Reynosin from Sassurea lappa as inhibitor on CINC-1 induction in LPS-stimulated NRK-52E cells

An inhibitor on CINC-1 (cytokine-induced neutrophil chemoattractant-1) induction in LPS-stimulated rat kidney epithelioid NRK-52E cells was purified from the roots of Sassurea lappa Clarke, a herbal medicine used in Korean traditional prescriptions for gastric intestinal diseases by a variety of col...

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Published inPlanta medica Vol. 64; no. 5; pp. 454 - 455
Main Authors Jung, J.H, Ha, J.Y, Min, K.R, Shibata, F, Nakagawa, H, Kang, S.S, Chang, I.M, Kim, Y
Format Journal Article
LanguageEnglish
Published Germany 01.06.1998
Subjects
Animals
Asteraceae
Cell Line
cell lines
chemical constituents of plants
Chemokine CXCL1
Chemokines, CXC - antagonists & inhibitors
Chemokines, CXC - biosynthesis
Chemotactic Factors - biosynthesis
cytokines
Growth Substances - biosynthesis
inflammation
inhibition
inhibitors
Intercellular Signaling Peptides and Proteins
leukocytes
Lipopolysaccharides - pharmacology
Magnetic Resonance Spectroscopy
Plants, Medicinal - chemistry
Rats
roots
Sesquiterpenes - pharmacology
sesquiterpenoid lactones
traditional medicine
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Summary:An inhibitor on CINC-1 (cytokine-induced neutrophil chemoattractant-1) induction in LPS-stimulated rat kidney epithelioid NRK-52E cells was purified from the roots of Sassurea lappa Clarke, a herbal medicine used in Korean traditional prescriptions for gastric intestinal diseases by a variety of column chromatographic procedures. The inhibitor was identified as reynosin, a sesquiterpene lactone isolated and characterized previously from Ambrosia confertiflora DC., and Magnolia grandiflora L. Reynosin exhibited a dose-dependent inhibition on CINC-1 induction in LPS-stimulated NRK-52E cells, where 50% of inhibitory effect was shown at the concentration of about 1 microM.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2006-957480