MiR-21 Suppresses Anoikis through Targeting PDCD4 and PTEN in Human Esophageal Adenocarcinoma

• Published in: Current medical science Vol. 38; no. 2; pp. 245 - 251
• Main Authors: Zhao, Meng-ya, Wang, La-mei, Liu, Jing, Huang, Xing, Zhang, Ya-fei
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.04.2018; Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China%Department of Medical Ultrasound, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430060, China%Department of Emergency Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China%Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
• Subjects: Medicine; Medicine & Public Health; PDCD4; PTEN; miR-21; esophageal adenocarcinoma; anoikis resistance

Summary Anoikis is a form of apoptosis induced upon cell detachment from extracellular matrix. It has been determined that acquisition of resistance to anoikis is a critical step for tumor cell metastasis. MiR-21, the most prominent oncomiR, plays an important role in tumor progression. In this stud...