Expression of TET and 5-HmC in Trophoblast Villi of Women with Normal Pregnancy and with Early Pregnancy Loss

• Published in: Current medical science Vol. 38; no. 3; pp. 505 - 512
• Main Authors: Wu, Ai-hua, Yang, Dong-yu, Liu, Yu-dong, Chen, Xin, Chen, Xu-long, Lu, Shan, Chen, Shi-ling
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.06.2018; Center for Reproductive Medicine, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China%Center for Reproductive Medicine, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China%Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
• Subjects: Medicine; Medicine & Public Health; early pregnancy loss; 5-methylcytosine; ten-eleven translocation; villus; 5-hydroxymethylcytosine

Summary Increasing evidence suggests that epigenetic dysfunction may influence the stability of normal pregnancy. The ten-eleven translocation (TET) family and 5-hydroxymethylcytosine (5-hmC) were found to be linked with epigenetic reprogramming. The present study aimed to examine the expression of...