Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer

• Published in: Genetics and molecular research Vol. 14; no. 4; pp. 14979 - 14988
• Main Authors: Rodrigues, P R S, Maia, L L, Santos, M, Peterle, G T, Alves, L U, Takamori, J T, Souza, R P, Barbosa, W M, Mercante, A M C, Nunes, F D, Carvalho, M B, Tajara, E H, Louro, I D, Silva-Conforti, A M A
• Format: Journal Article
• Language: English
• Published: Brazil 01.01.2015
• Subjects: Adult; Aged; Alleles; Amino Acid Substitution; Biomarkers, Tumor - genetics; Blood-Brain Barrier; Body Mass Index; Female; Genotype; Humans; Leptin - genetics; Male; Middle Aged; Mouth Neoplasms - genetics; Oropharyngeal Neoplasms - genetics; Polymorphism, Genetic - genetics; Prognosis; Receptors, Leptin - genetics; Risk Factors

The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Ar...