Chikungunya Infection in Solid Organ Transplant Recipients

• Published in: Transplantation proceedings Vol. 49; no. 9; pp. 2076 - 2081
• Main Authors: Girão, E.S., Rodrigues dos Santos, B.G., do Amaral, E.S., Costa, P.E.G., Pereira, K.B., de Araujo Filho, A.H., Hyppolito, E.B., Mota, M.U., Marques, L.C.B.F., Costa de Oliveira, C.M., da Silva, S.L., Garcia, J.H.P., Fernandes, P.F.C.B.C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2017
• Subjects: Adult; Arthralgia - etiology; Brazil; Chikungunya Fever - complications; Chikungunya Fever - diagnosis; Chikungunya virus - isolation & purification; Diagnosis, Differential; Endemic Diseases; Enzyme-Linked Immunosorbent Assay; Female; Fever - etiology; Humans; Immunoglobulin M - blood; Male; Middle Aged; Retrospective Studies; Transplant Recipients; Travel
• DOI: 10.1016/j.transproceed.2017.07.004
• ISSN: 0041-1345

Chikungunya virus (CHIKV) is an emerging mosquito-borne disease that causes acute febrile polyarthralgia and arthritis. CHIKV has spread rapidly to the Americas and, in Brazil, autochthonous cases are increasingly been reported. Solid organ transplant (SOT) recipients who travel to or live in CHIKV endemic areas are under high risk of acquiring the disease. Few data exist regarding the clinical characteristics of CHIKV infections in this population. We report the first case series of CHIKV infection in SOT recipients. We retrospectively evaluated 13 cases of CHIKV infection in SOT recipients between January 2016 and December 2016 confirmed by laboratory tests and transplanted in the Renal and Liver Transplant Units of Walter Cantídio University Hospital from Federal University of Ceará. Positive CHIKV serology (enzyme-linked immunosorbent assay immunoglobulin M) was found in all patients (9 kidney and 4 liver transplant recipients). All of these patients had been living in endemic areas for dengue and CHIKV in the past months before the illness. The mean time between transplantation and CHIKV infection was of 7.2 years. Fever presented in 11 (84.6%) patients and 5 (38.5%) presented with a maculopapular rash. All cases had joint symptoms: 11 (84.6%) with symmetrical and peripheral polyarthralgia/polyarthritis and 2 (15.3%) with monoarthralgia/monoarthritis. Six (46%) patients had a joint complaint that lasted 3 months. Two patients had concomitant positive dengue serology (enzyme-linked immunosorbent assay immunoglobulin M). There were no cases of complications or deaths. SOT with CHIKV infection seems to have a clinical presentation and evolution similar to those seen in the general population, with no apparent damage to the graft. •Chikungunya infections in solid organ transplant recipients are described.•This is a case series of nine kidney and four liver transplant recipients.•Fever was observed in 11 (84.6%) patients.•Five (38.5%) patients presented with a rash.•Thirteen SOT recipients with confirmed CHIKV infection were included in our study (nine kidney and four liver transplant recipients).•All cases presented with arthralgia.•Forty-six percent developed chronic joint complaints.