Detection of brain tumors using fluorescence diffuse optical tomography and nanoparticles as contrast agents

• Published in: Journal of biomedical optics Vol. 17; no. 12; p. 126004
• Main Authors: Fortin, Pierre-Yves, Genevois, Coralie, Koenig, Anne, Heinrich, Emilie, Texier, Isabelle, Couillaud, Franck
• Format: Journal Article
• Language: English
• Published: United States 01.12.2012
• Subjects: Animals; Brain; Brain Neoplasms - pathology; Cell Line, Tumor; Contrast agents; Contrast Media - chemistry; Female; Fluorescence; Image Enhancement - methods; Imaging; Mice; Mice, Nude; Microscopy, Fluorescence - methods; Nanoparticles; Nanoparticles - chemistry; Position (location); Reproducibility of Results; Sensitivity and Specificity; Tomography, Optical - methods; Tumors

Near-infrared fluorescence-enhanced diffuse optical tomography (fDOT) is used to localize tumors in mice using fluorescent nanoparticles as a blood pool contrast agent. The infrared dye DiR is loaded in the lipid core of nontargeted nanoparticles (DiR-lipidots) and injected systemically via the tail...