The microenvironment following oxygen glucose deprivation/re-oxygenation-induced BSCB damage in vitro

• Published in: Brain research bulletin Vol. 143; pp. 171 - 180
• Main Authors: Cai, Xiao-Jun, Zhao, Jing-Jing, Lu, Yi, Zhang, Jian-Ping, Ren, Bing-Yan, Cao, Ting-Ting, Xi, Guang-Jun, Li, Zai-Wang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2018
• Subjects: Blood-spinal cord barrier; Oxygen glucose deprivation; Proinflammatory factors; Re-oxygenation; Tight junction proteins; Transepithelial electrical resistance; Blood-spinal cord barrier; Oxygen glucose deprivation; Transepithelial electrical resistance; Tight junction proteins; Proinflammatory factors; Re-oxygenation

•The inflammatory mediators were increased after BSCB damage induced by OGD/R.•Tight junction proteins deteriorate persistently after BSCB damage induced by OGD/R.•BSCB permeability increases longitudinally after BSCB damage induced by OGD/R.•BSCB secondary damage and inflammation injury after OGD/R...