Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers - Mori, Daiki; Kashihara, Yushi; Yoshikado, Takashi; Kimura, Miyuki; Hirota, Takeshi; Matsuki, Shunji; Maeda, Kazuya; Irie, Shin; Ieiri, Ichiro; Sugiyama, Yuichi; Kusuhara, Hiroyuki (Drug metabolism and pharmacokinetics, 2019)
Keywords: Adult; Biomarker; Coproporphyrin I; Endogenous substrate; Female; Gender difference; Genotype; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage; Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood; Liver-Specific Organic Anion Transporter 1 - blood; Liver-Specific Organic Anion Transporter 1 - genetics; Male; OATP1B1 genotype; Pharmaceutical Preparations - administration & dosage; Pharmaceutical Preparations - blood; Statin; Substrate Specificity - physiology; Young Adult; GCDCA-S; Endogenous substrate; Biomarker; CDCA-24G; Coproporphyrin I; Gender difference; DDI; OATP1B3; MRM; Statin; LC–MS/MS; OATP1B1; AUC; CV; CP-I; OCT2; MATE1; TLCA-S; OATP1B1 genotype; LCA-S; GLCA-S