Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid ω-hydroxylation

Genetic variations in cytochrome P450 4A11 (CYP4A11) contributes to inter-individual variability in the metabolism of fatty acids such as arachidonic acid. CYP4A11 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which is important for the regulation of blood pressure. Poly...

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Published inDrug metabolism and pharmacokinetics Vol. 30; no. 1; pp. 119 - 122
Main Authors Saito, Takahiro, Honda, Masashi, Takahashi, Masamitsu, Tsukada, Chiharu, Ito, Miyabi, Katono, Yuki, Hosono, Hiroki, Saigusa, Daisuke, Suzuki, Naoto, Tomioka, Yoshihisa, Hirasawa, Noriyasu, Hiratsuka, Masahiro
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2015
Subjects
20-HETE
Alleles
Animals
Arachidonic acid
Arachidonic Acid - metabolism
Cercopithecus aethiops
COS Cells
CYP4A11
Cytochrome P-450 CYP4A
Cytochrome P-450 Enzyme System - genetics
Cytochrome P-450 Enzyme System - metabolism
Cytochrome P450
Genetic polymorphisms
Genotype
Humans
Hydroxylation
Hypertension
Mutagenesis, Site-Directed
Polymorphism, Single Nucleotide
Transfection
Hypertension
20-HETE
Arachidonic acid
Cytochrome P450
Genetic polymorphisms
CYP4A11
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Abstract Genetic variations in cytochrome P450 4A11 (CYP4A11) contributes to inter-individual variability in the metabolism of fatty acids such as arachidonic acid. CYP4A11 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which is important for the regulation of blood pressure. Polymorphisms in CYP4A11 are associated with susceptibility to hypertension. In this study, we evaluated the in vitro ω-hydroxylation of arachidonic acid by 10 CYP4A11 allelic variants, which cause amino acid substitutions in the encoded proteins. CYP4A11 variants were heterologously expressed in COS-7 cells and the kinetic parameters of arachidonic acid ω-hydroxylation were estimated. Among 10 CYP4A11 variants, 5 (CYP4A11-v1, CYP4A11-v2, CYP4A11-v3, CYP4A11-v4, and CYP4A11-v7) showed no or markedly lower activity compared to wild-type CYP4A11. This functional analysis of CYP4A11 variants could provide useful information for the effective prevention and treatment of hypertension.
AbstractList Genetic variations in cytochrome P450 4A11 (CYP4A11) contributes to inter-individual variability in the metabolism of fatty acids such as arachidonic acid. CYP4A11 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which is important for the regulation of blood pressure. Polymorphisms in CYP4A11 are associated with susceptibility to hypertension. In this study, we evaluated the in vitro ω-hydroxylation of arachidonic acid by 10 CYP4A11 allelic variants, which cause amino acid substitutions in the encoded proteins. CYP4A11 variants were heterologously expressed in COS-7 cells and the kinetic parameters of arachidonic acid ω-hydroxylation were estimated. Among 10 CYP4A11 variants, 5 (CYP4A11-v1, CYP4A11-v2, CYP4A11-v3, CYP4A11-v4, and CYP4A11-v7) showed no or markedly lower activity compared to wild-type CYP4A11. This functional analysis of CYP4A11 variants could provide useful information for the effective prevention and treatment of hypertension.Genetic variations in cytochrome P450 4A11 (CYP4A11) contributes to inter-individual variability in the metabolism of fatty acids such as arachidonic acid. CYP4A11 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which is important for the regulation of blood pressure. Polymorphisms in CYP4A11 are associated with susceptibility to hypertension. In this study, we evaluated the in vitro ω-hydroxylation of arachidonic acid by 10 CYP4A11 allelic variants, which cause amino acid substitutions in the encoded proteins. CYP4A11 variants were heterologously expressed in COS-7 cells and the kinetic parameters of arachidonic acid ω-hydroxylation were estimated. Among 10 CYP4A11 variants, 5 (CYP4A11-v1, CYP4A11-v2, CYP4A11-v3, CYP4A11-v4, and CYP4A11-v7) showed no or markedly lower activity compared to wild-type CYP4A11. This functional analysis of CYP4A11 variants could provide useful information for the effective prevention and treatment of hypertension.
Genetic variations in cytochrome P450 4A11 (CYP4A11) contributes to inter-individual variability in the metabolism of fatty acids such as arachidonic acid. CYP4A11 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which is important for the regulation of blood pressure. Polymorphisms in CYP4A11 are associated with susceptibility to hypertension. In this study, we evaluated the in vitro ω-hydroxylation of arachidonic acid by 10 CYP4A11 allelic variants, which cause amino acid substitutions in the encoded proteins. CYP4A11 variants were heterologously expressed in COS-7 cells and the kinetic parameters of arachidonic acid ω-hydroxylation were estimated. Among 10 CYP4A11 variants, 5 (CYP4A11-v1, CYP4A11-v2, CYP4A11-v3, CYP4A11-v4, and CYP4A11-v7) showed no or markedly lower activity compared to wild-type CYP4A11. This functional analysis of CYP4A11 variants could provide useful information for the effective prevention and treatment of hypertension.
Genetic variations in cytochrome P450 4A11 (CYP4A11) contributes to inter-individual variability in the metabolism of fatty acids such as arachidonic acid. CYP4A11 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which is important for the regulation of blood pressure. Polymorphisms in CYP4A11 are associated with susceptibility to hypertension. In this study, we evaluated the in vitro ω-hydroxylation of arachidonic acid by 10 CYP4A11 allelic variants, which cause amino acid substitutions in the encoded proteins. CYP4A11 variants were heterologously expressed in COS-7 cells and the kinetic parameters of arachidonic acid ω-hydroxylation were estimated. Among 10 CYP4A11 variants, 5 (CYP4A11-v1, CYP4A11-v2, CYP4A11-v3, CYP4A11-v4, and CYP4A11-v7) showed no or markedly lower activity compared to wild-type CYP4A11. This functional analysis of CYP4A11 variants could provide useful information for the effective prevention and treatment of hypertension.
Author Tsukada, Chiharu
Hosono, Hiroki
Saito, Takahiro
Ito, Miyabi
Honda, Masashi
Takahashi, Masamitsu
Hiratsuka, Masahiro
Katono, Yuki
Suzuki, Naoto
Hirasawa, Noriyasu
Saigusa, Daisuke
Tomioka, Yoshihisa
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Cites_doi 10.1038/314620a0
10.1161/HYPERTENSIONAHA.108.114082
10.1016/j.gene.2012.10.007
10.1002/(SICI)1097-0134(19990215)34:3<403::AID-PROT12>3.0.CO;2-D
10.1016/S0022-3565(24)37530-5
10.1681/ASN.2008010063
10.1111/j.1601-5223.2012.02247.x
10.1016/j.gene.2011.07.015
10.1161/01.HYP.13.5_Suppl.I13
10.1038/10297
10.1161/01.RES.72.1.126
10.1161/01.HYP.0000182658.04299.15
10.1097/HJH.0b013e32834aa786
10.1161/01.CIR.0000151309.82473.59
10.1172/JCI119279
10.1177/1076029611436197
10.1097/HJH.0b013e3282f2f10c
10.1007/s11886-006-0098-7
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Issue 1
Keywords Hypertension
20-HETE
Arachidonic acid
Cytochrome P450
Genetic polymorphisms
CYP4A11
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References Barri (bib2) 2006; 8
Ma, Gebremedhin, Schwartzman, Falck, Clark, Masters (bib5) 1993; 72
Halushka, Fan, Bentley, Hsie, Shen, Weder (bib3) 1999; 22
Sugimoto, Akasaka, Katsuya, Node, Fujisawa, Shimaoka (bib8) 2008; 52
Williams, Hopkins, Jeunemaitre, Brown (bib15) 2011; 29
Nowicki, Chen, Aizman, Cheng, Li, Nowicki (bib7) 1997; 99
Fu, Yang, Ma, Huang, Xie, Zheng (bib10) 2013; 512
Fu, Ma, Xie, Huang, Yang, Nakayama (bib9) 2013; 19
Powell, Wolf, Jin, Lasker (bib16) 1998; 285
Chang, Loew (bib17) 1999; 34
Stokes, Kannel, Wolf, D'Agostino, Cupples (bib1) 1989; 13
Fu, Nakayama, Sato, Izumi, Kasamaki, Shindo (bib14) 2008; 26
Gainer, Lipkowitz, Yu, Waterman, Dawson, Capdevila (bib20) 2008; 19
Lino Cardenas, Renault, Farce, Cauffiez, Allorge, Lo-Guidice (bib18) 2011; 487
(bib19) 1993
Schwartzman, Ferreri, Carroll, Songu-Mize, McGiff (bib6) 1985; 314
Fu, Nakayama, Sato, Izumi, Kasamaki, Shindo (bib11) 2012; 149
Mayer, Lieb, Gotz, Konig, Aherrahrou, Thiemig (bib13) 2005; 46
Zou, Fleming, Falck, Jacobs, Gebremedhin, Harder (bib4) 1996; 270
Gainer, Bellamine, Dawson, Womble, Grant, Wang (bib12) 2005; 111
Ma (10.1016/j.dmpk.2014.09.001_bib5) 1993; 72
Zou (10.1016/j.dmpk.2014.09.001_bib4) 1996; 270
(10.1016/j.dmpk.2014.09.001_bib19) 1993
Gainer (10.1016/j.dmpk.2014.09.001_bib12) 2005; 111
Mayer (10.1016/j.dmpk.2014.09.001_bib13) 2005; 46
Sugimoto (10.1016/j.dmpk.2014.09.001_bib8) 2008; 52
Lino Cardenas (10.1016/j.dmpk.2014.09.001_bib18) 2011; 487
Fu (10.1016/j.dmpk.2014.09.001_bib11) 2012; 149
Williams (10.1016/j.dmpk.2014.09.001_bib15) 2011; 29
Powell (10.1016/j.dmpk.2014.09.001_bib16) 1998; 285
Schwartzman (10.1016/j.dmpk.2014.09.001_bib6) 1985; 314
Fu (10.1016/j.dmpk.2014.09.001_bib14) 2008; 26
Fu (10.1016/j.dmpk.2014.09.001_bib9) 2013; 19
Fu (10.1016/j.dmpk.2014.09.001_bib10) 2013; 512
Barri (10.1016/j.dmpk.2014.09.001_bib2) 2006; 8
Gainer (10.1016/j.dmpk.2014.09.001_bib20) 2008; 19
Stokes (10.1016/j.dmpk.2014.09.001_bib1) 1989; 13
Nowicki (10.1016/j.dmpk.2014.09.001_bib7) 1997; 99
Chang (10.1016/j.dmpk.2014.09.001_bib17) 1999; 34
Halushka (10.1016/j.dmpk.2014.09.001_bib3) 1999; 22
References_xml – volume: 22
  start-page: 239
  year: 1999
  end-page: 247
  ident: bib3
  article-title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
  publication-title: Nat Genet
– volume: 13
  start-page: I13
  year: 1989
  end-page: I18
  ident: bib1
  article-title: Blood pressure as a risk factor for cardiovascular disease. The Framingham Study–30 years of follow-up
  publication-title: Hypertension
– volume: 270
  start-page: R228
  year: 1996
  end-page: R237
  ident: bib4
  article-title: 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles
  publication-title: Am J Physiol
– volume: 512
  start-page: 510
  year: 2013
  end-page: 516
  ident: bib10
  article-title: Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China
  publication-title: Gene
– volume: 314
  start-page: 620
  year: 1985
  end-page: 622
  ident: bib6
  article-title: Renal cytochrome P450-related arachidonate metabolite inhibits (Na
  publication-title: Nature
– year: 1993
  ident: bib19
  publication-title: Cytochrome P-450
– volume: 29
  start-page: 1913
  year: 2011
  end-page: 1918
  ident: bib15
  article-title: CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow
  publication-title: J Hypertens
– volume: 487
  start-page: 10
  year: 2011
  end-page: 20
  ident: bib18
  article-title: Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population
  publication-title: Gene
– volume: 99
  start-page: 1224
  year: 1997
  end-page: 1230
  ident: bib7
  article-title: 20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na
  publication-title: J Clin Invest
– volume: 46
  start-page: 766
  year: 2005
  end-page: 771
  ident: bib13
  article-title: Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy
  publication-title: Hypertension
– volume: 34
  start-page: 403
  year: 1999
  end-page: 415
  ident: bib17
  article-title: Homology modeling and substrate binding study of human CYP4A11 enzyme
  publication-title: Proteins
– volume: 72
  start-page: 126
  year: 1993
  end-page: 136
  ident: bib5
  article-title: 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries
  publication-title: Circ Res
– volume: 285
  start-page: 1327
  year: 1998
  end-page: 1336
  ident: bib16
  article-title: Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11
  publication-title: J Pharmacol Exp Ther
– volume: 52
  start-page: 1142
  year: 2008
  end-page: 1148
  ident: bib8
  article-title: A polymorphism regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population
  publication-title: Hypertension
– volume: 8
  start-page: 411
  year: 2006
  end-page: 417
  ident: bib2
  article-title: Hypertension and kidney disease: a deadly connection
  publication-title: Curr Cardiol Rep
– volume: 149
  start-page: 91
  year: 2012
  end-page: 98
  ident: bib11
  article-title: Haplotype-based case-control study of CYP4A11 gene and myocardial infarction
  publication-title: Hereditas
– volume: 26
  start-page: 453
  year: 2008
  end-page: 461
  ident: bib14
  article-title: A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men
  publication-title: J Hypertens
– volume: 111
  start-page: 63
  year: 2005
  end-page: 69
  ident: bib12
  article-title: Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension
  publication-title: Circulation
– volume: 19
  start-page: 1606
  year: 2008
  end-page: 1612
  ident: bib20
  article-title: Association of a CYP4A11 variant and blood pressure in black men
  publication-title: J Am Soc Nephrol
– volume: 19
  start-page: 60
  year: 2013
  end-page: 65
  ident: bib9
  article-title: A novel polymorphism of the CYP4A11 gene is associated with coronary artery disease
  publication-title: Clin Appl Thromb Hemost
– volume: 314
  start-page: 620
  year: 1985
  ident: 10.1016/j.dmpk.2014.09.001_bib6
  article-title: Renal cytochrome P450-related arachidonate metabolite inhibits (Na+ + K+)ATPase
  publication-title: Nature
  doi: 10.1038/314620a0
– volume: 52
  start-page: 1142
  year: 2008
  ident: 10.1016/j.dmpk.2014.09.001_bib8
  article-title: A polymorphism regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.108.114082
– volume: 512
  start-page: 510
  year: 2013
  ident: 10.1016/j.dmpk.2014.09.001_bib10
  article-title: Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China
  publication-title: Gene
  doi: 10.1016/j.gene.2012.10.007
– volume: 270
  start-page: R228
  year: 1996
  ident: 10.1016/j.dmpk.2014.09.001_bib4
  article-title: 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles
  publication-title: Am J Physiol
– volume: 34
  start-page: 403
  year: 1999
  ident: 10.1016/j.dmpk.2014.09.001_bib17
  article-title: Homology modeling and substrate binding study of human CYP4A11 enzyme
  publication-title: Proteins
  doi: 10.1002/(SICI)1097-0134(19990215)34:3<403::AID-PROT12>3.0.CO;2-D
– volume: 285
  start-page: 1327
  year: 1998
  ident: 10.1016/j.dmpk.2014.09.001_bib16
  article-title: Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11
  publication-title: J Pharmacol Exp Ther
  doi: 10.1016/S0022-3565(24)37530-5
– volume: 19
  start-page: 1606
  year: 2008
  ident: 10.1016/j.dmpk.2014.09.001_bib20
  article-title: Association of a CYP4A11 variant and blood pressure in black men
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2008010063
– volume: 149
  start-page: 91
  year: 2012
  ident: 10.1016/j.dmpk.2014.09.001_bib11
  article-title: Haplotype-based case-control study of CYP4A11 gene and myocardial infarction
  publication-title: Hereditas
  doi: 10.1111/j.1601-5223.2012.02247.x
– volume: 487
  start-page: 10
  year: 2011
  ident: 10.1016/j.dmpk.2014.09.001_bib18
  article-title: Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population
  publication-title: Gene
  doi: 10.1016/j.gene.2011.07.015
– volume: 13
  start-page: I13
  year: 1989
  ident: 10.1016/j.dmpk.2014.09.001_bib1
  article-title: Blood pressure as a risk factor for cardiovascular disease. The Framingham Study–30 years of follow-up
  publication-title: Hypertension
  doi: 10.1161/01.HYP.13.5_Suppl.I13
– volume: 22
  start-page: 239
  year: 1999
  ident: 10.1016/j.dmpk.2014.09.001_bib3
  article-title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
  publication-title: Nat Genet
  doi: 10.1038/10297
– volume: 72
  start-page: 126
  year: 1993
  ident: 10.1016/j.dmpk.2014.09.001_bib5
  article-title: 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries
  publication-title: Circ Res
  doi: 10.1161/01.RES.72.1.126
– volume: 46
  start-page: 766
  year: 2005
  ident: 10.1016/j.dmpk.2014.09.001_bib13
  article-title: Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000182658.04299.15
– volume: 29
  start-page: 1913
  year: 2011
  ident: 10.1016/j.dmpk.2014.09.001_bib15
  article-title: CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow
  publication-title: J Hypertens
  doi: 10.1097/HJH.0b013e32834aa786
– volume: 111
  start-page: 63
  year: 2005
  ident: 10.1016/j.dmpk.2014.09.001_bib12
  article-title: Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000151309.82473.59
– year: 1993
  ident: 10.1016/j.dmpk.2014.09.001_bib19
– volume: 99
  start-page: 1224
  year: 1997
  ident: 10.1016/j.dmpk.2014.09.001_bib7
  article-title: 20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase
  publication-title: J Clin Invest
  doi: 10.1172/JCI119279
– volume: 19
  start-page: 60
  year: 2013
  ident: 10.1016/j.dmpk.2014.09.001_bib9
  article-title: A novel polymorphism of the CYP4A11 gene is associated with coronary artery disease
  publication-title: Clin Appl Thromb Hemost
  doi: 10.1177/1076029611436197
– volume: 26
  start-page: 453
  year: 2008
  ident: 10.1016/j.dmpk.2014.09.001_bib14
  article-title: A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men
  publication-title: J Hypertens
  doi: 10.1097/HJH.0b013e3282f2f10c
– volume: 8
  start-page: 411
  year: 2006
  ident: 10.1016/j.dmpk.2014.09.001_bib2
  article-title: Hypertension and kidney disease: a deadly connection
  publication-title: Curr Cardiol Rep
  doi: 10.1007/s11886-006-0098-7
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Snippet Genetic variations in cytochrome P450 4A11 (CYP4A11) contributes to inter-individual variability in the metabolism of fatty acids such as arachidonic acid....
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SubjectTerms 20-HETE
Alleles
Animals
Arachidonic acid
Arachidonic Acid - metabolism
Cercopithecus aethiops
COS Cells
CYP4A11
Cytochrome P-450 CYP4A
Cytochrome P-450 Enzyme System - genetics
Cytochrome P-450 Enzyme System - metabolism
Cytochrome P450
Genetic polymorphisms
Genotype
Humans
Hydroxylation
Hypertension
Mutagenesis, Site-Directed
Polymorphism, Single Nucleotide
Transfection
Title Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid ω-hydroxylation
URI https://dx.doi.org/10.1016/j.dmpk.2014.09.001
https://www.ncbi.nlm.nih.gov/pubmed/25760539
https://www.proquest.com/docview/1663656499
Volume 30
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