Intermittent-Excessive and Chronic-Moderate Ethanol Intake during Adolescence Impair Spatial Learning, Memory and Cognitive Flexibility in the Adulthood

• Published in: Neuroscience Vol. 418; pp. 205 - 217
• Main Authors: Contreras, Ana, Polín, Eduardo, Miguéns, Miguel, Pérez-García, Carmen, Pérez, Vicente, Ruiz-Gayo, Mariano, Morales, Lidia, Del Olmo, Nuria
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 15.10.2019
• Subjects: adolescence; binge drinking; GSK3β; hippocampus; long-term depression; memory; C; memory; hippocampus; fEPSPs; long-term depression; PND; EtOH; LTP; CM; i.p; binge drinking; AMPAR; GSK3β; ANOVA; BW; adolescence; NMDAR; KRB; IE; LTD; RAM

Intermittent and excessive ethanol consumption over very short periods of time, known as binge drinking, is common in the adolescence, considered a vulnerable period to the effects of alcohol in terms of cognitive performance. One of the brain functions most drastically affected by ethanol in adoles...