e_1_3_2_6_2
e_1_3_2_18_2
e_1_3_2_19_2
Miller H. R. P. (e_1_3_2_24_2) 1988; 65
Renauld J.-C. (e_1_3_2_31_2) 1990; 144
e_1_3_2_10_2
Rennick D. M. (e_1_3_2_33_2) 1985; 134
e_1_3_2_5_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_4_2
Bancroft A. J. (e_1_3_2_3_2) 1998; 160
e_1_3_2_13_2
e_1_3_2_36_2
e_1_3_2_2_2
e_1_3_2_14_2
Montgomery R. A. (e_1_3_2_26_2) 1991; 147
Schmitt E. (e_1_3_2_35_2) 1994; 153
Else K. J. (e_1_3_2_12_2) 1992; 75
Else K. J. (e_1_3_2_8_2) 1991; 72
References_xml – ident: e_1_3_2_34_2
  doi: 10.1002/eji.1830191130
– volume: 65
  start-page: 559
  year: 1988
  ident: e_1_3_2_24_2
  article-title: Granule proteinases define mast cell heterogeneity in the serosa and the gastrointestinal mucosa of the mouse
  publication-title: Immunology
  contributor:
    fullname: Miller H. R. P.
– ident: e_1_3_2_10_2
  doi: 10.1017/S0031182000080173
– ident: e_1_3_2_16_2
  doi: 10.1146/annurev.immunol.15.1.505
– ident: e_1_3_2_40_2
  doi: 10.1084/jem.173.2.507
– ident: e_1_3_2_28_2
  doi: 10.1016/0022-1759(93)90386-L
– volume: 55
  start-page: 1
  year: 1994
  ident: e_1_3_2_17_2
  article-title: The kit ligand, stem cell factor
  publication-title: Adv. Immunol.
  contributor:
    fullname: Galli S. J.
– ident: e_1_3_2_9_2
  doi: 10.1128/iai.64.8.2950-2954.1996
– ident: e_1_3_2_18_2
  doi: 10.1016/S0171-2985(11)80414-6
– ident: e_1_3_2_27_2
  doi: 10.1084/jem.184.5.1651
– volume: 75
  start-page: 232
  year: 1992
  ident: e_1_3_2_12_2
  article-title: Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of Th-cell subsets in resistant and susceptible mice
  publication-title: Immunology.
  contributor:
    fullname: Else K. J.
– ident: e_1_3_2_14_2
  doi: 10.1002/eji.1830271011
– ident: e_1_3_2_4_2
– ident: e_1_3_2_36_2
  doi: 10.1073/pnas.83.6.1857
– volume: 142
  start-page: 3440
  year: 1989
  ident: e_1_3_2_21_2
  article-title: Thiol-sensitive mast cell lines derived from mouse bone marrow respond to a mast cell growth-enhancing activity different from both IL-3 and IL-4
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.142.10.3440
  contributor:
    fullname: Hültner L.
– volume: 147
  start-page: 554
  year: 1991
  ident: e_1_3_2_26_2
  article-title: Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.147.2.554
  contributor:
    fullname: Montgomery R. A.
– volume: 9
  start-page: 1327
  year: 1994
  ident: e_1_3_2_32_2
  article-title: Thymic lymphomas in interleukin-9 transgenic mice
  publication-title: Oncogene
  contributor:
    fullname: Renauld J.-C.
– volume: 160
  start-page: 3453
  year: 1998
  ident: e_1_3_2_3_2
  article-title: A critical role for IL-13 in resistance to intestinal nematode infection
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.160.7.3453
  contributor:
    fullname: Bancroft A. J.
– volume: 151
  start-page: 4266
  year: 1993
  ident: e_1_3_2_7_2
  article-title: Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.151.8.4266
  contributor:
    fullname: Eklund K. K.
– ident: e_1_3_2_41_2
  doi: 10.1084/jem.173.2.519
– ident: e_1_3_2_5_2
  doi: 10.1182/blood.V75.12.2271.2271
– volume: 79
  start-page: 146
  year: 1993
  ident: e_1_3_2_30_2
  article-title: Interleukin-9 potentiates the interleukin-4 induced IgE and IgG1 release from murine B lymphocytes
  publication-title: Immunology
  contributor:
    fullname: Petit-Frère C.
– ident: e_1_3_2_37_2
  doi: 10.1046/j.1365-3024.1996.d01-115.x
– volume: 150
  start-page: 3434
  year: 1993
  ident: e_1_3_2_39_2
  article-title: A primary intestinal helminthic infection rapidly induces a gut associated elevation of Th2-associated cytokines and IL-3
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.150.8.3434
  contributor:
    fullname: Svetic A.
– volume: 134
  start-page: 910
  year: 1985
  ident: e_1_3_2_33_2
  article-title: A cloned MCGF cDNA encodes a multilineage haematopoietic growth factor: multiple activities of interleukin-3
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.134.2.910
  contributor:
    fullname: Rennick D. M.
– ident: e_1_3_2_43_2
  doi: 10.1017/S0031182000072395
– volume: 153
  start-page: 3989
  year: 1994
  ident: e_1_3_2_35_2
  article-title: IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-β and IL-4 and is inhibited by IFN-γ
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.153.9.3989
  contributor:
    fullname: Schmitt E.
– ident: e_1_3_2_42_2
  doi: 10.1073/pnas.85.18.6934
– volume: 72
  start-page: 508
  year: 1991
  ident: e_1_3_2_8_2
  article-title: Cellular immune responses to the murine nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection
  publication-title: Immunology
  contributor:
    fullname: Else K. J.
– ident: e_1_3_2_6_2
  doi: 10.1002/eji.1830230743
– volume: 144
  start-page: 4235
  year: 1990
  ident: e_1_3_2_31_2
  article-title: Human P40/IL-9: expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.144.11.4235
  contributor:
    fullname: Renauld J.-C.
– ident: e_1_3_2_23_2
  doi: 10.1006/expr.1996.0090
– ident: e_1_3_2_38_2
  doi: 10.1016/0167-5699(93)90318-F
– ident: e_1_3_2_11_2
  doi: 10.1111/pim.1993.15.10.595
– ident: e_1_3_2_13_2
  doi: 10.1111/j.1365-3024.1992.tb00018.x
– ident: e_1_3_2_19_2
  doi: 10.4049/jimmunol.160.8.3989
– volume: 159
  start-page: 2616
  year: 1997
  ident: e_1_3_2_25_2
  article-title: IL-4-independent regulation of in vivo IL-9 expression
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.159.6.2616
  contributor:
    fullname: Monteyne P.
– volume: 74
  start-page: 329
  year: 1991
  ident: e_1_3_2_20_2
  article-title: Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes
  publication-title: Immunology
  contributor:
    fullname: Grencis R. K.
– volume: 151
  start-page: 1235
  year: 1993
  ident: e_1_3_2_15_2
  article-title: Anti-cytokine antibodies as carrier proteins: prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.151.3.1235
  contributor:
    fullname: Finkelman F. D.
– ident: e_1_3_2_2_2
  doi: 10.1038/383787a0
– ident: e_1_3_2_22_2
  doi: 10.1111/j.1365-3024.1990.tb00938.x
– volume: 62
  start-page: 629
  year: 1987
  ident: e_1_3_2_29_2
  article-title: Characterization and mast cell origin of a chymotrypsin-like proteinase isolated from intestines of mice infected with Trichinella spiralis
  publication-title: Immunology
  contributor:
    fullname: Newlands G. F. J.
SSID ssj0014448
Score 1.9797096
Snippet Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit...
Upon infection with the cecum-dwelling nematode Trichuris muris, the majority of inbred strains of mice launch a Th2-type immune response and in doing so expel...
ABSTRACT Upon infection with the cecum-dwelling nematode Trichuris muris , the majority of inbred strains of mice launch a Th2-type immune response and in...
Upon infection with the cecum-dwelling nematode Trichuris muris , the majority of inbred strains of mice launch a Th2-type immune response and in doing so...
SourceID pubmedcentral
proquest
crossref
pubmed
pascalfrancis
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 3832
SubjectTerms AIDS/HIV
Analysis of the immune response. Humoral and cellular immunity
Animals
Biological and medical sciences
Cell Line
Experimental helminthic diseases. Models
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Fungal and Parasitic Infections
Gene Expression
Helminthic diseases
Immunity, Innate - immunology
Immunobiology
Infectious diseases
Interleukin-9 - genetics
Interleukin-9 - immunology
Lymphokines, interleukins ( function, expression)
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Transgenic
Parasitic diseases
Regulatory factors and their cellular receptors
Th2 Cells - immunology
Trichuriasis - immunology
Trichuriasis - metabolism
Trichuris - immunology
Title Interleukin-9 Enhances Resistance to the Intestinal Nematode Trichuris muris
URI http://iai.asm.org/content/66/8/3832.abstract
https://www.ncbi.nlm.nih.gov/pubmed/9673269
https://search.proquest.com/docview/16492184
https://search.proquest.com/docview/80017637
https://pubmed.ncbi.nlm.nih.gov/PMC108429
Volume 66
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3BTtwwEB0VJCouVaFFDRTqQ6_OJrHXsY8IgQABqiqQuFmO42ijsl5Edg_9e8aJs-1W7aWXyFJsS_GzZ97E42eArzar0UmYijpZcMqtUlQ6x2gtpkYYoSpue7XPO3H5wK8fp4_xUFgX0yq9rdrUP81T38763MrnuZ2MeWKTb7dneSbRjE62YKtkbIzQ484B5zxaX0WR-5cxpwvN8OTq9CoVIpUpRmUFZRjahLN6chd2lCiRxqhN3zTqBYd0SdPhiDXDVRd_46J_plT-5qMu3sO7SC7J6fARe_DG-X3YGa6b_LkPb2_jRvoHuOn_BD651Y_WU0XO_Syg35HvrguEEstkuSBIDkmoiGYg9HsX9F0XtSP3aDxnQX2QzMPzIzxcnN-fXdJ4sQK1TGZLakWDvIsxY5D-1Eo6LLvGlLkqKwwRlatkzgQTU1ZxxXCZS-WYndpcItkqG8cOYNsvvPsEJGMMV3WUfS-MkEHnNseWvOBNmdcJZOOQ6udBP0P3cUchNeKhhdBSBzx0wEMHPBI4HIdem26uW9P-qpbA8QYY6057KTfOEvgygqNxoYTdD-PdYtVpjAtViGf_XUMGly1YmcDBAOa68zg_EhAbKK_fB43uzTc4dXut7mGqHv5vwyPYHQ5BhozDz7C9fFm5Y2RBy-qkn_av-EYCbA
link.rule.ids 230,315,733,786,790,891,27957,27958,53827,53829
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFH6CocEu_BhMZDCWA1enTew69nGaNrXQVgi10m6W4zhqtDWdSHqAv57nxCl0ggNcIkt2LMXf8_P34ufPAB_NMMdFQmfEioQRZqQkwlpKcj7SXHOZMdOqfc75eMk-3Yxu_KGw2qdVViYro-puHVXlqs2tvF-bQZ8nNvgyu4yHAt3o4DE8wemapH2M7vcOGGPe_0qC7D_1WV3oiAeTi0nEeSQijMsSQjG4caf1xBEcSp4ikZH7q1OvGOwSJnWNY1Z0l138iY0-TKr8bZW6fgHL_vu65JTbaNtkkfnxQPrxXwfgJTz3tDW86GpfwSNbHcNhd5Hl92N4OvNb9K9h2v5jvLPb27IiMryqVs6u6vCrrR1VxXLYbEKknaFriA7G9Tt3yrGb3IYLdMsrp2sYrt3zDSyvrxaXY-KvbCCGimFDDC-Q0VGqNRKrXAqLZVvoNJZphsGntJmIKad8RDMmKToQIS01IxMLpHFpYekJHFSbyr6FcEgp-gsvKJ9oLpyCboxvsoQVaZwHMOyhUvedModqI5pEKMRZca6Ecjgrh7NyOAdw2kOqdL1WpS5_NQvgbA_kXaetSByjAZz3oCucgm5fRVd2s60VRpzSRcp_byEcGeA0DeCkM5Jd597uAuB71rOrd-rf-zVoE60KeGcDp__74jk8Gy9mUzWdzD-_g6PuqKXLa3wPB823rT1DrtVkH9qp9RN1ISQr
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB1RKhAX2tKihpaSQ6_Ol72OfUSUFdvCClUg0ZPlOI42gs2umuyh_fWM87HtovbCJbIU21I84_F78fgZ4LOJclwkdEasSBhhRkoirKUk5yPNNZcZM63a55Rf3LKvd6O7LRDDWZg2ad9kZVA9zIOqnLW5lcu5CYc8sfD66iyOBIbRcJkX4Qt4iVM2kQNP7_cPGGN9DJYEGUDaZ3ZhMA4np5OA80AEyM0SQpHguBN7Yg92JE8RzMjNFWpQDXZJk7rGcSu6Cy_-hUifJlb-tVKNX8GP4Ru7BJX7YNVkgfn9RP7xOYPwGvZ7-OqfdjXewJatDmCnu9Dy1wHsXvVb9W_hsv3X-GBX92VFpH9ezZx_1f53WzvIimW_WfgIP31XEQON63fqFGQXufVvMDzPnL6hP3fPd3A7Pr85uyD91Q3EUBE1xPACkR2lWiPAyqWwWLaFTmOZZkhCpc1ETDnlI5oxSTGQCGmpGZlYIJxLC0sPYbtaVPY9-BGlGDd6YflEc-GUdGNsyRJWpHHuQTSYSy07hQ7VMptEKLS14lwJ5WytnK2Vs7UHR4NZla7nqtTln2oeHG8Yet1pKxbHqAcng-EVTkW3v6Iru1jVCpmndIz5_zWEAwWcph4cdo6y7rz3PQ_4hget3zsV8M036BetGnjnB0fPbXgCu9dfxupyMv32Afa6E5cuvfEjbDc_V_YYIVeTfWpn1yO34yar
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interleukin-9+Enhances+Resistance+to+the+Intestinal+Nematode+Trichuris+muris&rft.jtitle=Infection+and+immunity&rft.au=Faulkner%2C+Helen&rft.au=Renauld%2C+J.-C.&rft.au=Van+Snick%2C+J.&rft.au=Grencis%2C+R.+K.&rft.date=1998-08-01&rft.issn=0019-9567&rft.eissn=1098-5522&rft.volume=66&rft.issue=8&rft.spage=3832&rft.epage=3840&rft_id=info:doi/10.1128%2FIAI.66.8.3832-3840.1998&rft.externalDBID=n%2Fa&rft.externalDocID=10_1128_IAI_66_8_3832_3840_1998
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0019-9567&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0019-9567&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0019-9567&client=summon