Sanguinarine Attenuates Lipopolysaccharide-induced Inflammation and Apoptosis by Inhibiting the TLR4/NF-κB Pathway in H9c2 Cardiomyocytes

• Published in: Current medical science Vol. 38; no. 2; pp. 204 - 211
• Main Authors: Meng, Yan-yan, Liu, Yuan, Hu, Zhe-fu, Zhang, Yao, Ni, Jian, Ma, Zhen-guo, Liao, Hai-han, Wu, Qing-qing, Tang, Qi-zhu
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.04.2018; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, China; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Hubei Key Laboratory of Cardiology, Wuhan 430060, China
• Subjects: Medicine; Medicine & Public Health; sanguinarine; apoptosis; lipopolysaccharides; inflammation; H9c2 cardiac cells

Summary The inflammatory response is involved in the pathogenesis of the most common types of heart disease. Sanguinarine (SAN) has various pharmacological properties such as anti-inflammatory, antioxidant, antibacterial, antitumor, and immune-enhancing properties. However, few studies have investig...