Protein metabolism in cirrhotic rats: effect of dietary restriction
This paper evaluates the role of decreased food intake in protein metabolism in cirrhotic animals by comparing the changes with those observed in pair-fed controls. Rats were injected with [14C]leucine and then divided into 3 groups. Liver cirrhosis was induced in 1 group of rats by repeated intraga...
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Published in | Annals of nutrition and metabolism Vol. 39; no. 6; p. 346 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
1995
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Abstract | This paper evaluates the role of decreased food intake in protein metabolism in cirrhotic animals by comparing the changes with those observed in pair-fed controls. Rats were injected with [14C]leucine and then divided into 3 groups. Liver cirrhosis was induced in 1 group of rats by repeated intragastric administration of CCl4 in oil over a period of 8 weeks. Control animals were gavaged with oil and either pair-fed or given access to food ad libitum. Three days after the last intragastric dose, rats were injected with [3H]leucine and sacrificed 20 min later. The daily food intake of CCl4 rats declined to 60% of that of the ad libitum controls. Both the pair-fed control group and the cirrhotic group showed decreased body weight gain, and a decline in muscle and intestinal protein degradation. The pair-fed and the cirrhotic groups differed from one another in many metabolic abnormalities. In the cirrhotic group we observed higher levels of serine, asparagine, proline, methionine, tyrosine, phenylalanine, ornithine and histidine, and lower levels of valine, isoleucine and arginine. In these animals higher relative (per kilogram body weight) weights and protein content of the spleen, kidneys and heart were observed. Additionally higher liver weight despite lower protein concentration, as well as lower liver protein degradation and lower skeletal muscle protein synthesis were found. |
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AbstractList | This paper evaluates the role of decreased food intake in protein metabolism in cirrhotic animals by comparing the changes with those observed in pair-fed controls. Rats were injected with [14C]leucine and then divided into 3 groups. Liver cirrhosis was induced in 1 group of rats by repeated intragastric administration of CCl4 in oil over a period of 8 weeks. Control animals were gavaged with oil and either pair-fed or given access to food ad libitum. Three days after the last intragastric dose, rats were injected with [3H]leucine and sacrificed 20 min later. The daily food intake of CCl4 rats declined to 60% of that of the ad libitum controls. Both the pair-fed control group and the cirrhotic group showed decreased body weight gain, and a decline in muscle and intestinal protein degradation. The pair-fed and the cirrhotic groups differed from one another in many metabolic abnormalities. In the cirrhotic group we observed higher levels of serine, asparagine, proline, methionine, tyrosine, phenylalanine, ornithine and histidine, and lower levels of valine, isoleucine and arginine. In these animals higher relative (per kilogram body weight) weights and protein content of the spleen, kidneys and heart were observed. Additionally higher liver weight despite lower protein concentration, as well as lower liver protein degradation and lower skeletal muscle protein synthesis were found. |
Author | Holecek, M Skopec, F Sprongl, L |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8678470$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1007_BF01318880 crossref_primary_10_1016_j_etp_2006_11_007 crossref_primary_10_1016_S0168_8278_97_80124_9 crossref_primary_10_1016_S0261_5614_99_80043_0 crossref_primary_10_1111_iep_12299 crossref_primary_10_1111_j_1365_2613_2012_00812_x crossref_primary_10_1111_iep_12322 crossref_primary_10_1016_j_nut_2014_03_016 crossref_primary_10_1177_014860719902300132 crossref_primary_10_1093_jn_131_3_813 crossref_primary_10_1002_cbf_1166 crossref_primary_10_1016_j_nut_2009_06_027 crossref_primary_10_1046_j_1365_2362_1999_00469_x crossref_primary_10_1016_j_cld_2011_12_009 |
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SubjectTerms | Amino Acids - blood Animals Body Weight Carbon Tetrachloride Food Deprivation Intestine, Small - metabolism Intestine, Small - pathology Kidney - metabolism Kidney - pathology Leucine - metabolism Liver - metabolism Liver - pathology Liver Cirrhosis, Experimental - chemically induced Liver Cirrhosis, Experimental - metabolism Male Myocardium - metabolism Myocardium - pathology Organ Size Proteins - metabolism Rats Rats, Wistar Spleen - metabolism Spleen - pathology |
Title | Protein metabolism in cirrhotic rats: effect of dietary restriction |
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