Oligodendrocyte maturation is inhibited by bone morphogenetic protein

• Published in: Molecular and cellular neuroscience Vol. 26; no. 4; pp. 481 - 492
• Main Authors: See, Jill, Zhang, Xianchao, Eraydin, Nuri, Mun, Sung-Bin, Mamontov, Polina, Golden, Jeffrey A, Grinspan, Judith B
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2004
• Subjects: 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism; Animals; Antigens, Differentiation - metabolism; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins - metabolism; Bone Morphogenetic Proteins - pharmacology; Cell Differentiation - drug effects; Cell Differentiation - physiology; Cells, Cultured; Central Nervous System - cytology; Central Nervous System - growth & development; Central Nervous System - metabolism; Down-Regulation - drug effects; Down-Regulation - physiology; Galactosylceramides - metabolism; Growth Inhibitors - metabolism; Growth Inhibitors - pharmacology; Myelin Basic Protein - drug effects; Myelin Basic Protein - metabolism; Myelin Proteolipid Protein - metabolism; Myelin-Associated Glycoprotein - metabolism; Nerve Fibers, Myelinated - metabolism; Nerve Fibers, Myelinated - ultrastructure; Oligodendroglia - cytology; Oligodendroglia - drug effects; Oligodendroglia - metabolism; Rats; Rats, Sprague-Dawley; Stem Cells - cytology; Stem Cells - drug effects; Stem Cells - metabolism

Mature oligodendrocytes myelinate axons in the CNS. The development of the myelin sheath is dependent on the proper maturation of oligodendrocytes from precursors cells, a spatially restricted process that is regulated by inductive and repressive cues. Several members of the bone morphogenetic prote...