High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells

• Published in: The journal of clinical endocrinology and metabolism Vol. 85; no. 1; pp. 263 - 269
• Main Authors: PAEZ PEREDA, M, LEDDA, M. F, STALLA, G. K, GOLDBERG, V, CHERVIN, A, CARRIZO, G, MOLINA, H, MÜLLER, A, RENNER, U, PODHAJCER, O, ARZT, E
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 2000
• Subjects: Adenoma - metabolism; Adenoma - pathology; Adult; Aged; Aged, 80 and over; Animals; Biological and medical sciences; Blotting, Northern; Cell Division - drug effects; Cell Division - physiology; Endocrinopathies; Female; Humans; Hypothalamus. Hypophysis. Epiphysis (diseases); Male; Matrix Metalloproteinase 2 - biosynthesis; Matrix Metalloproteinase 9 - biosynthesis; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases - metabolism; Medical sciences; Middle Aged; Neoplastic Stem Cells; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Phenylalanine - analogs & derivatives; Phenylalanine - pharmacology; Pituitary Gland - cytology; Pituitary Gland - drug effects; Pituitary Gland - metabolism; Pituitary Hormones - biosynthesis; Pituitary Neoplasms - metabolism; Pituitary Neoplasms - pathology; Protease Inhibitors - pharmacology; Rats; Thiophenes - pharmacology; Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors; Tissue Inhibitor of Metalloproteinase-1 - metabolism; Tissue Inhibitor of Metalloproteinase-2 - antagonists & inhibitors; Tissue Inhibitor of Metalloproteinase-2 - metabolism; Tropical medicine; Tumor Cells, Cultured; South America; Argentina; America; Endocrinopathy; Human; Cell proliferation; Enzyme; Enzyme inhibitor; Metalloendopeptidases; Adenoma; In vitro; Biological activity; Gelatinase B; Gelatinase A; Endocrine secretion; Peptidases; Enzymatic activity; Pituitary diseases; Hydrolases; Pituitary gland; Benign neoplasm; Comparative study

Beside the digestion of the extracellular matrix during tumor invasion and metastasis, more recently, new functions for matrix metalloproteinases (MMPs) have been proposed. We studied the expression and function of these enzymes in pituitary cells. We observed the activities of MMP-2 and MMP-9 toget...